INT170313

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 50
Total Number 58
Disease Relevance 38.53
Pain Relevance 21.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
fibroblast 7
Macrophage 2
chondrocytes 2
articular 2
synovial fluid 1
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1431 100.00 Very High Very High Very High
Inflammation 1049 99.62 Very High Very High Very High
Arthritis 832 99.52 Very High Very High Very High
rheumatoid arthritis 2212 99.40 Very High Very High Very High
Leflunomide 12 97.96 Very High Very High Very High
antagonist 95 97.44 Very High Very High Very High
cytokine 546 94.28 High High
methotrexate 196 93.84 High High
Osteoarthritis 310 93.28 High High
Kinase C 4 92.08 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 41 99.78 Very High Very High Very High
Severe Combined Immunodeficiency 174 99.72 Very High Very High Very High
INFLAMMATION 1031 99.62 Very High Very High Very High
Arthritis 889 99.52 Very High Very High Very High
Periodontitis 48 99.42 Very High Very High Very High
Rheumatoid Arthritis 2270 99.40 Very High Very High Very High
Down Syndrome 6 99.00 Very High Very High Very High
Stress 33 98.74 Very High Very High Very High
Osteoarthritis 309 98.60 Very High Very High Very High
Hypoxia 26 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The analysis of MMP-1 in mouse and rabbit models of arthritis is problematic because MMP-1 is present in rabbits and humans, but functionally absent in mice, whereas MMP-13 is present in all.16 17 Murine collagenase-like A (McolA) and McolB are counterparts of the human interstitial collagenase (MMP-1) with a high percentage of identities (58% in amino acids and 74% in nucleotides) but only present during mouse embryogenesis.
Gene_expression (counterparts) of McolA associated with arthritis
1) Confidence 0.65 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.65 Pain Relevance 0.26
Since in the non-inflammatory SCID mouse model, MMP-1 is only expressed constitutively by the implanted human cells, this might account for the higher efficiency of the MMP-13 inhibitor in this model.
Gene_expression (expressed) of MMP-1 associated with inflammation and severe combined immunodeficiency
2) Confidence 0.43 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.46 Pain Relevance 0.21
The analysis of MMP-1 in mouse and rabbit models of arthritis is problematic because MMP-1 is present in rabbits and humans, but functionally absent in mice, whereas MMP-13 is present in all.16 17 Murine collagenase-like A (McolA) and McolB are counterparts of the human interstitial collagenase (MMP-1) with a high percentage of identities (58% in amino acids and 74% in nucleotides) but only present during mouse embryogenesis.
Neg (absent) Gene_expression (absent) of MMP-1 associated with arthritis
3) Confidence 0.43 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.73 Pain Relevance 0.27
The analysis of MMP-1 in mouse and rabbit models of arthritis is problematic because MMP-1 is present in rabbits and humans, but functionally absent in mice, whereas MMP-13 is present in all.16 17 Murine collagenase-like A (McolA) and McolB are counterparts of the human interstitial collagenase (MMP-1) with a high percentage of identities (58% in amino acids and 74% in nucleotides) but only present during mouse embryogenesis.
Gene_expression (counterparts) of MMP-1 associated with arthritis
4) Confidence 0.37 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.75 Pain Relevance 0.28
The analysis of MMP-1 in mouse and rabbit models of arthritis is problematic because MMP-1 is present in rabbits and humans, but functionally absent in mice, whereas MMP-13 is present in all.16 17 Murine collagenase-like A (McolA) and McolB are counterparts of the human interstitial collagenase (MMP-1) with a high percentage of identities (58% in amino acids and 74% in nucleotides) but only present during mouse embryogenesis.
Neg (absent) Gene_expression (absent) of MMP-1 associated with arthritis
5) Confidence 0.37 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.73 Pain Relevance 0.27
Expression of MMP-13 and MMP-1 in the invasion process mediated by RASF
Gene_expression (Expression) of MMP-1
6) Confidence 0.33 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.74 Pain Relevance 0.20
In RA, the MMP inhibitor Trocade (Hoffmann-La Roche, Basel, Switzerland) with selectivity for the collagenase MMP-1 and the gelatinases (MMP-2 and MMP-9) was not efficacious.3 Another MMP-inhibitor BB-2827 (British Biotech, Oxford, UK) a collagenase-targeting hydroxamate, was studied in clinical phase I.22 To date, only the non-chelating MMP-13 inhibitor from Alantos Pharmaceuticals (Heidelberg, Germany) has reached preclinical testing phase.11
Gene_expression (selectivity) of MMP-1 associated with rheumatoid arthritis
7) Confidence 0.32 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.26 Pain Relevance 0.26
In addition, MMP-1 was highly expressed in the explants from the SCID-mouse co-implantation model (figure 1A–F).


Gene_expression (expressed) of MMP-1 associated with severe combined immunodeficiency
8) Confidence 0.29 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.73 Pain Relevance 0.16
Similarly, Manacu et al. [72] found that, in primary cultures of human osteoarthritic chondrocytes, the presence of ET-1 in the medium triggered increased production of MMP-1 and MMP-13.
Gene_expression (production) of MMP-1 in chondrocytes associated with osteoarthritis
9) Confidence 0.18 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.17
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
Gene_expression (expression) of MMP-1
10) Confidence 0.17 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.03
RAW transfectants over-expressing IDO showed reduced expression of collagenase I (MMP-1), and also bound less well to collagen-coated plates than controls.
Gene_expression (expression) of MMP-1
11) Confidence 0.17 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.04
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Gene_expression (levels) of MMP-1 associated with premature birth
12) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.76 Pain Relevance 0.16
We also compared levels of MMP-1 in LPS-induced mice that were treated with RNAi directed at ECE-1 to levels of the protein in positive control LPS-induced mice with unaltered ET-1 systems.
Gene_expression (levels) of MMP-1
13) Confidence 0.16 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.83 Pain Relevance 0.21
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Gene_expression (Synthesis) of MMP-1 associated with metalloproteinase
14) Confidence 0.15 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.25 Pain Relevance 0.05
In ET-1-activated human optic nerve head astrocytes, levels of MMP-1, TIMP-1, and TIMP-2 are all increased.
Gene_expression (levels) of MMP-1 in astrocytes
15) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.54 Pain Relevance 0.17
Normal fibroblasts produce very low levels of MMP-1 and MMP-3.
Gene_expression (produce) of MMP-1 in fibroblasts
16) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.68 Pain Relevance 0.61
, specifically their ability to produce MMP-1 and MMP-3.
Gene_expression (produce) of MMP-1 associated with metalloproteinase
17) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.81 Pain Relevance 0.62
DMSO for 24 hours, before harvesting total RNA and determining expression of various MMP genes, including stromelysins 1 (MMP-3), 2 (MMP-10) and 3 (MMP-11), collagenases I (MMP-1) and IV (MMP-2) and meltrins ?
Spec (determining) Gene_expression (expression) of MMP-1
18) Confidence 0.11 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.08 Pain Relevance 0.04
Normal fibroblasts produce very low levels of MMP-1 and MMP-3.
Gene_expression (produce) of MMP-1 in fibroblasts
19) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.68 Pain Relevance 0.61
Transgenic mice over-expressing MMP-1 in the lung develop enlarged airspaces (D’Armiento et al 1992), which may either reflect abnormal alveolar development or destruction of mature interstitial collagens by MMP-1.
Gene_expression (expressing) of MMP-1 in lung associated with targeted disruption
20) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.04 Pain Relevance 0.55

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