INT17033

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 11.76
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Trf) transport (Trf) mitochondrion (Trf)
extracellular space (Trf) extracellular region (Trf) cytoplasmic membrane-bounded vesicle (Trf)
Anatomy Link Frequency
blood 1
plasma 1
erythrocyte 1
lymphocyte 1
brain 1
Trf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 44 99.96 Very High Very High Very High
rheumatoid arthritis 3 99.84 Very High Very High Very High
dopamine receptor 1 99.68 Very High Very High Very High
spinal inflammation 2 99.16 Very High Very High Very High
antagonist 5 98.96 Very High Very High Very High
abdominal pain 6 97.16 Very High Very High Very High
opiate 9 95.28 Very High Very High Very High
Pain 7 93.00 High High
medulla 1 90.00 High High
imagery 232 87.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 43 99.96 Very High Very High Very High
Liver Disease 15 99.92 Very High Very High Very High
Rheumatoid Arthritis 3 99.84 Very High Very High Very High
Disease 41 99.60 Very High Very High Very High
Hepatocellular Cancer 2 99.60 Very High Very High Very High
Low Back Pain 2 99.16 Very High Very High Very High
Prolactinoma 2 98.80 Very High Very High Very High
Chronic Fatigue Syndrome 2 98.68 Very High Very High Very High
Arthralgia 5 98.54 Very High Very High Very High
Anaemia 65 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice.
Positive_regulation (Increased) of transferrin in plasma associated with hypochromic anemia
1) Confidence 0.62 Published 2007 Journal Blood Section Title Doc Link 17003376 Disease Relevance 0.73 Pain Relevance 0.09
However, in contrast to control cells, Tfn was not transported to the ERC after internalization, but remained inside EEs (?
Positive_regulation (transported) of Tfn
2) Confidence 0.30 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
The hemoglobin levels, the erythrocyte mean cell volume, serum iron levels, the increase in transferrin levels, the decrease in the percent transferrin saturation, ferritin levels, the nutritional status, and the CRP and serum amyloid A levels were measured.
Positive_regulation (increase) of transferrin in erythrocyte
3) Confidence 0.28 Published 2002 Journal Ital Heart J Section Body Doc Link 11974664 Disease Relevance 0.08 Pain Relevance 0
We report on a 62-year-old patient with arthralgia, pathologic glucose metabolism, brown skin pigmentation and excessively elevated ferritin and transferrin saturation levels, which initially were interpreted as signs of the assumed underlying disease (hemo-chromatosis) based on a high initial suspicion level and further corroborated by Bayesian probability analysis yielding a probability 99.0 % for the presence of hemochromatosis.
Positive_regulation (elevated) of transferrin in pigmentation associated with arthralgia, iron overload and disease
4) Confidence 0.25 Published 2002 Journal Z Gastroenterol Section Abstract Doc Link 11961734 Disease Relevance 0.80 Pain Relevance 0
Finally, the deficiency of folic acid absorption can be assumed to be caused by the symptoms of the disease, whereas in the case of inflammatory diseases and in mixed group transferrin increased.
Positive_regulation (increased) of transferrin associated with inflammation and disease
5) Confidence 0.25 Published 1980 Journal Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. Section Abstract Doc Link 6162734 Disease Relevance 0.72 Pain Relevance 0.18
Transferrin ankylosing spondylitis is similar to that of controls, however, transferrin increases in rheumatoid arthritis and in mixed groups containing patients various diseases.
Positive_regulation (increases) of transferrin associated with spinal inflammation, rheumatoid arthritis and disease
6) Confidence 0.25 Published 1980 Journal Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. Section Abstract Doc Link 6162734 Disease Relevance 0.47 Pain Relevance 0.19
The level of transferrin saturation was increased in 6% of heterozygotes but only 1% had serum ferritin concns greater than 350 ng ml-1.
Positive_regulation (increased) of transferrin
7) Confidence 0.13 Published 1983 Journal Clin Invest Med Section Abstract Doc Link 6652983 Disease Relevance 0.39 Pain Relevance 0.09
It is known that some transport molecules such as growth factors, insulin and transferrin can potentially increase the efficiency and kinetics of drugs across a range of tissues.
Positive_regulation (increase) of transferrin
8) Confidence 0.13 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.51 Pain Relevance 0.33
Repeated weekly administration of ferric carboxymaltose does not result in accumulation of transferrin iron in patients with iron-deficiency anaemia.
Positive_regulation (accumulation) of transferrin associated with anaemia
9) Confidence 0.12 Published 2009 Journal Drugs Section Abstract Doc Link 19405553 Disease Relevance 0.71 Pain Relevance 0.04
Most importantly, we observed statistically significant increases in serum albumin (P < 0.0001), moderately significant increase in serum transferrin (P < 0.07) (Table 1), improvement in functional status and physical activity with no toxicity related to the study drug at this dose.
Positive_regulation (increase) of transferrin associated with toxicity
10) Confidence 0.10 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.32 Pain Relevance 0.13
Osguthorope follows serum hemoglobin, transferrin, prealbumin, and albumin levels.
Positive_regulation (follows) of transferrin
11) Confidence 0.10 Published 1991 Journal Head Neck Section Abstract Doc Link 1869441 Disease Relevance 0.44 Pain Relevance 0.06
Ascorbic acid increases the intracellular labile iron pool and iron mobilization to transferrin in human hepatoma HepG2 cells only in the presence of iron sucrose but not in the presence of iron dextran or ferric gluconate [92].
Positive_regulation (increases) of transferrin associated with hepatocellular cancer
12) Confidence 0.09 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.71 Pain Relevance 0.04
Using a in vitro model of the BBB and in situ brain perfusion, they demonstrated that these peptides, and in particular Angiopep-2, exhibited higher transcytosis capacity and parenchymal accumulation than other receptors such as transferrin, lactoferrin, and avidin.
Positive_regulation (accumulation) of transferrin in brain
13) Confidence 0.09 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.18 Pain Relevance 0
However, evidence for a glycosylation disorder was substantiated by an increased carbohydrate deficient transferrin (CDT).
Positive_regulation (increased) of transferrin
14) Confidence 0.06 Published 2001 Journal Eur. J. Paediatr. Neurol. Section Abstract Doc Link 11589167 Disease Relevance 2.04 Pain Relevance 0.19
Old-old patients presented with laboratory data of malnutrition (decreased serum levels of albumin, cholesterol, hemoglobin, hematocrit, lymphocyte count) and inflammation (increased of transferrin and C-reactive protein).
Positive_regulation (increased) of transferrin in lymphocyte associated with appetite loss and inflammation
15) Confidence 0.05 Published 2005 Journal Arch Gerontol Geriatr Section Abstract Doc Link 15814166 Disease Relevance 0.85 Pain Relevance 0.21
On the other hand, serum transferrin saturation percent was elevated in only Yanbu firefighters, (p < 0.05) as compared to Jeddah firefighters.
Positive_regulation (elevated) of transferrin
16) Confidence 0.05 Published 2009 Journal J Occup Med Toxicol Section Abstract Doc Link PMC2713944 Disease Relevance 0 Pain Relevance 0
On the other hand, serum transferrin saturation percent was elevated in only Yanbu firefighters, (p < 0.05) as compared the Jeddah firefighters, there was no statistically significant change in blood hemoglobin and serum iron comparing all studies group.
Positive_regulation (elevated) of transferrin in blood
17) Confidence 0.05 Published 2009 Journal J Occup Med Toxicol Section Body Doc Link PMC2713944 Disease Relevance 0.31 Pain Relevance 0.03
The diagnosis of prolactinoma was made in three of the 16 patients by the absence of PRL response to thyrotropin-releasing factor (TRF) and a dopamine receptor antagonist, metoclopramide, without radiologic evidence of an adenoma.
Positive_regulation (response) of TRF associated with adenoma, prolactinoma, antagonist and dopamine receptor
18) Confidence 0.04 Published 1980 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6766667 Disease Relevance 0.49 Pain Relevance 0.26
Similar inductions of metallothionein, a metal-binding protein, were observed in mice receiving Cd alone or Cd plus V-PYRRO/NO.
Positive_regulation (inductions) of metal-binding protein
19) Confidence 0.04 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.62 Pain Relevance 0.20
Transferrin saturation was elevated in 3.3% and was associated with chronic fatigue.
Positive_regulation (elevated) of Transferrin associated with chronic fatigue syndrome
20) Confidence 0.03 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1797181 Disease Relevance 1.36 Pain Relevance 0.26

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