INT170294

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.25
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
chondrocytes 2
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 100.00 Very High Very High Very High
metalloproteinase 37 100.00 Very High Very High Very High
ischemia 21 98.96 Very High Very High Very High
Inflammation 62 87.64 High High
Arthritis 39 83.56 Quite High
fibrosis 3 59.96 Quite High
antagonist 7 58.40 Quite High
Pain 5 57.12 Quite High
cytokine 18 37.00 Quite Low
cva 3 23.12 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 109 100.00 Very High Very High Very High
Keloid Scars 50 99.90 Very High Very High Very High
Cv General 4 Under Development 5 99.32 Very High Very High Very High
Injury 20 99.30 Very High Very High Very High
Adhesions 36 98.32 Very High Very High Very High
Disease 24 97.68 Very High Very High Very High
Severe Combined Immunodeficiency 20 97.20 Very High Very High Very High
Burns 5 97.04 Very High Very High Very High
Cicatrix 14 96.64 Very High Very High Very High
Brain Injury 4 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies, however, have shown that multiple tetracyclines can inhibit collagenase MMPs via down-regulation of gene expression in a cellular model of rheumatoid arthritis using cultured chondrocytes [33] and that pre-treatment with minocycline down-regulates pro-MMP expression after permanent cerebral ischemia [17].
Regulation (regulation) of Gene_expression (expression) of collagenase in chondrocytes associated with cv general 4 under development, ischemia and rheumatoid arthritis
1) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.70 Pain Relevance 0.21
Even though MMP-13 in rabbits is 90% and in mouse is 86% homologous to the human MMP-13 protein, it might be possible that the inhibitor designed against the human MMP-13 cannot inhibit the collagenases of other species to the same extent.17
Regulation (designed) of Neg (cannot) Gene_expression (cannot) of MMP-13
2) Confidence 0.43 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.51 Pain Relevance 0.32
Mechanical compression of the wound may induce excessive scarring and influence the release of PGE2 and the expression of collagenases.
Spec (may) Regulation (influence) of Gene_expression (expression) of collagenase associated with injury and keloid scars
3) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.96 Pain Relevance 0.27
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Regulation (dependent) of Gene_expression (Synthesis) of collagenase I associated with metalloproteinase
4) Confidence 0.15 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.26 Pain Relevance 0.05
However, activation of either MEK1 or MEK2 markedly up-regulated the expression of MMP-13 protein (Fig. 4A).
Regulation (regulated) of Gene_expression (expression) of MMP-13 protein
5) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.14 Pain Relevance 0.20
Despite an effect on the expression of c-Jun, as well as on the expression of MMP-1 and MMP-13, however, invasiveness of RA-SFs was not inhibited completely in the SCID mouse model.
Regulation (effect) of Gene_expression (expression) of MMP-13 associated with severe combined immunodeficiency and rheumatoid arthritis
6) Confidence 0.02 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 0.68 Pain Relevance 0.22

General Comments

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