INT170346

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 7.69
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
macrophages 4
lungs 3
brain 1
insula 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 96.40 Very High Very High Very High
insula 3 96.16 Very High Very High Very High
imagery 45 84.64 Quite High
positron emission tomography 57 62.20 Quite High
nMDA receptor 81 61.80 Quite High
cINOD 3 61.20 Quite High
Glutamate receptor 21 50.00 Quite Low
Serotonin 9 50.00 Quite Low
Inflammation 14 46.28 Quite Low
anesthesia 7 21.48 Low Low
Disease Link Frequency Relevance Heat
Disease 377 99.04 Very High Very High Very High
Stress 8 98.60 Very High Very High Very High
Congenital Anomalies 38 97.86 Very High Very High Very High
Targeted Disruption 25 97.42 Very High Very High Very High
INFLAMMATION 21 96.04 Very High Very High Very High
Atherosclerosis 48 95.72 Very High Very High Very High
Disorder Of Lipid Metabolism 31 93.92 High High
Atherosclerotic Plaque 8 92.72 High High
Nicotine Addiction 120 88.64 High High
Coronary Artery Disease 168 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zhang et al. disrupted NPC1 expression in macrophages of Ldlr-/- mice and demonstrated that absence of NPC1 expression was proatherogenic in vivo[21].
Gene_expression (expression) of NPC1 in macrophages
1) Confidence 0.78 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.38 Pain Relevance 0
Normand Podechard[26] recently found that human macrophages exposed to environmental aryl hydrocarbons and Aryl hydrocarbons (AHs) was found to decrease expression of NPC1 at both mRNA and protein levels.
Gene_expression (expression) of NPC1 in macrophages
2) Confidence 0.78 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.43 Pain Relevance 0
Zhang et al. disrupted NPC1 expression in macrophages of Ldlr-/- mice and demonstrated that absence of NPC1 expression was proatherogenic in vivo[21].
Gene_expression (expression) of NPC1 in macrophages
3) Confidence 0.78 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.40 Pain Relevance 0
The NPC1 and NPC2 proteins
Gene_expression (proteins) of NPC1
4) Confidence 0.66 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.48 Pain Relevance 0
Mutations in NPC1 and NPC2 give rise to severe abnormalities in the intracellular transport of lipid, notably cholesterol, glycosphingolipids and sphingosine.8–12 The NPC1 or NPC2 gene products normally function cooperatively in intracellular lipid transport,8,13,14 and so impaired function leads to the accumulation of lipids in the late-endosomal and lysosomal intracellular compartments, resulting in the build-up of excess lipids in various tissues.
Gene_expression (products) of NPC1 associated with congenital anomalies
5) Confidence 0.63 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.54 Pain Relevance 0
In TCDD- and BP-exposed macrophages the NPC1 expression decreased at both mRNA and protein levels.
Gene_expression (expression) of NPC1 in macrophages
6) Confidence 0.60 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.01 Pain Relevance 0.05
Support groups for Lysosomal Diseases or Inborn Errors of Metabolism with a specific Niemann-Pick subgroup:
Gene_expression (subgroup) of Niemann-Pick associated with disease
7) Confidence 0.58 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.58 Pain Relevance 0.03
Various transgenic mice have been generated, such as mice over expressing Rab9, a protein involved in intracellular trafficking [131-133], or mice expressing NPC1 only in one particular brain cell type [134].
Gene_expression (expressing) of NPC1 in brain associated with targeted disruption
8) Confidence 0.52 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.32 Pain Relevance 0.10
Evaluations of the luciferase expression for D-SPM were also performed at 2 days post-treatment by Hosseinkhani et al. [28], which exhibited optimum transfection efficiency.
Gene_expression (expression) of D-SPM
9) Confidence 0.27 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
The SPM proteins were first incubated with 50 ?
Gene_expression (proteins) of SPM
10) Confidence 0.26 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Different amounts of the crude SPM protein, 2, 4, 6, 8, and 12 ?
Gene_expression (amounts) of SPM protein
11) Confidence 0.26 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.05 Pain Relevance 0
To test this notion, the SPM proteins isolated from the retinae of the rdta and their littermate controls mice were back-phosphorylated in the presence of Ca2+/calmodulin and ?
Gene_expression (proteins) of SPM
12) Confidence 0.26 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.03
For the cell culture study, dextran-spermine (D-SPM) and pDNA complexes were prepared at various D-SPM/pDNA weight-mixing ratios of 8 to 18 (?
Gene_expression (weight) of D-SPM/pDNA
13) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.08 Pain Relevance 0
In addition, the evaluation on the safety profiles of D-SPM as a gene carrier to the lung, which has not been performed in this study, should be conducted to complement the reporter gene expression results.



Gene_expression (expression) of D-SPM in lung
14) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
As the main concern for the in vitro study was also to verify the ability of D-SPM to deliver the gene into cell, COS-7 cells ware chosen for this experiment as this cell line has been shown to be effectively transfected by D-SPM previously in [30].
Gene_expression (transfected) of D-SPM
15) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
For the cell culture study, dextran-spermine (D-SPM) and pDNA complexes were prepared at various D-SPM/pDNA weight-mixing ratios of 8 to 18 (?
Gene_expression (weight) of D-SPM
16) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.08 Pain Relevance 0
An older version of the SPM software (SPM99) was used for exploratory image analysis.
Gene_expression (software) of SPM
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.06 Pain Relevance 0.07
An older version of the SPM software (SPM99) was used for exploratory image analysis.
Gene_expression (software) of SPM99
18) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.06 Pain Relevance 0.07
In addition, the SPM analysis identified in the C-LHPA group areas of increased normalized K* in limbic areas, including the insula (max voxels?
Gene_expression (analysis) of SPM in insula associated with insula
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.21 Pain Relevance 0.13
Here, we extended the observations by determining the optimal conditions for gene expression of D-SPM/plasmid DNA (D-SPM/pDNA) in cell lines and in the lungs of BALB/c mice via instillation delivery.
Gene_expression (expression) of D-SPM in lungs
20) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0

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