INT170348

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.29
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
retina 2
hippocampus 2
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 77 99.92 Very High Very High Very High
Hippocampus 38 99.72 Very High Very High Very High
nMDA receptor 113 99.24 Very High Very High Very High
Central nervous system 24 98.76 Very High Very High Very High
IPN 13 95.60 Very High Very High Very High
Glutamate 18 93.12 High High
Anterior cingulate cortex 90 90.56 High High
antagonist 50 89.84 High High
tail-flick 21 86.76 High High
Dorsal horn 25 85.92 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 105 99.92 Very High Very High Very High
Inflammatory Pain 13 95.60 Very High Very High Very High
Targeted Disruption 108 91.32 High High
Cognitive Disorder 13 88.64 High High
Aging 31 84.40 Quite High
Neuropathic Pain 10 82.72 Quite High
Pain 75 82.20 Quite High
INFLAMMATION 28 76.28 Quite High
Substance Withdrawal Syndrome 9 67.28 Quite High
Drug Dependence 31 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The down regulation of NR2B expression throughout development is marked by a concomitant change in NMDA receptor function [13].
Regulation (regulation) of Gene_expression (expression) of NR2B associated with nmda receptor
1) Confidence 0.60 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.44 Pain Relevance 1.64
Changes in NR2B protein expression in homogenates from the hippocampus also show a correlation with spatial reference memory in aged Fisher 344 rats [78].
Regulation (Changes) of Gene_expression (expression) of NR2B in hippocampus associated with hippocampus
2) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.41 Pain Relevance 0.46
NR1 expression and NR2A/B composition are altered in the rdta retina
Regulation (altered) of Gene_expression (composition) of NR2A/B in retina
3) Confidence 0.36 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.05
In contrast, there is no difference of NR2B component by 3 ?
Neg (no) Regulation (difference) of Gene_expression (component) of NR2B
4) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.12
M) did not affect NR2B component, whereas lower concentration of NVP (0.1 ?
Neg (not) Regulation (affect) of Gene_expression (component) of NR2B
5) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.15
In present investigation, we demonstrate for the first time that changes in NMDARs expression in the PAG is selective for NR2B subunits, not NR2A ones.
Neg (not) Regulation (selective) of Gene_expression (subunits) of NR2B associated with central grey
6) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.01 Pain Relevance 1.22
It appears that the effect of PSD-93 deletion on NR2A and NR2B synaptic expression may be tissue specific in the CNS, although the detailed mechanisms underlying these events are still unclear.
Regulation (effect) of Gene_expression (expression) of NR2B associated with central nervous system
7) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.30 Pain Relevance 0.50
Effect of PSD-93 deletion on the expression of NR2A and NR2B in total soluble and synaptosomal membrane fractions
Regulation (Effect) of Gene_expression (expression) of NR2B
8) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.06 Pain Relevance 0.11

General Comments

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