INT170299

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 2.59
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
P19 12
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 49 94.80 High High
Inflammation 59 94.40 High High
metalloproteinase 143 92.72 High High
COX-2 inhibitor 13 58.80 Quite High
tolerance 26 50.04 Quite High
Inflammatory mediators 26 37.84 Quite Low
cINOD 26 29.24 Quite Low
Serotonin 41 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 364 99.24 Very High Very High Very High
INFLAMMATION 99 94.40 High High
Stress 78 91.84 High High
Cytomegalovirus Infection 39 79.52 Quite High
Rheumatoid Arthritis 39 76.52 Quite High
Cancer 80 74.40 Quite High
Infection 24 47.20 Quite Low
Wound Healing 13 44.04 Quite Low
Necrosis 13 37.92 Quite Low
Bacterial Respiratory Disease 5 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inhibition of IDO gene expression correlated with increased expression of some but not all MMP genes in P19 cells undergoing aggregation.
Negative_regulation (inhibition) of Gene_expression (expression) of IDO gene in P19
1) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0.07
We observed a concentration dependent decrease in IDO expression in EGTA treated samples 24 hours after seeding, which paralleled a corresponding decrease in cell aggregation (Fig 4C).
Negative_regulation (decrease) of Gene_expression (expression) of IDO
2) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.24 Pain Relevance 0
Therefore, we investigated whether inhibition of IDO expression in the P19 in vitro aggregation system and the constitutive overexpression of IDO in RAW cells had any effect on MMP expression.
Spec (whether) Negative_regulation (inhibition) of Gene_expression (expression) of IDO in P19
3) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.05
Antisense inhibition of IDO expression
Negative_regulation (inhibition) of Gene_expression (expression) of IDO
4) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
Conversely, in P19 cell aggregates in which IDO expression was inhibited, there was a more dispersed phenotype with cells losing the ability to interact with each other.
Negative_regulation (inhibited) of Gene_expression (expression) of IDO in P19
5) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.23 Pain Relevance 0
Inhibition of endogenous IDO expression disrupts P19 cell adhesion
Negative_regulation (Inhibition) of Gene_expression (expression) of IDO in P19 associated with adhesions
6) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.32 Pain Relevance 0
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
Negative_regulation (diminished) of Gene_expression (transfectants) of IDO
7) Confidence 0.42 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.03
blockade prevented the up-regulation of IDO1 expression in acutely stressed mice.
Negative_regulation (prevented) of Gene_expression (expression) of IDO1
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.51 Pain Relevance 0.14
In particular, cell adhesion is altered dramatically by overexpressing IDO in cells which do not otherwise express it, or inhibiting IDO expression in cells in which it is naturally induced following cell passage.
Negative_regulation (inhibiting) of Gene_expression (expression) of IDO associated with adhesions
9) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.10 Pain Relevance 0
P19 cells in which endogenousIDO expression was disrupted by antisense expression, showed lower adhesiveness.
Negative_regulation (disrupted) of Gene_expression (expression) of endogenousIDO in P19
10) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.45 Pain Relevance 0.17
Therefore, we investigated whether inhibition of IDO expression in the P19 in vitro aggregation system and the constitutive overexpression of IDO in RAW cells had any effect on MMP expression.
Spec (whether) Negative_regulation (inhibition) of Gene_expression (overexpression) of IDO in P19
11) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.05
If uniformly diminished PG synthesis by IDO was responsible for growth of RAW cell macroscopic foci, inhibiting PG synthesis with a pharmacological inhibitor of COX-1 and -2 ought to reproduce the effect of IDO expression.
Negative_regulation (effect) of Gene_expression (expression) of IDO
12) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
We selected four clones with varying capacities for IDO expression and tryptophan depletion from culture medium (Fig 1B,C,D,E).
Negative_regulation (depletion) of Gene_expression (expression) of IDO
13) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.24 Pain Relevance 0
Therefore, the burst of IDO expression, which takes place in cells during reattachment does not result in substantial tryptophan depletion from culture medium
Negative_regulation (burst) of Gene_expression (expression) of IDO
14) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.06 Pain Relevance 0

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