INT170343

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.77
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
visceral 2
retina 2
tectum 2
head 2
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 269 100.00 Very High Very High Very High
Glutamate receptor 104 100.00 Very High Very High Very High
addiction 3 100.00 Very High Very High Very High
Visceral pain 1 99.40 Very High Very High Very High
antagonist 20 97.88 Very High Very High Very High
Pyramidal cell 98 97.48 Very High Very High Very High
medulla 5 95.56 Very High Very High Very High
Central grey 77 94.68 High High
Hippocampus 30 91.00 High High
IPN 22 90.88 High High
Disease Link Frequency Relevance Heat
Injury 22 99.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 99.40 Very High Very High Very High
Nociception 35 94.84 High High
Urological Neuroanatomy 78 94.68 High High
Inflammatory Pain 22 90.88 High High
Pain 30 83.32 Quite High
Depression 73 80.24 Quite High
Targeted Disruption 24 77.20 Quite High
Sprains And Strains 8 76.20 Quite High
INFLAMMATION 33 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The demonstration that GluR1 expression is increased in the retina of the rdta mouse where a rod photoreceptor-mediated visual input is missing is consistent with a previous report in which the level of GluR1 is increased in the deafferented tectum [64,65].
Positive_regulation (increased) of Gene_expression (expression) of GluR1 in tectum
1) Confidence 0.61 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.07
-32P-ATP labeling of GluR1 by this procedure was greater in the retinae of control mice than in the retina of the rdta mice (Figure 4A), whereas the expression of GluR1 was increased in the rdta mice relative to their littermate controls (Figure 4B).
Positive_regulation (increased) of Gene_expression (expression) of GluR1 in retina
2) Confidence 0.44 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
In the present study, an increased synaptic expression of the NMDA receptors and GluR1 subunits is associated with changes in CaMKII.
Positive_regulation (increased) of Gene_expression (expression) of GluR1 associated with nmda receptor
3) Confidence 0.44 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.08
2 channel activities, although lurcher mutation transformed GluR?
Positive_regulation (transformed) of Gene_expression (transformed) of GluR associated with glutamate receptor
4) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.23 Pain Relevance 0.73
For example, noxious stimuli can change the expression ratio of synaptic AMPA receptor subunits GluR1 to GluR2 in a visceral pain model [24].
Positive_regulation (change) of Gene_expression (expression) of GluR1 in visceral associated with visceral pain
5) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.67 Pain Relevance 0.54
1 mRNA were co-localized with those of the GAD67 mRNA, suggesting that expression of the GluR?
Positive_regulation (suggesting) of Gene_expression (expression) of GluR
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.23
It is unknown why the GluR?
Positive_regulation (why) of Gene_expression (unknown) of GluR
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.08 Pain Relevance 0.10
Similar to NR2B, AMPA receptor GluR1 subunit expression was also increased after injury (189.4% ± 26.5% of saline, n = 6, p < 0.01; Fig. 1).
Positive_regulation (increased) of Gene_expression (expression) of GluR1 associated with injury
8) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.70 Pain Relevance 0.94
Increased cell surface GluR1 expression correlated with changes in synaptic transmission that shared the same NO–cGMP–PKG-dependent properties.
Positive_regulation (Increased) of Gene_expression (expression) of GluR1
9) Confidence 0.14 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.11
Furthermore, in a separate set of experiments, the glutamate receptor dependence of the spine head calcium transient generated by this stimulus (early and late ?
Positive_regulation (generated) of Gene_expression (dependence) of glutamate receptor in head associated with addiction and glutamate receptor
10) Confidence 0.03 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2734993 Disease Relevance 0 Pain Relevance 0.31

General Comments

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