INT170385

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 4.95
Pain Relevance 6.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Clock) DNA binding (Clock) cytoplasm (Clock)
signal transducer activity (Clock) signal transduction (Clock) chromosome (Clock)
Anatomy Link Frequency
liver 4
retina 2
photoreceptors 1
amacrine cells 1
internal 1
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 96 100.00 Very High Very High Very High
Dopamine 695 99.98 Very High Very High Very High
gABA 1162 99.88 Very High Very High Very High
GABAergic 117 98.74 Very High Very High Very High
Nucleus accumbens 10 98.32 Very High Very High Very High
Cholecystokinin 16 98.04 Very High Very High Very High
Limbic system 5 96.28 Very High Very High Very High
addiction 48 95.12 Very High Very High Very High
depression 84 92.64 High High
withdrawal 77 89.72 High High
Disease Link Frequency Relevance Heat
Metabolic Syndrome 51 99.68 Very High Very High Very High
Drug Dependence 9 95.12 Very High Very High Very High
Depression 93 93.76 High High
Breast Cancer 17 93.44 High High
Diabetes Mellitus 13 91.72 High High
Ganglion Cysts 240 91.44 High High
Hypertension 18 91.04 High High
Reprotox - General 1 3 90.96 High High
Affective Disorder 27 90.88 High High
Dyslipidemia /

Combined Dyslipidemia

6 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NcoR1 and Hdac3 are critical for the regulation of clock genes and energy metabolism homeostasis.
Regulation (regulation) of clock
1) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.17 Pain Relevance 0
PPARs in peripheral tissues exhibit a strong interplay with the central circadian clock components, serving both as affecters and effecters of the clock system.
Regulation (affecters) of clock
2) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.22 Pain Relevance 0
Effect of Gender on the Biological Clock and PPARs Expression
Regulation (Effect) of Clock
3) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.52 Pain Relevance 0
In contrast, dopamine is a key regulator of the endogenous retinal clock mechanism.
Regulation (regulator) of clock associated with dopamine
4) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.41
However, these neurochemical assays of clock output have left open questions of whether dopamine or melatonin modulates the retinal molecular clock mechanism itself and what roles they may play in the organization of retinal clockworks.
Spec (whether) Regulation (modulates) of clock associated with dopamine
5) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.06 Pain Relevance 0.36
The circuitry of mammalian retinal dopaminergic amacrine cells [72,73], the molecular action of dopamine on retinal clock genes [68], and our direct demonstration of dopamine effects on clock phase and light resetting of retinal clock phase, all indicate that dopamine transmission likely mediates light entrainment of the inner retinal mammalian circadian clock through its action on Per gene levels and rhythms.
Regulation (effects) of clock in amacrine cells associated with dopamine
6) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.63
To further test whether GABAergic suppression of PER2::LUC luminescence rhythms results from an effect on the core function of the retinal clock, we tested whether prolonged application of GABA can halt the molecular oscillation of the retinal clock.
Spec (whether) Regulation (effect) of clock associated with gaba and gabaergic
7) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.45
Although a diet of 100% glucose has been reported to cause FAA in the rat [18], our present results suggest that 100% glucose does not affect phase advance of the liver clock.
Neg (not) Regulation (affect) of clock in liver
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0 Pain Relevance 0
Clock resetting by the down regulation of Per1 and Per2 has been observed in Rat-1 fibroblasts treated with glucose [17].
Regulation (resetting) of Clock in fibroblasts
9) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0.09 Pain Relevance 0.11
At present, we do not know the role of such gut hormones on phase shift of the liver clock; however, some studies have suggested a role of CCK in circadian systems [26], [27].
Regulation (role) of clock in liver associated with cholecystokinin
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0 Pain Relevance 0.20
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
Regulation (alters) of CLOCK
11) Confidence 0.28 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0
Our previous research showed that conditioned place preference with morphine treatment was altered in mice lacking the Period-1 (mPer1) circadian clock gene.
Regulation (altered) of clock associated with morphine
12) Confidence 0.28 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.25 Pain Relevance 0.56
, such as the insulin signaling in liver [15], regulate the circadian clock by altering the phosphorylation state and the stability of BMAL1.
Regulation (regulate) of clock in liver
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.25 Pain Relevance 0.08
Control of clock protein stability is a key regulatory step to insure the tightness of circadian rhythms [22], [23].
Regulation (Control) of clock
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
Moreover, lithium-induced period lengthening has also been demonstrated on the pacemaking properties of single cells, suggesting a direct modulation of the clock mechanism [15].
Regulation (modulation) of clock
15) Confidence 0.27 Published 2007 Journal J Circadian Rhythms Section Body Doc Link PMC1803776 Disease Relevance 0.17 Pain Relevance 0.10
The period gene is rhythmically expressed in multiple tissues as well as in the central "clock" controlling behavior in both Drosophila [33] and mouse [7,8,10,11,12].
Regulation (controlling) of clock
16) Confidence 0.24 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC32249 Disease Relevance 0 Pain Relevance 0
Metabolism and circadian clocks are tightly intertwined: clock genes drive metabolism, and various metabolic parameters affect clock genes, producing a reciprocal feedback relationship.
Regulation (affect) of clock
17) Confidence 0.21 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2943104 Disease Relevance 0.15 Pain Relevance 0.04
Due to its strong association to energy status, deregulation of the PPARs-circadian clock system is believed to contribute, at least in part, to the development of metabolic syndrome.
Regulation (deregulation) of clock associated with metabolic syndrome
18) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.30 Pain Relevance 0
The functions of nuclear receptors in regulating circadian clock and physiology have been extensively discussed in several recent papers [51, 52] thus this paper will focus on PPARs.
Regulation (regulating) of clock
19) Confidence 0.21 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.08 Pain Relevance 0
Endogenous retinal dopamine and GABA, although not necessary for retinal PER2::LUC rhythms generation, were found to play key roles in regulating the retinal circadian clock: mediating light resetting of rhythmic phase and influencing the amplitude of retinal PER2::LUC rhythms, respectively.
Regulation (regulating) of clock associated with gaba and dopamine
20) Confidence 0.21 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.09 Pain Relevance 0.24

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