INT170319

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.72
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
fibroblast 2
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 82 100.00 Very High Very High Very High
rheumatoid arthritis 154 94.60 High High
antagonist 9 61.88 Quite High
Inflammation 26 49.48 Quite Low
Inflammatory mediators 4 38.96 Quite Low
Dismenorea 1 33.24 Quite Low
Kinase C 1 26.72 Quite Low
Osteoarthritis 34 20.80 Low Low
methotrexate 32 12.48 Low Low
cytokine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 56 98.32 Very High Very High Very High
Premature Birth 40 97.88 Very High Very High Very High
Rheumatoid Arthritis 160 94.60 High High
Congenital Anomalies 9 89.84 High High
Pre-term Labor 13 80.64 Quite High
Infection 37 75.36 Quite High
Osteoarthritis 35 68.32 Quite High
Hypertension 3 64.20 Quite High
Recurrence 4 58.64 Quite High
Osteogenic Sarcomas 1 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Regulation (consequently) of Gene_expression (levels) of MMP-1 associated with premature birth
1) Confidence 0.11 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.76 Pain Relevance 0.16
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
Regulation (explain) of Gene_expression (expression) of MMP-1
2) Confidence 0.10 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.03
Synthesis of MMPs such as collagenase I (MMP-1), gelatinase B (MMP-9) and matrilysin (MMP-7) has been shown to be dependent on the synthesis of PG E2, suggesting that alterations in MMP expression may be instigated by alterations in PG synthesis [27,28,29,30].
Regulation (dependent) of Gene_expression (Synthesis) of MMP-1 associated with metalloproteinase
3) Confidence 0.10 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.26 Pain Relevance 0.05
B plays an important role in signal transduction and expression of a variety of genes, including MMP-1, under the influence of TNF-?
Regulation (role) of Gene_expression (expression) of MMP-1 associated with metalloproteinase
4) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.84 Pain Relevance 0.51
B1 markedly suppressed the generation of fibroblast-like cells as well as the production of MMP-1 and VEGF under the influence of TNF-?
Regulation (under) of Gene_expression (production) of MMP-1 in fibroblast associated with metalloproteinase
5) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.73 Pain Relevance 0.36

General Comments

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