INT170314

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Context Info
Confidence 0.18
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col4a1) proteinaceous extracellular matrix (Col4a1)
Anatomy Link Frequency
macrophages 2
RAW 264 2
fibroblasts 2
thymus 2
Col4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1 100.00 Very High Very High Very High
fibrosis 24 98.64 Very High Very High Very High
Inflammatory mediators 8 96.52 Very High Very High Very High
Inflammation 37 77.04 Quite High
cINOD 8 74.24 Quite High
cytokine 40 57.84 Quite High
metalloproteinase 54 54.36 Quite High
Pain 2 50.76 Quite High
tolerance 8 31.52 Quite Low
COX-2 inhibitor 4 14.48 Low Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 67 98.92 Very High Very High Very High
Fibrosis 23 98.64 Very High Very High Very High
Adhesions 112 97.40 Very High Very High Very High
INFLAMMATION 49 96.12 Very High Very High Very High
Apoptosis 21 92.20 High High
Cancer 35 84.00 Quite High
Necrosis 11 83.52 Quite High
Renal Disease 1 78.56 Quite High
Disease 22 78.44 Quite High
Inflammatory Bowel Disease 1 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of IDO-expressing RAW clones with a known inducer of COX-2 (LPS), revealed a lack of correlation between COX-2 RNA and protein levels.
Positive_regulation (inducer) of Gene_expression (clones) of RAW
1) Confidence 0.18 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.28 Pain Relevance 0.15
Specifically, overexpression of IDO in RAW and MC57 cells resulted in the growth of macroscopic foci and other phenotypic alterations.
Positive_regulation (overexpression) of Gene_expression (overexpression) of RAW
2) Confidence 0.18 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.14 Pain Relevance 0
Therefore, we treated IDO transfected RAW cells and controls with LPS and measured COX-2 expression 24 hours later.
Positive_regulation (transfected) of Gene_expression (transfected) of RAW
3) Confidence 0.18 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
We transfected the murine macrophage cell line RAW 264.7 with a construct in which IDO was expressed under the control of the murine MHC Class II promoter (Fig 1A).
Positive_regulation (transfected) of Gene_expression (transfected) of RAW in RAW 264
4) Confidence 0.18 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.40 Pain Relevance 0.08
The finding that the synthesis of type IV collagen, a major collagen type in basement membrane, is disproportionately increased in the dermal fibroblasts and sera of patients with SSc supports this notion [4,5].
Positive_regulation (increased) of Gene_expression (synthesis) of type IV collagen in fibroblasts associated with systemic sclerosis
5) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.32 Pain Relevance 0.12
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Positive_regulation (enhanced) of Gene_expression (expression) of type IV collagen in thymus associated with chemokine
6) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.28 Pain Relevance 0.05
We found that lipopolysaccharide (LPS) stimulation of mouse Raw 264.7 macrophages resulted in the upregulation of miR-155 and downregulation of miR-125b levels.
Positive_regulation (stimulation) of Gene_expression (macrophages) of Raw in macrophages
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.09 Pain Relevance 0.09

General Comments

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