INT17028

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Context Info
Confidence 0.41
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 9.83
Pain Relevance 7.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
muscles 4
plasma 1
margin 1
muscle fibers 1
muscle cells 1
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 360 99.78 Very High Very High Very High
nav1.3 1 99.68 Very High Very High Very High
ASIC 1 99.66 Very High Very High Very High
Spinal nerve ligature 1 99.30 Very High Very High Very High
Action potential 397 99.16 Very High Very High Very High
dorsal root ganglion 5 98.74 Very High Very High Very High
imagery 86 98.60 Very High Very High Very High
sodium channel 60 98.52 Very High Very High Very High
cocaine 2 97.74 Very High Very High Very High
local anesthetic 2 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 3 99.52 Very High Very High Very High
Injury 20 99.48 Very High Very High Very High
Death 370 99.44 Very High Very High Very High
Apoptosis 677 98.90 Very High Very High Very High
Ganglion Cysts 5 98.74 Very High Very High Very High
Pressure And Volume Under Development 82 98.72 Very High Very High Very High
Muscular Dystrophy 102 97.92 Very High Very High Very High
Neuropathic Pain 6 97.16 Very High Very High Very High
Rheumatoid Arthritis 6 96.92 Very High Very High Very High
INFLAMMATION 13 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pyrethroids chemically activate the silent Na+ channel in a manner similar to that with veratridine, batrachotoxin, or polypeptide toxins, which are known to slow down the inactivation process of a functional Na+ channel.
Positive_regulation (activate) of Na
1) Confidence 0.41 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6250606 Disease Relevance 0 Pain Relevance 0.22
Ouabain significantly increased the levels of Na+ in the tissue, while veratridine alone did not.
Positive_regulation (increased) of Na
2) Confidence 0.40 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1869029 Disease Relevance 0 Pain Relevance 0.10
ACh (100 microM) increased Na+i by approximately 80%.
Positive_regulation (increased) of Na
3) Confidence 0.40 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8380774 Disease Relevance 0 Pain Relevance 0.08
The potency of the local anesthetic drugs cocaine and tetracaine in inhibiting [14C]guanidinium ion influx depended upon the concentration of veratridine used to activate the Na+ channels.
Positive_regulation (activate) of Na associated with cocaine, local anesthetic and potency
4) Confidence 0.40 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2155120 Disease Relevance 0 Pain Relevance 0.49
The results indicate that glucose can induce oscillations of [Na+]i in pancreatic beta-cells, although this effect is usually less obvious due to activation of an efficient Na/K pump.
Positive_regulation (activation) of Na
5) Confidence 0.38 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8831697 Disease Relevance 0 Pain Relevance 0.13
Fluorescent imaging using the Na(+)-selective dye SBFI confirmed that TTX attenuated the increase in intracellular free Na+ induced by oxygen-glucose deprivation.
Positive_regulation (increase) of Na associated with tetrodotoxin and imagery
6) Confidence 0.28 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7714811 Disease Relevance 0.69 Pain Relevance 0.77
Analysis of mRNA of the TTXs subtypes of sodium channels in the DRG after spinal nerve ligation showed that Nav1.3 (Type III) and Nax (NaG) are the only two subtypes that are up-regulated, suggesting their potentially important role in ectopic discharge and neuropathic pain generation.
Positive_regulation (up-regulated) of Nax in DRG associated with nav1.3, dorsal root ganglion, spinal nerve ligature, neuropathic pain and sodium channel
7) Confidence 0.17 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469042 Disease Relevance 0.97 Pain Relevance 1.60
Additionally, an increase in Na+/K+ ATPase activity has been reported in mdx mice, suggesting an impairment in Na+ regulation (Dunn et al., 1995).
Positive_regulation (increase) of Na
8) Confidence 0.07 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.18 Pain Relevance 0.06
While increased Na+ entry in stimulated mdx muscle, in association with up-regulated activity of stretch-activated channels has been known (Yeung et al., 2003; Allen, 2004), the alteration of Nav1.4 gating properties reported in this paper appears to be important for both basal and stimulated Na+ entry and likely plays no less important a role in causing excessive Na+ entry in mdx muscle fibers.
Positive_regulation (increased) of Na in muscle
9) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.32
We observed that Na+ entry in dystrophic fibers, as assessed by 22Na+ uptake, was increased by 20% over that of control fibers.
Positive_regulation (increased) of Na
10) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.32
These observations of longer open dwell times and greater basal activity of Nav1.4s produce a good ground for explaining the observed approximately twofold increase in [Na+] under the sarcolemma of mdx5cv fibers.
Positive_regulation (increase) of Na
11) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
It is suggested that activation of voltage-dependent Na+ channels is a useful approach for amplifying Ca2+ signals for insulin release.
Positive_regulation (activation) of Na
12) Confidence 0.05 Published 1999 Journal Cell. Signal. Section Abstract Doc Link 10376807 Disease Relevance 0 Pain Relevance 0.16
RATIONALE: Acid-sensing ion channels (ASICs) are Na+ channels that are activated by acidic pH.
Positive_regulation (activated) of Na associated with asic
13) Confidence 0.05 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19590043 Disease Relevance 0 Pain Relevance 0.09
For example, Lopez-Santiago et al. (2007) associated a deletion of the Scn1b gene in a murine system with an increase in peak Na+ currents and QT prolongation.
Positive_regulation (increase) of Na
14) Confidence 0.05 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.12 Pain Relevance 0
TTX treatment restored Na+ influx into mdx5cv fibers to a level indistinguishable from that of C57BL/6J muscles, suggesting that Nav1.4 channels play an important role in regulating [Na+] under the sarcolemma of mdx muscles.


Positive_regulation (restored) of Na in muscles associated with tetrodotoxin
15) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.28
Thus, Nav1.4 channels are underexpressed, rather than overexpressed, in mdx fibers, highlighting the importance of a proper explanation of the increased Na+ entry.


Positive_regulation (increased) of Na
16) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.11
Moreover, veratridine, a stimulator of VGSC activity, induced Na+ overload, leading to increased cell death (Koike et al., 2000).
Positive_regulation (induced) of Na associated with death
17) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.55 Pain Relevance 0.38
One possible explanation for the increase in Na+ influx is that it is caused by overexpression of Nav1.4 in mdx muscles.
Positive_regulation (increase) of Na in muscles
18) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.51 Pain Relevance 0.30
TTX treatment restored Na+ influx into mdx5cv fibers to a level indistinguishable from that of C57BL/6J muscles, suggesting that Nav1.4 channels play an important role in regulating [Na+] under the sarcolemma of mdx muscles.


Positive_regulation (regulating) of Na in muscles associated with tetrodotoxin
19) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.27
The observation of an altered distribution pattern of Nav1.4 channels in mdx5cv fibers, which in itself involves important considerations, cannot fully explain the increase in Na+ influx in view of the smaller amount of the protein in sarcolemma.
Positive_regulation (increase) of Na
20) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0

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