INT170260

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Context Info
Confidence 0.21
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.67
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
endothelial cells 2
platelets 2
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 79.48 Quite High
Inflammatory response 1 76.64 Quite High
Percutaneous transluminal coronary angioplasty 27 65.00 Quite High
Inflammation 1 16.40 Low Low
imagery 11 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 23 99.80 Very High Very High Very High
Adhesions 30 98.44 Very High Very High Very High
Brain Hemorrhage 64 98.00 Very High Very High Very High
Stress 1 93.68 High High
Arrhythmias 2 Under Development 66 90.72 High High
Injury 1 80.08 Quite High
Cv Unclassified Under Development 2 79.48 Quite High
Reperfusion Injury 1 78.36 Quite High
INFLAMMATION 2 76.28 Quite High
Atherosclerosis 3 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As expected, the median values of CD62P expression and PAC-1 binding in patients were significantly lower than in controls only in high responders (p < 0.0001) and intermediate responders (p < 0.0001 and p < 0.02, respectively).


Regulation (values) of Gene_expression (expression) of CD62P associated with heart rate under development
1) Confidence 0.21 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.38 Pain Relevance 0
Moreover, previous studies reported that an irregular heart rate blunted nitric oxide (NO) synthesis and increased p-selectin expression on platelets, ultimately increasing the risk for SBI [32,33].
Regulation (blunted) of Gene_expression (expression) of p-selectin in platelets associated with brain hemorrhage
2) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.44 Pain Relevance 0
The first contact between leukocytes and the vessel wall is established by members of the selectin family of adhesion molecules: L-selectin (CD62L), which is exclusively expressed by leukocytes; P-selectin (CD62P), which can be found in platelets and Weibel-Palade bodies of endothelial cells; and E-selectin (CD62E), a transcriptionally regulated glycoprotein exclusively expressed by endothelial cells.
Regulation (regulated) of Gene_expression (expressed) of P-selectin in endothelial cells associated with adhesions
3) Confidence 0.03 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.85 Pain Relevance 0.11

General Comments

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