INT170315

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 25.39
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
brain 8
epididymis 7
T cells 6
liver 3
macrophages 2
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 308 99.32 Very High Very High Very High
metalloproteinase 296 98.92 Very High Very High Very High
Inflammation 460 98.80 Very High Very High Very High
Inflammatory mediators 60 97.12 Very High Very High Very High
rheumatoid arthritis 99 95.40 Very High Very High Very High
Serotonin 277 94.88 High High
abatacept 5 94.48 High High
depression 105 94.44 High High
cytokine 311 93.60 High High
Multiple sclerosis 307 93.52 High High
Disease Link Frequency Relevance Heat
Stress 1180 99.98 Very High Very High Very High
Adhesions 732 99.92 Very High Very High Very High
Cancer 212 99.84 Very High Very High Very High
Inflammatory Bowel Disease 30 99.84 Very High Very High Very High
Multiple Sclerosis 326 99.74 Very High Very High Very High
Infection 203 99.36 Very High Very High Very High
Arthritis 331 99.32 Very High Very High Very High
INFLAMMATION 576 98.80 Very High Very High Very High
Fibrosarcoma 52 97.56 Very High Very High Very High
Starvation 23 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently confirmed that IDO expression in RAW cells following cell passage is likewise important for correct cell adhesion (results not shown).
Positive_regulation (important) of Gene_expression (expression) of IDO associated with adhesions
1) Confidence 0.67 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.26 Pain Relevance 0
Although, we did not determine the cell population which induced IDO1 expression in our study, it was recently shown that IDO1 protein is detectable in a number of cells and tissues such as antigen-presenting cells of epididymis, placenta, spleen, thymus, lung and digestive tract [38] which remains to be investigated in the murine stress model.
Positive_regulation (induced) of Gene_expression (expression) of IDO1 in epididymis associated with stress
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.45 Pain Relevance 0.09
caused time-dependent induction of IDO gene expression and activity in cultured normal fibroblasts [4].
Positive_regulation (induction) of Gene_expression (expression) of IDO gene in fibroblasts
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.63 Pain Relevance 0.15
Expression of the IDO gene is induced in most cell types in response to infection with microbial agents via activation of toll-like receptors.
Positive_regulation (induced) of Gene_expression (Expression) of IDO gene associated with infection
4) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.84 Pain Relevance 0.18
Therefore, IDO expression appeared to be induced by reattachment, rather than detachment from a previous substrate.
Positive_regulation (induced) of Gene_expression (expression) of IDO
5) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.30 Pain Relevance 0
As previously mentioned, tryptophan is not significantly depleted in culture medium of RAW cells overexpressing IDO, suggesting that tryptophan deprivation is not the cause of the IDO effect.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IDO
6) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.28 Pain Relevance 0.10
Specifically, overexpression of IDO in RAW and MC57 cells resulted in the growth of macroscopic foci and other phenotypic alterations.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO
7) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.14 Pain Relevance 0
Therefore, we investigated whether inhibition of IDO expression in the P19 in vitro aggregation system and the constitutive overexpression of IDO in RAW cells had any effect on MMP expression.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO in P19
8) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.04
Therefore, we tested the tryptophan catabolites, picolinic acid and quinolinic acid to see if they could reproduce the effects of IDO overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO
9) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.31 Pain Relevance 0.04
IDO expression is induced during cell attachment to growth substrates
Positive_regulation (induced) of Gene_expression (expression) of IDO
10) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.25 Pain Relevance 0
However, in cells detached from their normal growth substrate, IDO expression was already induced by 5 hours following reseeding into fresh tissue culture dishes and expression was detected until 48 hours (Fig 4A).
Positive_regulation (induced) of Gene_expression (expression) of IDO
11) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.28 Pain Relevance 0
Therefore, we treated IDO transfected RAW cells and controls with LPS and measured COX-2 expression 24 hours later.
Positive_regulation (transfected) of Gene_expression (transfected) of IDO
12) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
PG E2 was the dominant prostaglandin (Fig 7B) and overexpression of IDO resulted in a relative increase in the amount of PG D2 and other PGs, relative to E2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO
13) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.12 Pain Relevance 0.03
However, IDO overexpressing clone 26 showed a reduced amount of COX-2 protein compared to the vector only control (Fig 8C).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IDO
14) Confidence 0.59 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
is the increased expression of IDO by non-T cells [21].
Positive_regulation (increased) of Gene_expression (expression) of IDO in T cells
15) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.01 Pain Relevance 0.45
Thus IDO overexpression resulted in an increase in PG E2 relative to the other PGs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO
16) Confidence 0.49 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.04
Therefore, we investigated the circumstances under which IDO is expressed in vitro together with the effects of overexpression of IDO on the growth and morphology of cells.


Positive_regulation (overexpression) of Gene_expression (overexpression) of IDO
17) Confidence 0.45 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC31925 Disease Relevance 0.48 Pain Relevance 0.16
Acute stress-induced up-regulation of IDO expression is likely linked to increased dissemination of commensal bacteria into mesenteric lymph nodes and liver which provokes a transiently increased proinflammatory cytokine bias in acutely stressed mice [37].
Positive_regulation (regulation) of Gene_expression (expression) of IDO in liver associated with stress and cytokine
18) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.48 Pain Relevance 0.13
In this study, we show for the first time that already an acute stress exposure causes a rapid up-regulation of IDO1 mRNA expression in different organs – most prominently in the brain.
Positive_regulation (causes) of Gene_expression (expression) of IDO1 mRNA in brain associated with stress
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.50 Pain Relevance 0
Indeed, we found transiently increased IDO1 mRNA expression in several tissues (whole organ homogenates) with a highest response in the brain (14.17±3.83-fold) 6-h after acute stress (Fig. 2A).
Positive_regulation (increased) of Gene_expression (expression) of IDO1 mRNA in brain associated with stress
20) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.68 Pain Relevance 0.05

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