INT170345

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.88
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
ganglion cells 3
hearts 2
amacrine cells 1
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 40 100.00 Very High Very High Very High
antagonist 51 99.48 Very High Very High Very High
Nerve growth factor 14 96.16 Very High Very High Very High
nMDA receptor 54 94.68 High High
Calcitonin gene-related peptide 20 86.24 High High
agonist 18 77.96 Quite High
adenocard 5 67.76 Quite High
bradykinin 7 66.88 Quite High
noradrenaline 1 65.92 Quite High
Opioid 1 64.48 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 100.00 Very High Very High Very High
Cv Unclassified Under Development 68 98.56 Very High Very High Very High
Parkinson's Disease 116 91.56 High High
Reperfusion Injury 30 82.36 Quite High
Targeted Disruption 21 77.28 Quite High
Nociception 21 50.00 Quite Low
Stress 19 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Adenocarcinoma 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts
1) Confidence 0.23 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
Fig. 8 examines the effect of exposure to neurotrophic factors on expression of functional PAR1/4 receptors, measured from PKC?
Negative_regulation (receptors) of Localization (measured) of PKC
2) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.45
We have previously reported that retinal CaMKII mRNA, protein and enzyme activity (localized in the somas of amacrine cells and ganglion cells and in the inner plexifom layer) but not PKC?
Negative_regulation (retinal) of in amacrine cells Neg (not) Localization (localized) of PKC in ganglion cells associated with ganglion cysts
3) Confidence 0.08 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.19 Pain Relevance 0.16
translocation to the mitochondria of IP hearts (Fig. 1A) whilst others have observed that PKC translocation to the particulate fraction following IP is transient and lost during progressive brief cycles of ischaemia and reperfusion [116].
Negative_regulation (lost) of Localization (translocation) of PKC in hearts associated with kinase c and cv unclassified under development
4) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.51 Pain Relevance 0.79
in the presence/absence of the FP receptor antagonist (AL8810), EP2 receptor antagonist (AH6809), EP4 receptor antagonist (ONOAE2227), or chemical inhibitors of PLC (U73122), PKA (4C3MQ), PKC (GF109203x), EGFR kinase (AG1478) or ERK1/2 kinase (PD98059).
Negative_regulation (inhibitors) of Localization (kinase) of PKC associated with antagonist
5) Confidence 0.04 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.32

General Comments

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