INT170305

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.70
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
macrophages 4
leukocytes 4
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 223 100.00 Very High Very High Very High
Central nervous system 106 100.00 Very High Very High Very High
Inflammation 122 94.76 High High
Arthritis 37 83.68 Quite High
dexamethasone 45 81.44 Quite High
Multiple sclerosis 50 80.36 Quite High
imagery 11 77.44 Quite High
Bioavailability 8 52.28 Quite High
cva 12 50.00 Quite Low
Inflammatory response 9 45.28 Quite Low
Disease Link Frequency Relevance Heat
Cancer 194 100.00 Very High Very High Very High
Breast Cancer 1 100.00 Very High Very High Very High
Multiple Sclerosis 140 99.58 Very High Very High Very High
Adhesions 56 98.32 Very High Very High Very High
Solid Tumor 13 98.32 Very High Very High Very High
Alzheimer's Dementia 32 98.00 Very High Very High Very High
INFLAMMATION 135 94.76 High High
Arthritis 53 92.20 High High
Mycobacterial Infection 49 90.84 High High
Colon Cancer 4 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, IR disruption in macrophages not only affected MMP-9 expression, but also translated into reduced MMP-9 activity.
Regulation (affected) of Gene_expression (expression) of MMP-9 in macrophages associated with metalloproteinase
1) Confidence 0.33 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.34 Pain Relevance 0.50
The combined treatment had a pronounced effect on MMP-9 detection, as compared to doxycycline treatment alone (29% and 40%, respectively, table 2).
Regulation (effect) of Gene_expression (detection) of MMP-9
2) Confidence 0.31 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.78 Pain Relevance 0.04
The relationship between CSF WCC and MMP-9 concentrations
Regulation (relationship) of Gene_expression (concentrations) of MMP-9
3) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.09 Pain Relevance 0.27
The total expression of MMP-9 within the CNS and by splenocytes, a robust biomarker of minocycline activity, was also equally effected by daily minocycline treatment and injections with PEG minocycline-liposomes every five days.
Regulation (effected) of Gene_expression (expression) of MMP-9 associated with metalloproteinase and central nervous system
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.41 Pain Relevance 0.43
Once in the tumor, E. coli for instance altered the tumor microenvironment in murine breast tumors by vascular remodeling, focal concentration of tumor associated macrophages and focal expression of MMP-9 and TNF-?
Regulation (altered) of Gene_expression (expression) of MMP-9 in macrophages associated with cancer and breast cancer
5) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724709 Disease Relevance 1.67 Pain Relevance 0
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Regulation (dependent) of Gene_expression (Synthesis) of gelatinase B associated with metalloproteinase
6) Confidence 0.19 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.26 Pain Relevance 0.05
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Regulation (dependent) of Gene_expression (Synthesis) of MMP-9 associated with metalloproteinase
7) Confidence 0.19 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.26 Pain Relevance 0.05
Effects of PEG minocycline-liposomes on the expression of MMP-9 in splenocytes and CNS-infiltrating leukocytes
Regulation (Effects) of Gene_expression (expression) of MMP-9 in leukocytes associated with metalloproteinase and central nervous system
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.54 Pain Relevance 0.41
In vitro effects of PEG minocycline-liposomes on MMP-9 expression by human PBMCs
Regulation (effects) of Gene_expression (expression) of MMP-9 associated with metalloproteinase
9) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.41 Pain Relevance 0.37
In contrast, neutralization of MDL-1 function down-regulates TRAP, cathepsin K, and MMP9 expression, subsequently preserving bone mineral density.
Regulation (regulates) of Gene_expression (expression) of MMP9
10) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.51 Pain Relevance 0.26
The principal goal of this study was to test the treatment efficacy of PEG minocycline-liposomes in EAE, and to study their effect on MMP-9 expression by leukocytes in peripheral lymphoid organs and the CNS.


Regulation (effect) of Gene_expression (expression) of MMP-9 in leukocytes associated with multiple sclerosis, metalloproteinase and central nervous system
11) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.44 Pain Relevance 0.41

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