INT170318

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.63
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
colon 1
bile 1
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 33 99.96 Very High Very High Very High
Bile 1 98.68 Very High Very High Very High
Inflammation 90 82.16 Quite High
cva 1 61.56 Quite High
Serotonin 21 60.80 Quite High
interstitial cystitis 3 51.24 Quite High
Inflammatory mediators 10 41.64 Quite Low
cytokine 38 20.68 Low Low
tolerance 11 5.00 Very Low Very Low Very Low
depression 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 85 99.64 Very High Very High Very High
Colitis 39 99.24 Very High Very High Very High
Cancer 46 89.44 High High
Death 5 88.16 High High
Stress 78 86.40 High High
INFLAMMATION 107 82.16 Quite High
Disease 8 74.96 Quite High
Infection 15 74.12 Quite High
Disease Progression 1 69.60 Quite High
Anxiety Disorder 2 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IDO axpression alters metalloproteinase expression
Regulation (alters) of IDO associated with metalloproteinase
1) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.17 Pain Relevance 0.05
IDO-transfected RAW cell clones, which expressed IDO under the control of the MHC Class II promoter, were characterized for IDO expression.
Regulation (characterized) of IDO-transfected
2) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.37 Pain Relevance 0.03
Since Kyna can be produced by commensal bacteria and is found in pancreatic and bile juices [47], [48] formation of the molecule does not essentially dependent on IDO1 activity.
Neg (not) Regulation (dependent) of IDO1 in bile associated with bile
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.74 Pain Relevance 0.05
and IDO was not altered in the colon upon colitis induction.
Neg (not) Regulation (altered) of IDO in colon associated with colitis
4) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.40 Pain Relevance 0.08
To understand the mechanism of IDO induced alterations in cell adhesion and MMP expression, we attempted to reverse IDO effects on cell adhesion.
Regulation (alterations) of IDO associated with adhesions
5) Confidence 0.23 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.29 Pain Relevance 0.10
Finally, Network 9 has IL6 in a central position and genes such as INDO that is a known target of IFN-?.
Regulation (target) of INDO
6) Confidence 0.08 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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