INT170335

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2011
Negated 0
Speculated 6
Reported most in Body
Documents 176
Total Number 183
Disease Relevance 91.62
Pain Relevance 15.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
macrophages 4
plasma 4
fibroblasts 4
spinal cord 3
stem cells 3
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1516 100.00 Very High Very High Very High
antagonist 569 100.00 Very High Very High Very High
rheumatoid arthritis 330 100.00 Very High Very High Very High
metalloproteinase 201 100.00 Very High Very High Very High
corticosteroid 42 99.92 Very High Very High Very High
cytokine 1369 99.88 Very High Very High Very High
Spinal cord 378 99.84 Very High Very High Very High
substance P 362 99.84 Very High Very High Very High
opioid receptor 226 99.84 Very High Very High Very High
imagery 410 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3500 100.00 Very High Very High Very High
INFLAMMATION 1649 100.00 Very High Very High Very High
Infection 1060 100.00 Very High Very High Very High
Sprains And Strains 1024 100.00 Very High Very High Very High
Toxicity 924 100.00 Very High Very High Very High
Rheumatoid Arthritis 588 100.00 Very High Very High Very High
Hepatitis C Virus Infection 567 100.00 Very High Very High Very High
Prostate Cancer 189 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 44 100.00 Very High Very High Very High
Reprotox - General 1 165 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tablets disintegrated in vitro and in vivo within 4 to 7 s and 6 to 19 s, respectively.
Gene_expression (disintegrated) of in vitro
1) Confidence 0.54 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Abstract Doc Link PMC2883231 Disease Relevance 0 Pain Relevance 0
m deep microconduits in vivo yielded blood sample volumes of several ?
Gene_expression (yielded) of in vivo in blood
2) Confidence 0.42 Published 2004 Journal BMC Med Section Abstract Doc Link PMC400509 Disease Relevance 0.05 Pain Relevance 0.13
The results for glucose and lactate in vitro extraction are shown in Figure 3.
Gene_expression (extraction) of in vitro
3) Confidence 0.36 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2527667 Disease Relevance 0 Pain Relevance 0
Animal and in vitro studies
Gene_expression (studies) of in vitro
4) Confidence 0.18 Published 2010 Journal Health Res Policy Syst Section Body Doc Link PMC2825185 Disease Relevance 0.16 Pain Relevance 0
Consequently, dedifferentiated chondrocytes produce fibrocartilage in vivo, with an extracellular matrix of inferior biomechanical properties due to higher collagen (especially type I) content and less proteoglycans compared with native hyaline cartilage [36].
Gene_expression (produce) of in vivo in inferior associated with osteoarthritis
5) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.46 Pain Relevance 0.15
All tetraploids, either maintained in vitro for eight cycles of culture or grown in the glasshouse for 6 months, were stable with no sign of ploidy reversion or chimerism.


Gene_expression (maintained) of in vitro associated with tetraploidy
6) Confidence 0.12 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881646 Disease Relevance 0.40 Pain Relevance 0
PK data are lacking in patients on continuous venovenous heamofiltration (CVVH) but it has been shown in vitro that OC crosses the haemofilter freely and has a sieving coefficient (Sieving coefficient?
Gene_expression (shown) of in vitro
7) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.63 Pain Relevance 0.07
In vitro, mean IC50 OC values against H5N1 vary by viral clade and methodology, ranging from ?
Gene_expression (vary) of In vitro
8) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.48 Pain Relevance 0
Substance P has been the target of an in vitro selection earlier, resulting in an RNA aptamer with a dissociation constant of 190 nM (16).
Gene_expression (selection) of in vitro associated with substance p
9) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0.25 Pain Relevance 0.44
For in vitro selection, d-substance P with C-terminally attached biotin was used.
Gene_expression (selection) of in vitro associated with substance p
10) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.24
During automated in vitro selection, most liquid handling manipulations were performed in 96-well plates with removable lids; partitioning of unbound from bound RNA species was carried out in Mobicol columns (MoBiTec AG, Göttingen, Germany); for automated transcript purification, Microcon ultrafiltration units were employed (Millipore, Eschborn, Germany).
Gene_expression (selection) of in vitro
11) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.04
Process of automated in vitro selection
Gene_expression (selection) of in vitro
12) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.04
In vitro cell assays
Gene_expression (assays) of In vitro
13) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.38
Therefore, the system specifications of the robotic workstation for automated in vitro selection were set to be as close as possible to the manual procedures.
Gene_expression (selection) of in vitro
14) Confidence 0.10 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC552970 Disease Relevance 0 Pain Relevance 0.12
In vitro studies suggest that IL-6 act as a negative regulator of chondrocyte proliferation and articular cartilage metabolism [24] and that IL-8 possibly act as a modulator of both IL-6 and TNF-?
Gene_expression (studies) of In vitro in articular cartilage
15) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945016 Disease Relevance 0.69 Pain Relevance 0.40
When the test compound produces severe toxicity in vitro and is anticipated to reach therapeutic plasma concentrations that are greater than or equal to the TC50 value the probability of in vivo toxicity is high.
Gene_expression (produces) of in vitro in plasma associated with toxicity
16) Confidence 0.08 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.90 Pain Relevance 0.15
In vitro cyclooxygenase gene expression in normal and HP fibroblasts exposed to pyridoxal phosphate (PLP) and calcium pyrophosphate (CPPD)
Gene_expression (expression) of In vitro in fibroblasts associated with phosphate metabolism disorders
17) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.37 Pain Relevance 0
In vitro, CTPs can be assayed and cultured under specific biochemical conditions that promote osteoblastic differentiation (Majors, Boehm et al 1997; Muschler, Boehm et al 1997).
Gene_expression (assayed) of In vitro associated with osteoporosis
18) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676655 Disease Relevance 0.25 Pain Relevance 0.05
We and others have widely explored these mechanisms in vitro [61–63].
Gene_expression (explored) of in vitro
19) Confidence 0.07 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.48 Pain Relevance 0.20
This compound did produce cytotoxicity in vitro with a predicted Ctox value of 15 µM.
Gene_expression (produce) of in vitro
20) Confidence 0.07 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.79 Pain Relevance 0.09

General Comments

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