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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.72
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1, Grin2a) plasma membrane (Grin1, Grin2a) locomotion (Grin2a)
enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
plasma 1
neurons 1
Grin1 (Mus musculus)
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 116 99.76 Very High Very High Very High
Anterior cingulate cortex 38 93.08 High High
Lasting pain 11 93.04 High High
amygdala 1 91.68 High High
Hippocampus 19 91.28 High High
Rostral ventromedial medulla 14 88.88 High High
Central grey 78 88.72 High High
Pain 20 88.28 High High
gABA 2 86.68 High High
Glutamate 24 86.32 High High
Disease Link Frequency Relevance Heat
Injury 19 94.40 High High
Pain 30 93.04 High High
Urological Neuroanatomy 79 88.72 High High
INFLAMMATION 27 85.04 High High
Nociception 13 80.44 Quite High
Depression 32 72.48 Quite High
Neuropathic Pain 4 59.52 Quite High
Ganglion Cysts 3 57.76 Quite High
Nervous System Injury 3 55.08 Quite High
Anxiety Disorder 26 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The formation of functional NMDA receptors requires a combination of NR1 and at least one NR2 subunit [2].
NR1 Binding (combination) of NR2 associated with nmda receptor
1) Confidence 0.23 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0 Pain Relevance 0.57
Because isolated NR2 subunits do not traffic to the plasma membrane unless they are in a complex with an NR1 subunit (Dunah et al., 1998; Cull-Candy and Leszkiewicz, 2004), the NR2D receptors expressed in the plasma membrane of WT mouse neurons are likely part of fully assembled NMDAR complexes.
NR1 Binding (complex) of NR2 in plasma
2) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
For example, the kinetics of the NMDA receptors are regulated by the combinatorial associations of the NR1 and NR2 subunits [44].
NR1 Binding (associations) of NR2 associated with nmda receptor
3) Confidence 0.21 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.25
Functional NMDA receptors in the hippocampal CA1 neurons contain mainly heterogenic combinations of the NR1 with NR2A or NR2B subunits [46].
NR1 Binding (combinations) of NR2A in neurons associated with nmda receptor
4) Confidence 0.16 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.31 Pain Relevance 0.71
The formation of functional NMDARs requires a combination of NR1, an essential channel-forming subunit, and at least one NR2 subunit.
NR1 Binding (combination) of NR2
5) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.35 Pain Relevance 1.23

General Comments

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