INT170351

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.67
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
neurons 6
hippocampus 6
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 256 100.00 Very High Very High Very High
addiction 9 100.00 Very High Very High Very High
long-term potentiation 371 99.96 Very High Very High Very High
Glutamate 48 99.84 Very High Very High Very High
nMDA receptor 103 97.24 Very High Very High Very High
Endocannabinoid 2 96.72 Very High Very High Very High
agonist 20 95.52 Very High Very High Very High
Pain 45 94.60 High High
medulla 1 93.96 High High
Spinal sensitization 7 92.88 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 324 99.48 Very High Very High Very High
Bone Cancer 41 99.48 Very High Very High Very High
Pain 48 94.60 High High
Convulsion 28 88.08 High High
Cancer 82 78.96 Quite High
Depression 141 77.88 Quite High
Anxiety Disorder 203 75.64 Quite High
Ganglion Cysts 31 61.20 Quite High
Sprains And Strains 4 60.24 Quite High
Necrosis 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, a number of different experiences (e.g. learning, drug exposure, sensory deprivation) increase the expression of GluR2-lacking Ca2+-permeable AMPARs [9], [51], [52], [53], [54].
Positive_regulation (increase) of Gene_expression (expression) of GluR2
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.26 Pain Relevance 0.12
First, the expression of AMPA receptor may be upregulated in neurabin KO mice.
Positive_regulation (upregulated) of Gene_expression (expression) of AMPA associated with targeted disruption
2) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.12 Pain Relevance 0.27
Our results demonstrate that deletion of GluR2 in the CA1 region of the hippocampus produces AMPAR-mediated plasticity that impairs learning and memory.
Positive_regulation (produces) of Gene_expression (deletion) of GluR2 in hippocampus associated with hippocampus
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.31 Pain Relevance 0.15
Consequently, a potential mechanism for NMDAR-independent learning and plasticity in the hippocampus is the expression and activation of GluR2-lacking (Ca2+-permeable) AMPARs.
Positive_regulation (activation) of Gene_expression (expression) of GluR2 in hippocampus associated with hippocampus
4) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.34
We showed that deletion of the GluR2 subunit in the CA1 region of the hippocampus makes LTP induction possible in the absence of NMDAR activation.
Spec (possible) Positive_regulation (makes) of Gene_expression (deletion) of GluR2 in hippocampus associated with long-term potentiation and hippocampus
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.26
It has been showed that an over-expression of Stargazin increases the number of extra-synaptic AMPA receptors without affecting AMPA receptor-mediated synaptic transmission.
Positive_regulation (increases) of Gene_expression (receptors) of AMPA
6) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.13
The enhanced EPSCs are not due to the possible change in the voltage dependence of AMPA receptor-mediated currents, since the I-V relationship of AMPA receptor-mediated EPSCs between neurabin KO mice (n?
Spec (possible) Positive_regulation (dependence) of Gene_expression (currents) of AMPA associated with targeted disruption and addiction
7) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.71 Pain Relevance 0.18
Moreover, no difference was found for total GluR2&3 expression between two groups (n?
Positive_regulation (found) of Gene_expression (expression) of GluR2
8) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.43 Pain Relevance 0.07
In particular, the overexpression of GluR2 induces the development and growth of dendritic spines in cultured hippocampal neurons [48], [49].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GluR2 in neurons
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
However, it is of note that AMPA receptor endocytosis is not required for LTD in all cortical layers.
Neg (not) Positive_regulation (required) of Gene_expression (endocytosis) of AMPA receptor
10) Confidence 0.23 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.05 Pain Relevance 0.24
In contrast to previous observations that the AMPA receptor expression is relatively constant in glutamate sensitive neurons [26], recent studies have shown that the expression of AMPA receptor subunits, especially GluR1, the major functional subunit of the AMPA receptor [11] is regulated developmentally at regional, cellular, and synaptic levels [27,28,29,30].
Positive_regulation (constant) of Gene_expression (expression) of AMPA in neurons associated with glutamate
11) Confidence 0.07 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.30
induces enhancement of synaptic efficacy by increasing surface AMPA receptor expression in hippocampal neurons [42].
Positive_regulation (increasing) of Gene_expression (expression) of AMPA in neurons
12) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 0.16 Pain Relevance 0.54
Using dissociated hippocampal cells to visualize AMPA receptor trafficking, the latter authors observed increased synaptic surface expression of GluR2 subunits of the AMPA receptor within minutes of exposure to corticosterone, BSA-conjugated corticosterone or aldosterone (the prototypic nMR agonist).
Positive_regulation (increased) of Gene_expression (expression) of AMPA receptor associated with agonist
13) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.06 Pain Relevance 0.12
These results suggest that the increased responses in the bone cancer model mice may be due to increased expression levels of the AMPA receptors with similar kinetics.
Positive_regulation (increased) of Gene_expression (expression) of AMPA associated with bone cancer
14) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.51 Pain Relevance 0.51
We found that the application of an AC activator (FSK) mimicked the enhancement of AMPA currents produced by PACAP.
Positive_regulation (enhancement) of Gene_expression (produced) of AMPA
15) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.03

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