INT170347

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.33
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 64 100.00 Very High Very High Very High
depression 65 87.28 High High
Pyramidal cell 48 77.12 Quite High
nMDA receptor 103 72.88 Quite High
Thalamus 2 58.72 Quite High
Hippocampus 10 58.20 Quite High
long-term potentiation 29 31.04 Quite Low
Glutamate 12 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 31 94.00 High High
Depression 65 87.28 High High
Autism 3 50.00 Quite Low
Congenital Anomalies 7 28.64 Quite Low
Syndrome 15 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation of GluR1 was performed after the back phosphorylation of retinal SPM proteins (described above) using an immunoprecipitation kit (Protein G; Boehringer Mannheim, Indianapolis, IN).
Positive_regulation (performed) of Localization (Immunoprecipitation) of GluR1
1) Confidence 0.44 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
In our studies, haploinsufficiency of Shank3 in vivo leads to reduced levels of AMPA receptors and GluR1-positive puncta, results which are consistent with such studies in vitro.
Positive_regulation (leads) of Localization (levels) of GluR1
2) Confidence 0.31 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0
One possible signaling mechanism through GluR?
Spec (possible) Positive_regulation (through) of Localization (mechanism) of GluR associated with glutamate receptor
3) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.23 Pain Relevance 0.72
1 mRNA can be ascribed to the insertion of cre into one allele of the GluR?
Positive_regulation (ascribed) of Localization (allele) of GluR associated with glutamate receptor
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.09 Pain Relevance 0.50

General Comments

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