INT170438

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Context Info
Confidence 0.04
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.03
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
ear 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 668 100.00 Very High Very High Very High
Nerve growth factor 49 100.00 Very High Very High Very High
Antihistamine 2 99.60 Very High Very High Very High
depression 3 98.32 Very High Very High Very High
antagonist 1 97.52 Very High Very High Very High
cytokine 2 90.52 High High
Potency 9 77.32 Quite High
Peripheral nervous system 1 77.24 Quite High
imagery 3 50.00 Quite Low
c fibre 3 40.32 Quite Low
Disease Link Frequency Relevance Heat
Eczema 108 99.08 Very High Very High Very High
Depression 3 98.32 Very High Very High Very High
Contact Dermatitis 1 85.32 High High
Pruritus 24 83.68 Quite High
Reprotox - General 2 6 77.32 Quite High
Hypersensitivity 7 32.80 Quite Low
Disease 4 27.52 Quite Low
Lichen 2 11.92 Low Low
Papular Skin Disease 2 10.64 Low Low
Erythema 3 10.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BODIPY Fl-SP and Oregon Green 488-SP produced an inhibition of IM similar to that of unlabeled SP.
Negative_regulation (inhibition) of Gene_expression (produced) of SP associated with substance p
1) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.10 Pain Relevance 0.83
BODIPY Fl-SP and Oregon Green 488-SP produced inhibition of IM and Ca++ elevations similar to that produced by unlabeled SP.
Negative_regulation (inhibition) of Gene_expression (produced) of SP associated with substance p
2) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.08 Pain Relevance 0.96
BODIPY Fl-SP and Oregon Green 488-SP produced an inhibition of IM similar to that of unlabeled SP.
Negative_regulation (inhibition) of Gene_expression (produced) of SP associated with substance p
3) Confidence 0.04 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.10 Pain Relevance 0.79
, IL-6 and GM-CSF in the affected ear tissues, unlike other histamine H1 receptor antagonists.29-31 From these results, olopatadine is suggested to exerts its effect on AD not only by antihistamine effect but also by suppressing the production of NGF and SP.
Negative_regulation (suppressing) of Gene_expression (production) of SP in ear associated with nerve growth factor, antihistamine, antagonist, eczema and substance p
4) Confidence 0.03 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.76 Pain Relevance 0.84

General Comments

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