INT170295

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 28.89
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
microglia 2
joint 1
macrophages 1
brain 1
dendritic cells 1
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 240 99.84 Very High Very High Very High
Inflammatory mediators 20 99.84 Very High Very High Very High
metalloproteinase 124 99.64 Very High Very High Very High
Arthritis 429 99.58 Very High Very High Very High
Demyelination 108 99.08 Very High Very High Very High
Inflammation 324 98.84 Very High Very High Very High
Multiple sclerosis 559 98.20 Very High Very High Very High
rheumatoid arthritis 134 96.52 Very High Very High Very High
depression 84 96.40 Very High Very High Very High
Serotonin 200 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 956 99.98 Very High Very High Very High
INFLAMMATION 387 99.84 Very High Very High Very High
Cancer 128 99.84 Very High Very High Very High
Disease 157 99.76 Very High Very High Very High
Arthritis 473 99.58 Very High Very High Very High
Chlamydia Infection 20 99.46 Very High Very High Very High
Infection 267 99.34 Very High Very High Very High
Anxiety Disorder 24 99.18 Very High Very High Very High
Adhesions 280 99.16 Very High Very High Very High
Demyelinating Disease 757 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induce IDO1 activity in vitro and in vivo [23], [28], [39].
Positive_regulation (induce) of IDO1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.47 Pain Relevance 0.15
Thus, IDO is thus expressed endogenously in various cell types and is induced during cell attachment to growth substrates.


Positive_regulation (induced) of IDO
2) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.32 Pain Relevance 0
These also induce IDO.
Positive_regulation (induce) of IDO
3) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.27 Pain Relevance 0.14
The results demonstrated that development of CIA was associated with increased IDO activity and enhanced tryptophan catabolism in mice.
Positive_regulation (increased) of IDO associated with arthritis
4) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 0.98 Pain Relevance 0.42
In cultured cells, the induction of IDO leads to depletion of tryptophan and tryptophan starvation.
Positive_regulation (induction) of IDO associated with starvation
5) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 0.37 Pain Relevance 0.13
Activity of IDO, as determined by measuring the levels of kynurenine/tryptophan ratio in the sera, was increased in the acute phase of arthritis and was higher in collagen-immunized mice that did not develop arthritis.
Positive_regulation (increased) of IDO associated with arthritis
6) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 1.00 Pain Relevance 0.43
The novel finding of our study is that IDO activity is upregulated in the acute phase of CIA reflected by the increased K/T ratio in the serum.
Positive_regulation (upregulated) of IDO associated with arthritis
7) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.32 Pain Relevance 0.45
These results showed that treatment of mice with the anti-CD137 antibody resulted in induction of IDO in vivo, which was associated with significant amelioration of the severity of CIA [26].
Positive_regulation (induction) of IDO associated with arthritis
8) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.92 Pain Relevance 0.38
Except for the last named tissue where IDO is expressed constitutively, IDO is inducible by inflammatory mediators, including interferons.
Positive_regulation (inducible) of IDO associated with inflammatory mediators
9) Confidence 0.45 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.23 Pain Relevance 0.09
Bringing together that bacterial products potentially induce IDO1 activity [20], [22], [28], [36] and that repeatedly stressed BALB/c mice show an increased bacterial burden, an anti-inflammatory cytokine bias and behavioral alteration as well as Trp shortage [7], [8], [13], we hypothesize that stress induces IDO1 activity.
Positive_regulation (induce) of IDO1 associated with stress, inflammation and cytokine
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.71 Pain Relevance 0.23
Our results suggest, that prolonged stressful experiences may aggravate the risk of suffer from infections in different disease states via IDO1 activation.
Positive_regulation (activation) of IDO1 associated with disease and infection
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.84 Pain Relevance 0.03
A role of cytokines in acute stress-induced IDO1 activation was studied after IFN?
Positive_regulation (activation) of IDO1 associated with stress and cytokine
12) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2911374 Disease Relevance 0.88 Pain Relevance 0.12
Finally, in a preliminary study with a small sample size and mostly male patients, we demonstrate that patients undergoing surgery who suffer from increased anxiety, helplessness and social isolation show IDO1 activation [49], [50].
Positive_regulation (activation) of IDO1 associated with anxiety disorder
13) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.79 Pain Relevance 0.04
Stress-induced IDO1 activation depends on IFN?
Positive_regulation (activation) of IDO1 associated with stress
14) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.59 Pain Relevance 0.08
Additional Trp catabolic pathways can be recruited by the activation of indoleamine 2,3-dioxygenase 1 (IDO1).
Positive_regulation (activation) of IDO1
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.71 Pain Relevance 0.13
antibody treatments blocked the induction of IDO1 mRNA in the brain (Fig. 2E) indicating that a proinflammatory response to stress is essential for IDO1 induction.
Positive_regulation (induction) of IDO1 mRNA in brain associated with stress
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.73 Pain Relevance 0.07
Moreover, there is increasing evidence that the activation of the IDO1-driven Trp catabolic pathway has clinical implication for humans: shown for sepsis or trauma [32], [33], depression [34], [35] and schizophrenia [34].
Positive_regulation (activation) of IDO1 associated with depression, injury, schizophrenia and sepsis
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.65 Pain Relevance 0.21
Bringing together that bacterial products potentially induce IDO1 activity [20], [22], [28], [36] and that repeatedly stressed BALB/c mice show an increased bacterial burden, an anti-inflammatory cytokine bias and behavioral alteration as well as Trp shortage [7], [8], [13], we hypothesize that stress induces IDO1 activity.
Positive_regulation (induces) of IDO1 associated with stress, inflammation and cytokine
18) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.69 Pain Relevance 0.24
Thus, activation of IDO1 activity was also measurable in patients who expected surgery and is even enhanced in the post-operative period which may contribute to postoperative immunosuppressive states.


Positive_regulation (activation) of IDO1
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.50 Pain Relevance 0
The impact of IDO1 activation in repeated stress-induced loss of the anti-bacterial defense is underlined by the yet preliminary findings that stressed IDO1?
Positive_regulation (activation) of IDO1 associated with stress
20) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.88 Pain Relevance 0.11

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