INT170300

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 4.51
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Hmga2) enzyme binding (Hmga2) DNA binding (Hmga2)
mitosis (Hmga2) signal transduction (Hmga2) nucleus (Hmga2)
Anatomy Link Frequency
pituitary 12
thyroid 2
Hmga2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 9 58.40 Quite High
metalloproteinase 11 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 243 99.98 Very High Very High Very High
Targeted Disruption 99 99.88 Very High Very High Very High
Prolactinoma 27 99.60 Very High Very High Very High
Malignant Neoplastic Disease 9 99.00 Very High Very High Very High
Benign Tumor 9 95.16 Very High Very High Very High
Adenoma 36 87.76 High High
Cancer 33 77.48 Quite High
Retinoblastoma 18 74.88 Quite High
Hypopituitarism 9 59.08 Quite High
Headache 9 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, transgenic mice expressing high levels of the HMGA2 gene develop pituitary adenomas secreting prolactin and growth hormone [6], (Figure 1).
Positive_regulation (levels) of Gene_expression (expressing) of HMGA2 in pituitary associated with targeted disruption and pituitary cancer
1) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.86 Pain Relevance 0.06
By transfection, luciferase and colony assays, we could establish that the overexpression of HMGA2 antagonizes the activity of pRB.
Positive_regulation (overexpression) of Gene_expression (overexpression) of HMGA2
2) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.34 Pain Relevance 0
Consistently, HDAC1 activity associated to pRB is lower in cells and pituitary adenomas overexpressing HMGA2 than in mock-transfected cells and normal pituitary, respectively [38].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HMGA2 in pituitary associated with pituitary cancer
3) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.23 Pain Relevance 0
The presence of E2F1 hyperacetylation in the absence of HMGA2 overexpression would suggest the involvement of other proteins acting with the same or similar mechanism of HMGA2 protein, or alternatively other mechanisms that eventually lead to an increase in E2F1 acetylation and subsequent activation.



Positive_regulation (overexpression) of Gene_expression (overexpression) of HMGA2
4) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.35 Pain Relevance 0
Induction of HMGA2 gene expression occurs in several human malignant neoplasias, including thyroid [11,12], pancreas [13], breast [14], and colorectum [15-17], and seems to play a critical role in cell transformation, since the block of its synthesis prevents rat thyroid transformation by murine transforming retroviruses [18].
Positive_regulation (Induction) of Gene_expression (expression) of HMGA2 in thyroid associated with malignant neoplastic disease
5) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.66 Pain Relevance 0
To answer to this question, it would be interesting to evaluate the acetylation status of the E2F1 protein in pituitary adenomas when the HMGA2 is overexpressed or not.
Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of HMGA2 in pituitary associated with pituitary cancer
6) Confidence 0.68 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.36 Pain Relevance 0
E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression

The High Mobility Group protein HMGA2 is a nuclear architectural factor that plays a critical role in a wide range of biological processes including regulation of gene expression, embryogenesis and neoplastic transformation.

Positive_regulation (overexpression) of Gene_expression (overexpression) of HMGA2 in pituitary associated with pituitary cancer
7) Confidence 0.46 Published 2006 Journal Cell Div Section Title Doc Link PMC1563461 Disease Relevance 0.48 Pain Relevance 0
Consistent with the onset of pituitary adenomas in HMGA2-transgenic mice, we have found the induction of HMGA2 expression in human prolactinomas in association with amplification and/or rearrangement of the gene [20], and, recently, we have shown that also the majority of NFPAs express HMGA2, but, in these cases, it is not associated to over-representation of the HMGA2 region [21].


Positive_regulation (induction) of Gene_expression (expression) of HMGA2 in pituitary associated with targeted disruption, prolactinoma and pituitary cancer
8) Confidence 0.46 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.72 Pain Relevance 0
Overexpression of HMGA2 gene leads to the onset of prolactin and GH-hormone induced pituitary adenomas in mice, suggesting a critical role of this protein in pituitary tumorigenesis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of HMGA2 in pituitary associated with pituitary cancer
9) Confidence 0.46 Published 2006 Journal Cell Div Section Abstract Doc Link PMC1563461 Disease Relevance 0.52 Pain Relevance 0
If increased PG E2 production relative to other PGs was responsible for the appearance of macroscopic foci, then adding back increasing amounts of other PGs such as D2 and F2?
Positive_regulation (increased) of Gene_expression (production) of PG E2
10) Confidence 0.01 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0

General Comments

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