INT170350

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.36
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
spines 1
synapse 1
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 132 100.00 Very High Very High Very High
depression 132 95.96 Very High Very High Very High
Hyperalgesia 4 92.68 High High
IPN 9 92.12 High High
Hippocampus 27 85.92 High High
Pain 10 85.20 High High
Inflammation 11 82.80 Quite High
Pyramidal cell 96 75.44 Quite High
spinal dorsal horn 7 73.92 Quite High
nMDA receptor 183 71.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 26 98.88 Very High Very High Very High
Depression 132 95.96 Very High Very High Very High
Convulsion 62 94.32 High High
Hyperalgesia 5 92.68 High High
Inflammatory Pain 9 92.12 High High
INFLAMMATION 11 82.80 Quite High
Congenital Anomalies 14 67.28 Quite High
Autism 6 50.00 Quite Low
Injury 2 49.36 Quite Low
Dyspepsia 1 40.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation of GluR1 was performed after the back phosphorylation of retinal SPM proteins (described above) using an immunoprecipitation kit (Protein G; Boehringer Mannheim, Indianapolis, IN).
Localization (Immunoprecipitation) of GluR1
1) Confidence 0.65 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
In our studies, haploinsufficiency of Shank3 in vivo leads to reduced levels of AMPA receptors and GluR1-positive puncta, results which are consistent with such studies in vitro.
Localization (levels) of GluR1
2) Confidence 0.46 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0
Transfection of Shank3 into aspiny cerebellar granule cells has been shown to induce an increase in the AMPA component of mEPSCs [19], and Shank3 is colocalized with GluR1-containing AMPA receptor in typical spines [53].
Localization (colocalized) of GluR1 in spines
3) Confidence 0.46 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0
It suggests a significant membrane translocation of GluR1-containing AMPA receptors to a spinal nociceptive synapse during acute noxious stimulation [27].
Localization (translocation) of GluR1-containing in synapse associated with nociception
4) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.51 Pain Relevance 0.63
One possible signaling mechanism through GluR?
Localization (mechanism) of GluR associated with glutamate receptor
5) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.23 Pain Relevance 0.72
However, Delphilin ablation appeared to exert little effect on the amount and localization of GluR?
Localization (localization) of GluR associated with glutamate receptor
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.83 Pain Relevance 0.51
1 mRNA can be ascribed to the insertion of cre into one allele of the GluR?
Localization (allele) of GluR associated with glutamate receptor
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.09 Pain Relevance 0.50
1+/flox mice, indicating that the insertion of the Cre gene in one allele of GluR?
Localization (allele) of GluR
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.69 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox