INT170323

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 11
Total Number 19
Disease Relevance 8.74
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
liver 3
P19 2
Th1 cells 2
brain 2
mesenteric lymph nodes 1
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 125 99.96 Very High Very High Very High
Serotonin 97 99.60 Very High Very High Very High
Arthritis 121 99.40 Very High Very High Very High
Inflammation 121 97.96 Very High Very High Very High
Demyelination 12 97.32 Very High Very High Very High
cINOD 22 96.32 Very High Very High Very High
rheumatoid arthritis 32 94.20 High High
cytokine 100 94.12 High High
Multiple sclerosis 62 94.04 High High
tolerance 26 93.72 High High
Disease Link Frequency Relevance Heat
Cancer 85 99.88 Very High Very High Very High
Stress 392 99.76 Very High Very High Very High
Frailty 5 99.48 Very High Very High Very High
Arthritis 132 99.40 Very High Very High Very High
Adhesions 308 99.36 Very High Very High Very High
Lymphopenia 5 98.88 Very High Very High Very High
INFLAMMATION 165 97.96 Very High Very High Very High
Arthropathy 8 97.44 Very High Very High Very High
Demyelinating Disease 84 97.32 Very High Very High Very High
Autoimmune Disease 16 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the role of IDO expression in P19 cells, we transfected P19 cells with a DNA construct which contained a 740 bp fragment of murine IDO cDNA in the antisense orientation, under the control of the constitutively active CMV promoter in the pcDNA-3 mammalian expression vector.
Spec (examine) Regulation (role) of Gene_expression (expression) of IDO in P19 associated with cytomegalovirus infection
1) Confidence 0.60 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.33 Pain Relevance 0
blockade prevented the up-regulation of IDO1 expression in acutely stressed mice.
Regulation (regulation) of Gene_expression (expression) of IDO1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.51 Pain Relevance 0.14
As tryptophan is not the only substrate for IDO, we also investigated whether adding serotonin would overcome the effects of IDO expression.
Spec (whether) Regulation (effects) of Gene_expression (expression) of IDO associated with serotonin
3) Confidence 0.52 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.24 Pain Relevance 0.05
Picolinic acid (1-6 mM) produced morphological changes in both MC57 and RAW cells and also substantial reductions in growth rate but did not mimic the effects of IDO expression.
Neg (not) Regulation (effects) of Gene_expression (expression) of IDO
4) Confidence 0.52 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.32 Pain Relevance 0.07
Indeed, modulation of cellular IDO expression and/or activity is now increasingly implicated in inflammation and autoimmunity, organ transplantation and fetal rejection, and evasion of immune surveillance by tumor cells.
Regulation (modulation) of Gene_expression (expression) of IDO associated with autoimmune disease, inflammation, cancer and organ transplantation
5) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.96 Pain Relevance 0.28
Acute stress-induced up-regulation of IDO expression is likely linked to increased dissemination of commensal bacteria into mesenteric lymph nodes and liver which provokes a transiently increased proinflammatory cytokine bias in acutely stressed mice [37].
Regulation (regulation) of Gene_expression (expression) of IDO in liver associated with stress and cytokine
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.48 Pain Relevance 0.13
release of splenocytes (Fig. 4B), lymphocytopenia (Fig. 4C), and thymic atrophy (Fig. 4D) which were not affected by IDO1 blockade.
Neg (not) Regulation (affected) of Gene_expression (blockade) of IDO1 associated with lymphopenia and frailty
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.66 Pain Relevance 0
IDO-transfected RAW cell clones, which expressed IDO under the control of the MHC Class II promoter, were characterized for IDO expression.
Regulation (characterized) of Gene_expression (expression) of IDO
8) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.25 Pain Relevance 0
The alterations in COX-2 expression observed in IDO-expressing RAW and MC57 cells are a particularly interesting feature of our results.
Regulation (alterations) of Gene_expression (expression) of IDO-expressing
9) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.10
Thus IDO expression does not mimic the effects of a global COX inhibitor.
Neg (not) Regulation (effects) of Gene_expression (expression) of IDO
10) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
This suggests that COX-2 RNA and/or protein turnover may be affected by IDO expression.
Spec (may) Regulation (affected) of Gene_expression (expression) of IDO
11) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.34 Pain Relevance 0.21
IDO axpression alters metalloproteinase expression
Regulation (alters) of Gene_expression (axpression) of IDO associated with metalloproteinase
12) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.17 Pain Relevance 0.05
MC57 cells, which demonstrated similar changes in cell adhesion to RAW cells following IDO expression, exhibited lower levels of COX-2 synthesis upon IDO expression and lower levels of PG E2 relative to other PGs such as D2.
Regulation (synthesis) of Gene_expression (expression) of IDO associated with adhesions
13) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.30 Pain Relevance 0.03
Ectopic expression studies reveal that even small changes in expression of IDO, HMOX-1, or mitochondrial superoxide dismutase (SOD2) can prevent demyelination in experimental autoimmune encephalomyelitis (EAE) animal models of MS.
Regulation (changes) of Gene_expression (expression) of IDO associated with multiple sclerosis and demyelination
14) Confidence 0.32 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2683338 Disease Relevance 0.85 Pain Relevance 0.28
In this study, we show for the first time that already an acute stress exposure causes a rapid up-regulation of IDO1 mRNA expression in different organs – most prominently in the brain.
Regulation (regulation) of Gene_expression (expression) of IDO1 mRNA in brain associated with stress
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.50 Pain Relevance 0
The importance of IDO activity in the regulation of CIA supports the hypothesis that IDO expression by antigen-presenting cells is responsible for suppression of undesirable Th1 cells in human inflammatory joint diseases, as tryptophan degradation could be demonstrated in patients with RA [28].
Regulation (responsible) of Gene_expression (expression) of IDO in Th1 cells associated with inflammation, rheumatoid arthritis, arthropathy and arthritis
16) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.23 Pain Relevance 0.56
We have observed IDO expression routinely in murine tumors in vivo, and are presently investigating the growth properties of tumors with altered IDO expression.
Spec (investigating) Regulation (altered) of Gene_expression (expression) of IDO associated with cancer
17) Confidence 0.23 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.64 Pain Relevance 0.29
IDO-transfected RAW cell clones, which expressed IDO under the control of the MHC Class II promoter, were characterized for IDO expression.
Regulation (under) of Gene_expression (expressed) of IDO
18) Confidence 0.23 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.36 Pain Relevance 0.03
Acute stress-induced up-regulation of IDO expression is likely linked to increased dissemination of commensal bacteria into mesenteric lymph nodes and liver which provokes a transiently increased proinflammatory cytokine bias in acutely stressed mice [37].
Regulation (regulation) of in mesenteric lymph nodes Gene_expression (expression) of IDO in liver associated with stress and cytokine
19) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.48 Pain Relevance 0.13

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