INT17041

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Context Info
Confidence 0.66
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 5.31
Pain Relevance 7.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER1) protein binding transcription factor activity (PER1) cytoplasm (PER1)
signal transducer activity (PER1)
Anatomy Link Frequency
muscles 1
SCN 1
PGE2 1
PER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 588 99.76 Very High Very High Very High
Cancer pain 3 99.66 Very High Very High Very High
Opioid 75 99.10 Very High Very High Very High
Migraine 4 98.78 Very High Very High Very High
Neuropeptide 4 98.48 Very High Very High Very High
Inflammation 38 98.40 Very High Very High Very High
Serotonin 14 98.10 Very High Very High Very High
sSRI 4 97.20 Very High Very High Very High
fluoxetine 12 97.16 Very High Very High Very High
agonist 23 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 32 99.84 Very High Very High Very High
Cancer Pain 3 99.66 Very High Very High Very High
Headache 5 98.78 Very High Very High Very High
INFLAMMATION 51 98.40 Very High Very High Very High
Breast Cancer 28 98.24 Very High Very High Very High
Colorectal Cancer 36 98.16 Very High Very High Very High
Infection 23 97.08 Very High Very High Very High
Malaria 113 96.88 Very High Very High Very High
Pain 65 96.00 Very High Very High Very High
Cancer 53 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei.
Gene_expression (expression) of Per associated with opioid
1) Confidence 0.66 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.56
Moreover, we show that fentanyl induces a strong attenuation of light-induced Syrian hamster Period 1 (shPer1) gene expression during the night.
Gene_expression (expression) of shPer1
2) Confidence 0.66 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15978007 Disease Relevance 0 Pain Relevance 0.56
Expression of Per1/2, Rev-erbalpha/beta and Roralpha/beta in the SCN was not modified after fluoxetine or (+)8-OH-DPAT injection.
Gene_expression (Expression) of Per1 associated with fluoxetine
3) Confidence 0.65 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18190911 Disease Relevance 0.08 Pain Relevance 0.51
In nocturnal rodents, injections during the subjective day of the 5-HT1A/7 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or its positive enantiomer, induce behavioral phase-advances in correlation with decreased expression of two clock genes, Per1/2.
Gene_expression (expression) of Per1 associated with agonist
4) Confidence 0.65 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18190911 Disease Relevance 0.08 Pain Relevance 0.30
Light responses of Per1 and Rorbeta expression at CT0 and those of Per2 and Rev-erbalpha at CT12 were markedly altered by serotonergic activation.
Gene_expression (expression) of Per1
5) Confidence 0.65 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18190911 Disease Relevance 0.07 Pain Relevance 0.49
The phase-shifting effects of exercise on mammalian circadian rhythms are thought to be mediated by inputs to SCN neurons (these include serotonin [24], neuropeptide Y [25], and melatonin [13,26]) and ultimately lead to acute changes in SCN Per1 and Per2 expression [27].
Gene_expression (expression) of Per1 in SCN associated with neuropeptide and serotonin
6) Confidence 0.63 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.10
Quantitative RT-PCR indicated that the core circadian-clock genes Bmal1, Per1, and Per2 and selected mouse orthologs of the 44 putative circadian genes exhibited circadian regulation in mSkM (Figure 3).
Gene_expression (genes) of Per1
7) Confidence 0.54 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.06 Pain Relevance 0
The ankle twitch produced by PerL alone had about the same contraction time as that of all the muscles together.
Gene_expression (produced) of PerL in muscles
8) Confidence 0.54 Published 1991 Journal Muscle Nerve Section Abstract Doc Link 1870633 Disease Relevance 0 Pain Relevance 0.07
Similarly, other activities associated with malaria infection risk are the gold mining industry in the Southern jungle areas confined mainly to the beaches of the Inambari and Madre de Dios rivers, and rice production in the northern coastal areas of Perú due to inappropriate cleaning of the irrigation systems [37].
Gene_expression (production) of Per associated with malaria and infection
9) Confidence 0.54 Published 2009 Journal Malar J Section Body Doc Link PMC2714521 Disease Relevance 0.69 Pain Relevance 0
Maternal separation per se is a great source of stress for newborns.
Gene_expression (source) of per se associated with stress
10) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2662428 Disease Relevance 0.26 Pain Relevance 0.03
However, acute phase advances in SCN Per1 and Per2 expression in response to exercise have been observed in hamsters [27].
Gene_expression (expression) of Per1
11) Confidence 0.49 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.06
Quantitative RT-PCR indicated that the core circadian-clock genes Bmal1, Per1, and Per2 and selected mouse orthologs of the 44 putative circadian genes exhibited circadian regulation in mSkM (Figure 3).
Gene_expression (genes) of circadian-clock
12) Confidence 0.47 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.06 Pain Relevance 0
In contrast, we have not observed changes in Per1 levels in breast cancer cells upon CSNK1E suppression, and we failed to detect effects on cell viability after Per1 overexpression (data not shown).
Gene_expression (overexpression) of Per1 associated with breast cancer
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.89 Pain Relevance 0
interested in the “absolute” power statistic per se , but interested in
Gene_expression (interested) of per se
14) Confidence 0.13 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0 Pain Relevance 0
Protein quantification (BCA Protein Assay, Pierce Biotechnology, Rockford IL, USA) was done for further normalization of cocaine levels measured and the levels are expressed per 100 µg protein.


Gene_expression (expressed) of per associated with cocaine
15) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899232 Disease Relevance 0 Pain Relevance 0.25
An unchanged cerebral net exchange could furthermore involve changes in BBB function per se through a compensatory increase in the unidirectional cerebral efflux of phenylalanine, a parameter that was not assessed in the present study.
Gene_expression (function) of per se
16) Confidence 0.11 Published 2010 Journal Crit Care Section Body Doc Link PMC2875531 Disease Relevance 0.27 Pain Relevance 0.08
Following a single 15-min immersion in cocaine solution, cocaine levels in larvae corresponded to 0.4–0.6 ng per 100 µg protein and 9–12 ng per 100 µg protein for the 1.5 and 30 µM doses, respectively.
Gene_expression (corresponded) of per associated with cocaine
17) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899232 Disease Relevance 0.06 Pain Relevance 0.74
Following a single 15-min immersion in cocaine solution, cocaine levels in larvae corresponded to 0.4–0.6 ng per 100 µg protein and 9–12 ng per 100 µg protein for the 1.5 and 30 µM doses, respectively.
Gene_expression (corresponded) of per associated with cocaine
18) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899232 Disease Relevance 0.06 Pain Relevance 0.77
While there is a paucity of good-quality research concerning the risks and benefits of the long-term use of opioids for chronic non-cancer pain, their efficacy per se is acknowledged in these patients (4).
Gene_expression (acknowledged) of per se associated with cancer pain and opioid
19) Confidence 0.09 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC1974804 Disease Relevance 1.09 Pain Relevance 1.71
In this study we present evidence that cocaine alters the expression of at least two principal circadian genes of the Bmal and Per families, and genes encoding for melatonin receptors, that mediate the circadian message throughout the organism.
Gene_expression (expression) of Per associated with cocaine
20) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899232 Disease Relevance 0 Pain Relevance 0.32

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