INT170333

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 68
Total Number 87
Disease Relevance 49.01
Pain Relevance 9.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 5
saliva 3
macrophages 2
microglial cells 2
lymph nodes 1
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 836 100.00 Very High Very High Very High
adenocard 9 100.00 Very High Very High Very High
metalloproteinase 48 99.58 Very High Very High Very High
Multiple sclerosis 118 99.52 Very High Very High Very High
agonist 49 98.82 Very High Very High Very High
Inflammation 723 98.64 Very High Very High Very High
palliative 130 98.32 Very High Very High Very High
rheumatoid arthritis 162 97.12 Very High Very High Very High
Central nervous system 91 95.52 Very High Very High Very High
chemokine 122 94.88 High High
Disease Link Frequency Relevance Heat
Infection 482 100.00 Very High Very High Very High
Influenza Virus Infection 256 100.00 Very High Very High Very High
Skin Cancer 37 100.00 Very High Very High Very High
Weight Gain 7 100.00 Very High Very High Very High
Hepatitis C Virus Infection 194 99.78 Very High Very High Very High
Toxicity 530 99.74 Very High Very High Very High
Cancer 928 99.72 Very High Very High Very High
Hypertension 222 99.62 Very High Very High Very High
Demyelinating Disease 109 99.52 Very High Very High Very High
Hepatocellular Cancer 176 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunizations induced marked specific anti-PfCS102 and anti-sporozoite antibody responses (35/36, at D75, 34/35 at D195) and T cell proliferative responses associated with IFN-?
IFN Binding (associated) of in T cell
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.24 Pain Relevance 0
Also, in view of the recognized lack of IFN-?
IFN Binding (recognized) of
2) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.56 Pain Relevance 0.04
In view of the recognized lack of IFN-?
IFN Binding (recognized) of
3) Confidence 0.47 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.27 Pain Relevance 0
genotype and the severity of renal disease in TSC patients who had TSC2 mutations; they found an association between IFN-?
IFN Binding (association) of associated with renal disease
4) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.82 Pain Relevance 0
However, the association of IFN-?
IFN Binding (association) of
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806829 Disease Relevance 1.37 Pain Relevance 0.13
and matrix metalloproteinases (MMPs) [23], and in conjunction with IL-1 or interferon (IFN)-?
IFN Binding (conjunction) of associated with metalloproteinase
6) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911879 Disease Relevance 0.61 Pain Relevance 0.21
However, upon pulmonary infection with influenza virus, IFN-?
IFN Binding (infection) of associated with influenza virus infection and infection
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.01 Pain Relevance 0.03
If JAK2 sensitivity to CP-690,550 is indeed reduced in cells, our findings suggest that inhibition of the enzyme may not be required to block signaling through receptors for IL-6 and IFN-?
IFN Binding (receptors) of
8) Confidence 0.36 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.16 Pain Relevance 0.15
(i.e., IFN-?
IFN Binding (i.e.) of
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 1.94 Pain Relevance 0.80
A follow up phase I/II study was performed with IDD-3 formulated by pulsing with 3 melanoma cell lines (M44, SKMel28, Colo829), with or without maturation with a bacterial membrane fragment of Klebsiella pneumoniae known as FMKp and interferon gamma (IFN-?)
IFN Binding (pulsing) of associated with skin cancer
10) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2954849 Disease Relevance 0.88 Pain Relevance 0.03
Hence, also patients suffering from allergic asthma displayed mixed T helper cell responses, reflected by the occurrence of TH2 specific IL-13 and of TH1 specific IFN-?
IFN Binding (reflected) of associated with asthma
11) Confidence 0.36 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.66 Pain Relevance 0.12
After activation with interferon-gamma (IFN-?)
IFN Binding (After) of
12) Confidence 0.36 Published 2010 Journal J Transl Med Section Body Doc Link PMC2893125 Disease Relevance 0.83 Pain Relevance 0.10
By contrast many cytokines (including, for example, IFN-?)
IFN Binding (example) of associated with cytokine
13) Confidence 0.36 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.38 Pain Relevance 0.23
In addition, nebulized rIFN-?
IFN Binding (nebulized) of
14) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.71 Pain Relevance 0.12
Estimation of adenosine deaminase (ADA) and IFN-?
IFN Binding (Estimation) of associated with adenocard
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856669 Disease Relevance 1.04 Pain Relevance 0.09
These findings indicate that innate immune cells more contribute to IFN-?
IFN Binding (contribute) of in immune cells
16) Confidence 0.36 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 1.14 Pain Relevance 0
Briefly, three bead populations with distinct fluorescence intensities and coated with capture antibodies specific for IL-2, IFN-?
IFN Binding (specific) of
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811739 Disease Relevance 0.12 Pain Relevance 0.11
Human patients receiving immunotherapy with IFN-?
IFN Binding (receiving) of
18) Confidence 0.36 Published 2008 Journal Biological Psychiatry Section Body Doc Link PMC2885493 Disease Relevance 1.41 Pain Relevance 0.83
Additional analysis of CD8+ cell subsets were determined by staining with anti-IFN-?
IFN Spec (determined) Binding (staining) of
19) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.07 Pain Relevance 0.03
We performed a randomized, controlled clinical trial of directly observed therapy (DOTS) versus DOTS supplemented with nebulized or subcutaneously administered rIFN-?
IFN Binding (supplemented) of
20) Confidence 0.36 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2737621 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

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