INT170311

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.47
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
synovial fluids 1
P19 1
body 1
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 482 99.80 Very High Very High Very High
Inflammation 190 99.36 Very High Very High Very High
rheumatoid arthritis 120 99.32 Very High Very High Very High
Multiple sclerosis 124 99.00 Very High Very High Very High
Serotonin 40 97.64 Very High Very High Very High
depression 14 96.56 Very High Very High Very High
metalloproteinase 71 95.64 Very High Very High Very High
cytokine 97 90.64 High High
Demyelination 24 89.20 High High
tolerance 26 84.20 Quite High
Disease Link Frequency Relevance Heat
Arthritis 524 99.80 Very High Very High Very High
Adhesions 140 99.60 Very High Very High Very High
INFLAMMATION 231 99.36 Very High Very High Very High
Rheumatoid Arthritis 135 99.32 Very High Very High Very High
Demyelinating Disease 168 99.00 Very High Very High Very High
Stress 160 98.88 Very High Very High Very High
Cancer 68 98.68 Very High Very High Very High
Multiple Sclerosis 70 98.24 Very High Very High Very High
Disease 64 97.76 Very High Very High Very High
Depression 16 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the role of IDO in collagen-induced arthritis (CIA), a model of rheumatoid arthritis characterized by a primarily Th1-like immune response, activity of IDO was inhibited by 1-methyl-tryptophan (1-MT) in vivo.
Negative_regulation (inhibited) of IDO associated with rheumatoid arthritis and arthritis
1) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 0.86 Pain Relevance 0.36
Furthermore, we could also demonstrate that inhibition of IDO in this experimental model augments the incidence and severity of the disease and increases the immune responses to the autoantigens and alloantigens.
Negative_regulation (inhibition) of IDO associated with disease
2) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.43 Pain Relevance 0.50
Furthermore, pharmacological inhibition of IDO reversed the effects of the anti-CD137 antibody and aggravated the arthritis in this model.
Negative_regulation (inhibition) of IDO associated with arthritis
3) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.95 Pain Relevance 0.42
Blocking IDO1 activity abrogates chronic stress-induced immunosuppression
Negative_regulation (Blocking) of IDO1 associated with stress
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.96 Pain Relevance 0.15
In the case of RAW cells, IDO effects on cell growth could be reversed by adding back prostaglandins.


Negative_regulation (reversed) of IDO
5) Confidence 0.36 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC31925 Disease Relevance 0.47 Pain Relevance 0.14
Pharmacological inhibition of IDO results in pronounced inflammation, complement activation and fetal loss [17, 50].
Negative_regulation (inhibition) of IDO associated with inflammation
6) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.58 Pain Relevance 0.28
Furthermore, we reported that a pharmacologic inhibitor of IDO, 1-methyl tryptophan, induced maternal rejection of allogeneic but not syngeneic murine fetuses [17].
Negative_regulation (inhibitor) of IDO
7) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.36 Pain Relevance 0.04
It would be interesting to see whether IDO blockade could also prevent the spontaneous spreading of commensal bacteria into the body as shown in our previous studies [13].
Negative_regulation (blockade) of IDO in body
8) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.92 Pain Relevance 0.13
An alternative possibility was that a biologically active downstream catabolite of IDO could be the cause.
Negative_regulation (catabolite) of IDO
9) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.27 Pain Relevance 0.04
Inhibition of endogenous IDO expression disrupts P19 cell adhesion
Negative_regulation (disrupts) of IDO in P19 associated with adhesions
10) Confidence 0.36 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.32 Pain Relevance 0
Blocking IDO with 1-MT aggravated the severity of arthritis and enhanced the immune responses.
Negative_regulation (Blocking) of IDO associated with arthritis
11) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206348 Disease Relevance 0.96 Pain Relevance 0.41
Furthermore, agents that inhibit IDO are under active investigation as potential adjuvants for tumor immunotherapy [5].
Negative_regulation (inhibit) of IDO associated with cancer
12) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.84 Pain Relevance 0.21
To address the question of whether IDO plays a negative regulatory role in an animal model of arthritis, we assessed IDO activity in the sera of mice at different stages of arthritis and the effect of 1-methyl-tryptophan (1-MT), a specific inhibitor of IDO, on arthritis development and antigen-specific immune responses in CIA.


Negative_regulation (inhibitor) of IDO associated with arthritis
13) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.47 Pain Relevance 0.57
On the other hand, Zhu and colleagues [24] proposed that synovial T cells derived from RA synovial fluids are resistant to IDO-mediated tryptophan deprivation.
Negative_regulation (deprivation) of IDO in synovial fluids associated with rheumatoid arthritis
14) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.79 Pain Relevance 0.34
To confirm the regulatory role of IDO in CIA, we used 1-MT, a known competitive inhibitor of IDO. 1-MT did not influence IFN-?
Negative_regulation (inhibitor) of IDO associated with arthritis
15) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.02 Pain Relevance 0.41
The

tryptophan depleting enzyme indoleamine 2,3-dioxygenase (IDO) is also

Negative_regulation (depleting) of IDO
16) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.23 Pain Relevance 0.39
Inhibition of IDO activity
Negative_regulation (Inhibition) of IDO
17) Confidence 0.19 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 1.02 Pain Relevance 0.42

General Comments

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