INT17039

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Context Info
Confidence 0.27
First Reported 1983
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.22
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hr) DNA binding (Hr)
Anatomy Link Frequency
fourth ventricle 1
respiratory 1
Hr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 12 99.84 Very High Very High Very High
narcan 4 99.84 Very High Very High Very High
cva 44 98.64 Very High Very High Very High
parabrachial 2 98.56 Very High Very High Very High
Pain 12 98.52 Very High Very High Very High
Central grey 2 98.28 Very High Very High Very High
Enkephalin 4 93.76 High High
palliative 4 93.20 High High
agonist 1 92.88 High High
antagonist 2 92.36 High High
Disease Link Frequency Relevance Heat
Disease 15 100.00 Very High Very High Very High
Metastasis 4 99.52 Very High Very High Very High
Prostate Cancer 24 98.88 Very High Very High Very High
Hemorrhage 48 98.64 Very High Very High Very High
Urological Neuroanatomy 2 98.28 Very High Very High Very High
Borrelia Infection 3 97.88 Very High Very High Very High
Pain 6 96.76 Very High Very High Very High
Anxiety Disorder 4 95.00 High High
Diabetic Neuropathy 7 87.92 High High
Cancer 4 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Pain and depression were major detrimental factors affecting the physical and mental aspects of the HrQOL respectively.
Regulation (affecting) of HrQOL
1) Confidence 0.27 Published 2009 Journal Acta Neurol. Scand. Section Body Doc Link 18976321 Disease Relevance 0.16 Pain Relevance 0
It remains unclear whether changes in mean HR or the variability of HR are specifically related to the noxious stimulus (i.e. pain).
Spec (whether) Regulation (changes) of HR associated with pain
2) Confidence 0.23 Published 1999 Journal Pediatr. Res. Section Abstract Doc Link 10203144 Disease Relevance 0.23 Pain Relevance 0.31
The potentially fatal Jarisch-Herxheimer reaction (J-HR), which invariably follows tetracycline treatment of the disease, was unaffected by naloxone, 30-40 mg intravenously, but was diminished by meptazinol, 300-500 mg intravenously.
Neg (unaffected) Regulation (unaffected) of J-HR associated with narcan and disease
3) Confidence 0.20 Published 1983 Journal Lancet Section Abstract Doc Link 6132178 Disease Relevance 0.48 Pain Relevance 0.50
Changes in these functions also often affect HR-QOL in patients with more advanced local stages of prostate cancer or metastatic disease.
Regulation (affect) of HR-QOL associated with prostate cancer and metastasis
4) Confidence 0.16 Published 2003 Journal Pharmacoeconomics Section Abstract Doc Link 12600219 Disease Relevance 0.83 Pain Relevance 0.07
Monotherapy with antiandrogens as endocrine treatment may be the treatment alternative that affects HR-QOL the least.
Regulation (affects) of HR-QOL
5) Confidence 0.16 Published 2003 Journal Pharmacoeconomics Section Abstract Doc Link 12600219 Disease Relevance 0.81 Pain Relevance 0.09
The importance of HR-QOL and associated research in prostate cancer is being more and more appreciated.
Regulation (importance) of HR-QOL associated with prostate cancer
6) Confidence 0.16 Published 2003 Journal Pharmacoeconomics Section Abstract Doc Link 12600219 Disease Relevance 0.62 Pain Relevance 0
Moreover, HR-QOL in these patients is also affected by endocrine treatment aiming to castrate the patient.
Regulation (affected) of HR-QOL
7) Confidence 0.16 Published 2003 Journal Pharmacoeconomics Section Abstract Doc Link 12600219 Disease Relevance 0.83 Pain Relevance 0.08
The occupational health intervention for the HR-IG was effective in controlling sickness absence.
Regulation (effective) of HR-IG
8) Confidence 0.07 Published 2008 Journal Occupational and Environmental Medicine Section Body Doc Link PMC2564865 Disease Relevance 0 Pain Relevance 0
It is impossible to explain the changes in HR-HF observed in the present study only on the basis of the change in respiratory control.


Regulation (changes) of HR-HF in respiratory
9) Confidence 0.06 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004820 Disease Relevance 0.86 Pain Relevance 0.31
Microinjections of DAMGO into the periaqueductal gray, parabrachial nucleus, or fourth ventricle structures 1-2 mm away from the LC had no effects on the development of an HR CR.
Neg (no) Regulation (effects) of HR CR in fourth ventricle associated with locus ceruleus, central grey and parabrachial
10) Confidence 0.06 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1869918 Disease Relevance 0.17 Pain Relevance 0.60
The adverse effect of DAMGO on the HR CR could be reversed with naltrexone pretreatment.
Regulation (effect) of HR CR
11) Confidence 0.03 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1869918 Disease Relevance 0.17 Pain Relevance 0.62
NF1 visibility and school problems did not influence HR-QOL.
Neg (not) Regulation (influence) of HR-QOL
12) Confidence 0.00 Published 2009 Journal J. Pediatr. Section Body Doc Link 18950800 Disease Relevance 0.06 Pain Relevance 0

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