INT170296

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2011
Negated 15
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 12.49
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
neurons 6
CD86 4
saliva 4
livers 2
Kupffer cells 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 68 100.00 Very High Very High Very High
Ventral tegmentum 68 100.00 Very High Very High Very High
mu opioid receptor 17 100.00 Very High Very High Very High
Action potential 21 99.82 Very High Very High Very High
dexamethasone 52 96.80 Very High Very High Very High
c fibre 20 96.64 Very High Very High Very High
nociceptor 202 96.00 Very High Very High Very High
Nerve growth factor 58 96.00 Very High Very High Very High
metalloproteinase 83 95.52 Very High Very High Very High
opioid receptor 38 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 94 100.00 Very High Very High Very High
Sprains And Strains 73 100.00 Very High Very High Very High
Multiple Sclerosis 100 99.84 Very High Very High Very High
Apoptosis 207 99.46 Very High Very High Very High
Targeted Disruption 292 98.90 Very High Very High Very High
Cyst 3 98.80 Very High Very High Very High
Rheumatoid Arthritis 39 98.20 Very High Very High Very High
Stress 71 98.16 Very High Very High Very High
Coronary Artery Disease 6 97.80 Very High Very High Very High
Cancer 496 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the learned changes in VOR phase and gain were not equally affected by the disruption of P/Q signaling (Fig. 2), indicating some independence of the signaling pathways supporting the regulation of these two aspects of the movement by motor learning.
Neg (not) Regulation (affected) of Gene_expression (disruption) of Fig
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2572847 Disease Relevance 0 Pain Relevance 0
We also observed that during the time course of RA current sensitisation the magnitude of current injection required to evoke an AP was not changed in the presence of UTP (Fig. 4D).


Neg (not) Regulation (changed) of Gene_expression (presence) of Fig associated with action potential and rheumatoid arthritis
2) Confidence 0.27 Published 2009 Journal The Journal of Physiology Section Body Doc Link PMC2742277 Disease Relevance 0.27 Pain Relevance 0.73
Gold particles representing AMPA receptors were detected on the postsynaptic membrane of PF-PC synapses in both genotypes (Fig. 2F).
Regulation (detected) of Gene_expression (postsynaptic membrane) of Fig in synapses
3) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.08 Pain Relevance 0.31
Sodium salicylate also reduced Cox-2 promoter controlled transgene expression (Fig. 2e).
Regulation (controlled) of Gene_expression (expression) of Fig
4) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.31 Pain Relevance 0.20
Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5).
Neg (not) Regulation (affect) of Gene_expression (expression) of Fig in CD86
5) Confidence 0.23 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
After overlapping the associated genes of each TF, it can be seen that the altered activities of the three TFs (RunX1, MLXIPL and TRIM30) can be potentially responsible for 83% of the up-regulated mRNAs in saliva (Fig. 4G) whereas the collective altered activities of Egr1, Tbx1 and Nr1d1 can potentially account for 63% of the down-regulated expression of salivary mRNAs (Fig. 4H).


Regulation (regulated) of Gene_expression (expression) of Fig in saliva
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.94 Pain Relevance 0.20
After overlapping the associated genes of each TF, it can be seen that the altered activities of the three TFs (RunX1, MLXIPL and TRIM30) can be potentially responsible for 83% of the up-regulated mRNAs in saliva (Fig. 4G) whereas the collective altered activities of Egr1, Tbx1 and Nr1d1 can potentially account for 63% of the down-regulated expression of salivary mRNAs (Fig. 4H).


Regulation (regulated) of Gene_expression (expression) of Fig in saliva
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.94 Pain Relevance 0.19
-cat, Plako, ZO-1, Ocln, Cldn1, and Cldn12 were not modified in distribution and expression (Fig. 3 and not depicted).
Neg (not) Regulation (modified) of Gene_expression (expression) of Fig
8) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2575783 Disease Relevance 0.15 Pain Relevance 0
In parallel, to test whether VT680 activates cells in vivo, we measured levels of CD25 and CD44 expression on Thy1.2 (VT680+) and Thy1.1 (unstained) cells (Fig. 1J).
Regulation (levels) of Gene_expression (expression) of Fig
9) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.19 Pain Relevance 0.04
Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of Fig in neurons
10) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.13 Pain Relevance 0.41
Here we found that high level Ret expression and P2X3 expression were completely eliminated in IB4+ neurons in L-CKO mice (Fig. 1B), whereas their expression in IB4-negative neurons was largely unaffected (Fig. 1B).
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of Fig in neurons
11) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.12 Pain Relevance 0.41
7], p>0.05; Fig. 5B), but was reproduced in wild-type mice (control: 142.7±4.6% [n?
Regulation (control) of Gene_expression (reproduced) of Fig
12) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.20
CP2-KL (Fig. 6D) constructs all up-regulated endogenous Oprm1 gene expression in a dose-dependent manner.
Regulation (regulated) of Gene_expression (expression) of Fig
13) Confidence 0.18 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0.04
There were no significant differences in the expression level of other CaMKs between wild type mice and CaMKIV KO mice, suggesting that there were not any compensatory changes in the expression of these proteins (Fig. 1E).
Neg (not) Regulation (changes) of Gene_expression (expression) of Fig associated with targeted disruption
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.35 Pain Relevance 0.04
There was no change noted in the percentages of CD4+ T cells and CD8a+ T cells in the spleen (p>0.05, Fig. 4E–F) and M?
Regulation (percentages) of in T cells Gene_expression (p>0.05) of Fig in spleen
15) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.72 Pain Relevance 0
Ethanol administration decreased efficiency ratios and conditioned responses in wild-type mice but had no effect on mice lacking mu-opioid receptors (Fig. 4).
Neg (no) Regulation (effect) of Neg (lacking) Gene_expression (lacking) of Fig associated with mu opioid receptor
16) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635474 Disease Relevance 0.47 Pain Relevance 0.10
The IL-10 response in serum of GF mice was responsible for the enhanced response of Kupffer cells to LPS (Fig. 2).
Regulation (responsible) of Gene_expression (response) of Fig in Kupffer cells
17) Confidence 0.13 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.05 Pain Relevance 0.15
Of note, these authors detected a decrease in PKB/Akt phosphorylation on Ser473 with no apparent change in PKB/Akt expression in kidney cortex of Irs2-/- mice (Fig. 6A, C[24]).
Neg (no) Regulation (change) of Gene_expression (expression) of Fig in kidney cortex
18) Confidence 0.12 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.12 Pain Relevance 0
M may be the most efficacious concentration for regulating CD40 expression (Fig. 2C and 2D).
Regulation (regulating) of Gene_expression (expression) of Fig
19) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.18 Pain Relevance 0
However, neither injection of trpv4MO (Fig. 4, C and E) nor coinjection of trpv4MO in combination with low concentrations of pkd2MO resulted in a significant increase in cyst formation in the zebrafish pronephros (Fig. 4, D and F).
Neg (nor) Regulation (resulted) of Gene_expression (injection) of Fig in pronephros associated with cyst
20) Confidence 0.11 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.49 Pain Relevance 0

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