INT170260

Context Info Confidence 0.21 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.67 Pain Relevance 0.11

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP) plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)

Anatomy Link Frequency endothelial cells 2 platelets 2 SELP (Homo sapiens)

Pain Link Frequency Relevance Heat ischemia 4 79.48 Inflammatory response 1 76.64 Percutaneous transluminal coronary angioplasty 27 65.00 Inflammation 1 16.40 imagery 11 5.00 cva 7 5.00 aspirin 5 5.00 Angina 4 5.00 adenocard 2 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Heart Rate Under Development 23 99.80 Adhesions 30 98.44 Brain Hemorrhage 64 98.00 Stress 1 93.68 Arrhythmias 2 Under Development 66 90.72 Injury 1 80.08 Cv Unclassified Under Development 2 79.48 Reperfusion Injury 1 78.36 INFLAMMATION 2 76.28 Atherosclerosis 3 72.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As expected, the median values of CD62P expression and PAC-1 binding in patients were significantly lower than in controls only in high responders (p < 0.0001) and intermediate responders (p < 0.0001 and p < 0.02, respectively).

Regulation (values) of Gene_expression (expression) of CD62P associated with heart rate under development

1) Confidence 0.21 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.38 Pain Relevance 0

Moreover, previous studies reported that an irregular heart rate blunted nitric oxide (NO) synthesis and increased p-selectin expression on platelets, ultimately increasing the risk for SBI [32,33].

Regulation (blunted) of Gene_expression (expression) of p-selectin in platelets associated with brain hemorrhage

2) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.44 Pain Relevance 0

The first contact between leukocytes and the vessel wall is established by members of the selectin family of adhesion molecules: L-selectin (CD62L), which is exclusively expressed by leukocytes; P-selectin (CD62P), which can be found in platelets and Weibel-Palade bodies of endothelial cells; and E-selectin (CD62E), a transcriptionally regulated glycoprotein exclusively expressed by endothelial cells.

Regulation (regulated) of Gene_expression (expressed) of P-selectin in endothelial cells associated with adhesions

3) Confidence 0.03 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.85 Pain Relevance 0.11

General Comments

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