INT170332

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2011
Negated 7
Speculated 8
Reported most in Body
Documents 477
Total Number 485
Disease Relevance 275.21
Pain Relevance 69.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 69
blood 8
plasma 6
lymphocytes 6
macrophages 5
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6897 100.00 Very High Very High Very High
Inflammation 4080 100.00 Very High Very High Very High
chemokine 855 100.00 Very High Very High Very High
Arthritis 924 99.92 Very High Very High Very High
endometriosis 185 99.88 Very High Very High Very High
Central nervous system 452 99.46 Very High Very High Very High
Multiple sclerosis 299 99.44 Very High Very High Very High
Acupuncture 336 99.40 Very High Very High Very High
metalloproteinase 177 99.38 Very High Very High Very High
Dopamine 42 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4421 100.00 Very High Very High Very High
Cancer 2904 100.00 Very High Very High Very High
Toxicity 827 99.98 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 250 99.98 Very High Very High Very High
Infection 4523 99.96 Very High Very High Very High
Arthritis 681 99.92 Very High Very High Very High
Dengue Hemorrhagic Fever 639 99.92 Very High Very High Very High
Hypersensitivity Pneumonitis 420 99.92 Very High Very High Very High
Hepatitis C Virus Infection 429 99.88 Very High Very High Very High
Endometriosis 224 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the typical cytokine profiles secreted by T helper cells these iNKT cells, which also may express CD4, are capable of producing large amounts of IL-4, IL-13, and IFN-?
Gene_expression (producing) of IFN associated with cytokine
1) Confidence 0.75 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.68 Pain Relevance 0.14
Expression of the pro-inflammatory cytokines IFN-?
Gene_expression (Expression) of IFN associated with inflammation and cytokine
2) Confidence 0.75 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.18 Pain Relevance 0.24
Previous evidence suggests that the concurrent immunization with cHSP60 switches the cytokine production of self HSP60 responding T cells to dominant production of proinflammatory IFN-?
Gene_expression (production) of IFN in T cells associated with immunization and cytokine
3) Confidence 0.75 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 1.12 Pain Relevance 0.36
is not as well established in the pathogenesis of myocardial disease; however, transgenic mice that constitutively express IFN-?
Gene_expression (express) of IFN associated with targeted disruption and cardiomyopathy
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009713 Disease Relevance 0.63 Pain Relevance 0.09
production of IFN-?
Gene_expression (production) of IFN
5) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 1.64 Pain Relevance 0.60
Co-administration of the GM-CSF DNA induced a significant increase in the frequency of mono-functional HA-specific CD8+ T expressing IFN-?
Gene_expression (expressing) of IFN
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.08 Pain Relevance 0.07
The remaining population of HA-specific CD8+ T cells in the lungs of HA DNA vaccinated animals was made up of dual- and triple-cytokine expressing cells (13% and 5%, respectively), with the majority of dual-functional CD8+ T cells expressing IFN-?
Gene_expression (expressing) of IFN in T cells associated with cytokine
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.08 Pain Relevance 0.07
Similar to the CD4+ T cell response, immunization with the HA DNA vaccine alone elicited a HA-specific CD8+ T cell response in the blood that was comprised almost entirely of mono-functional T cells expressing either IFN-?
Gene_expression (expressing) of IFN in T cell associated with immunization
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882341 Disease Relevance 0.10 Pain Relevance 0.07
Studeny's group pioneered to demonstrate that MSC can be integrated into the tumor architecture, which inhibit tumor growth in vivo by local production of an anti-tumor molecule interferon (IFN-?)
Gene_expression (production) of IFN associated with cancer
9) Confidence 0.75 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.86 Pain Relevance 0.05
The production of IFN?
Gene_expression (production) of IFN
10) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0 Pain Relevance 0.04
Whereas there was no significant difference between the two groups in the production of IL-2 and IFN?
Gene_expression (production) of IFN
11) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.11 Pain Relevance 0.11
While NK cells are important in immune surveillance, particularly against viral infections and cancer [22-24], the cells are also likely to play a role in the pathogenesis of inflammatory diseases as they have the ability to produce high levels of the pro-inflammatory cytokines IFN-?
Gene_expression (produce) of IFN in NK cells associated with inflammation, cancer, viral infection, disease and cytokine
12) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.84 Pain Relevance 0.24
Strikingly, we found that the frequencies of H3-, H1-, and NP-specific CD8 cells producing cytokines (IL-2, IFN-?
Gene_expression (producing) of IFN associated with cytokine
13) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.77 Pain Relevance 0.08
Multiparametric flow cytometry assays were performed to determine the relative importance of the subpopulations of influenza-specific CD3+CD4+ and CD3+CD8+ T cells that produce IL-2, IFN-?
Gene_expression (produce) of IFN in T cells associated with influenza virus infection
14) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.81 Pain Relevance 0.04
For both of these vaccines, protection was found to be dependent upon CD4+ T cells producing IFN-?
Gene_expression (producing) of IFN in T cells
15) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.58 Pain Relevance 0
The levels of IL-10, IFN-?
Gene_expression (levels) of IFN
16) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.06 Pain Relevance 0
The production of IFN-?
Gene_expression (production) of IFN
17) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.05 Pain Relevance 0.14
Intradermal injection of Dp significantly increased the expression of IL-4, IL-5, and IL-13 and significantly decreased the expression of IFN-?
Gene_expression (expression) of IFN
18) Confidence 0.75 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.16 Pain Relevance 0.22
Further it has been shown that in many chronic infections in human and experimental animals, CD4+ T cells can produce high levels of both IL-10 and IFN-?
Gene_expression (produce) of IFN in T cells associated with infection
19) Confidence 0.75 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2412883 Disease Relevance 0.69 Pain Relevance 0.25
upregulates the production of proinflammatory cytokines IFN-?
Gene_expression (production) of IFN associated with cytokine
20) Confidence 0.75 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.27 Pain Relevance 0.18

General Comments

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