INT17029

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 23
Total Number 26
Disease Relevance 3.89
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
peripheral nerve 3
diaphragm 1
spike 1
muscle 1
brain 1
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 422 100.00 Very High Very High Very High
noradrenaline 16 100.00 Very High Very High Very High
Dopamine 21 99.84 Very High Very High Very High
Neurotransmitter 5 99.40 Very High Very High Very High
opioid receptor 5 99.30 Very High Very High Very High
Delta opioid receptors 30 99.28 Very High Very High Very High
medulla 6 99.14 Very High Very High Very High
anticonvulsant 3 98.40 Very High Very High Very High
imagery 18 97.36 Very High Very High Very High
MU agonist 2 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 25 99.92 Very High Very High Very High
Injury 14 96.60 Very High Very High Very High
Death 96 96.32 Very High Very High Very High
Muscular Dystrophy 24 94.16 High High
Stress 16 90.84 High High
Targeted Disruption 93 86.72 High High
Ganglion Cysts 32 75.00 Quite High
Rupture 2 64.88 Quite High
Heart Arrhythmia 18 62.20 Quite High
Chronic Disease 4 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional expression of I(NaN) declined with time after cell dissociation and recovered during culture, implying that Na(v)1.9 may be regulated dynamically by trophic factors or depend on subtle environmental factors for its survival.
Regulation (regulated) of Na
1) Confidence 0.45 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 15290301 Disease Relevance 0.21 Pain Relevance 0.22
The effects on oxygen consumption of agents that modify Na(+)-permeability were examined in mouse diaphragm muscle perfused with a bathing solution that contained (+)-tubocurarine in a flow-through mode.
Regulation (modify) of Na in diaphragm
2) Confidence 0.24 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1869029 Disease Relevance 0 Pain Relevance 0
delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation.
Regulation (regulation) of Na associated with opioid receptor
3) Confidence 0.19 Published 2009 Journal Cell. Mol. Life Sci. Section Title Doc Link 19756387 Disease Relevance 0.60 Pain Relevance 0.41
Furthermore, we co-expressed DOR and Na+ channels in Xenopus oocytes and showed that DOR expression and activation indeed play an inhibitory role in Na+ channel regulation by decreasing the amplitude of sodium currents and increasing activation threshold of Na+ channels.
Regulation (regulation) of Na in oocytes associated with delta opioid receptors
4) Confidence 0.19 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19756387 Disease Relevance 0.55 Pain Relevance 0.44
Our results suggest that DOR protects from anoxic disruption of Na+ homeostasis via Na+ channel regulation.
Regulation (regulation) of Na associated with delta opioid receptors
5) Confidence 0.14 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19756387 Disease Relevance 0.55 Pain Relevance 0.46
Our results suggest that DOR protects from anoxic disruption of Na+ homeostasis via Na+ channel regulation.
Regulation (regulation) of Na associated with delta opioid receptors
6) Confidence 0.14 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19756387 Disease Relevance 0.55 Pain Relevance 0.46
delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation.
Regulation (regulation) of Na associated with opioid receptor
7) Confidence 0.14 Published 2009 Journal Cell. Mol. Life Sci. Section Title Doc Link 19756387 Disease Relevance 0.60 Pain Relevance 0.41
It has been suggested that ATPase might be the enzyme responsible for the observed pharmacological responses of the neurons to the application of the drug by affecting the Na+, K+ flux and neurotransmitter release.
Regulation (affecting) of Na in neurons associated with neurotransmitter
8) Confidence 0.07 Published 1985 Journal J Hirnforsch Section Abstract Doc Link 3005393 Disease Relevance 0 Pain Relevance 0.84
Developmental regulation of Na+ and K+ conductances in glial cells of mouse hippocampal brain slices.
Regulation (regulation) of Na in glial cells
9) Confidence 0.07 Published 1995 Journal Glia Section Title Doc Link 8567069 Disease Relevance 0 Pain Relevance 0.06
In the lower brainstem studied as a whole, the dipeptide did not affect the utilization of either NA or DA.
Neg (not) Regulation (affect) of NA in brainstem associated with medulla, dopamine and noradrenaline
10) Confidence 0.07 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6835989 Disease Relevance 0 Pain Relevance 1.05
Analysis of the data on the NA utilization in specific brain nuclei, however, revealed that the dipeptide affected NA disappearance in some mesencephalic-limbic nuclei which receive noradrenergic innervation from the dorsal noradrenergic bundle (e.g., nucl. raphe dorsalis, area tegmentalis ventralis, gyrus dentatus).
Regulation (affected) of NA in brain associated with noradrenaline and raphe
11) Confidence 0.07 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6835989 Disease Relevance 0 Pain Relevance 1.06
Effect of loperamide on Na+/D-glucose cotransporter activity in mouse small intestine.
Regulation (Effect) of Na in small intestine
12) Confidence 0.05 Published 2000 Journal J. Pharm. Pharmacol. Section Title Doc Link 10875545 Disease Relevance 0 Pain Relevance 0.10
Loperamide inhibited intestinal Na+, K+-ATPase activity, whilst sucrase activity was unaffected.
Neg (unaffected) Regulation (unaffected) of Na
13) Confidence 0.05 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10875545 Disease Relevance 0 Pain Relevance 0.06
The values of peak Na+ conductance (gNa) values were determined from the equationgNa=INa/(Vm?
Regulation (values) of Na
14) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0 Pain Relevance 0.04
The present findings complement reports of altered Na+ channel biophysical properties resulting from ?
Regulation (altered) of Na
15) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.12 Pain Relevance 0
Additionally, an increase in Na+/K+ ATPase activity has been reported in mdx mice, suggesting an impairment in Na+ regulation (Dunn et al., 1995).
Regulation (regulation) of Na
16) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.17 Pain Relevance 0.07
Thus, it can be argued that changes in Nav1.4 gating properties significantly affect the Na+ balance in FBD muscle fibers, producing an important long-term effect even in nonexercised muscle.
Regulation (affect) of Na in muscle
17) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.11 Pain Relevance 0
To further investigate the distribution of VGSCs, and to test whether the absence of dystrophin influences Na+ channel gating properties via syntrophin, we performed confocal imaging of mdx5cv and control fibers labeled with an anti-SkM1 monoclonal antibody against Nav1.4, and a polyclonal antiserum against ?
Spec (whether) Regulation (influences) of Na associated with imagery
18) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.08
To assess how these changes in Nav1.4 gating properties influence [Na+] under the sarcolemma, we measured the reversal potential for Na+.
Regulation (influence) of Na
19) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.04
On the other hand, activation of PKC has regulatory effects on skeletal muscle Na+ channels [25], brain Na+ channels [26] and peripheral nerve Na+ channel expressed in Xenopus oocytes [27].
Regulation (effects) of Na in peripheral nerve
20) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.06

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