INT170321

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.54
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
neuroblast 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 29 86.40 High High
rheumatoid arthritis 60 81.52 Quite High
Arthritis 66 79.52 Quite High
Inflammation 32 74.32 Quite High
cytokine 3 43.36 Quite Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Severe Combined Immunodeficiency 28 84.40 Quite High
Rheumatoid Arthritis 63 81.52 Quite High
Arthritis 68 79.52 Quite High
Wound Healing 1 77.84 Quite High
Adhesions 32 75.60 Quite High
INFLAMMATION 35 74.32 Quite High
Suicidal Behaviour 27 65.88 Quite High
Disease 12 63.20 Quite High
Apoptosis 75 62.12 Quite High
Infection 1 52.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since type-1 collagen engages integrins, we used Collagenase-A to disrupt neuroblast interactions with the extra-cellular collagen matrix.
Collagenase Binding (interactions) of in neuroblast
1) Confidence 0.36 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.31 Pain Relevance 0.03
In this study, we analysed a novel highly selective MMP-13 inhibitor which differs from previous MMP inhibitors, because it does not bind to the catalytic zinc ion and is non-competitive with respect to substrate binding.7 Unlike other MMP inhibitors this novel MMP-13 inhibitor binds deeply into the S1?
MMP-13 Binding (binds) of
2) Confidence 0.34 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.00 Pain Relevance 0.46
pocket and interacts with residues in the MMP-13 specificity loop to gain remarkable selectivity.
MMP-13 Binding (interacts) of
3) Confidence 0.29 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.03 Pain Relevance 0.47
These include motifs for transcription factors that bind to collagenase and elastase genes and motifs for the transcription factor MEP-1, which regulates transcription from the stromelysin-1 (MMP-3) and metallothionein genes [18,19].
collagenase Binding (bind) of
4) Confidence 0.16 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.20 Pain Relevance 0.12

General Comments

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