INT170439

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Context Info
Confidence 0.10
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.30
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Spr) nucleus (Spr) cytoplasm (Spr)
Anatomy Link Frequency
ovary 1
Spr (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 880 99.12 Very High Very High Very High
agonist 16 83.76 Quite High
Inflammation 8 76.56 Quite High
depression 4 74.32 Quite High
Neurotransmitter 8 72.28 Quite High
Potency 12 69.12 Quite High
imagery 4 50.00 Quite Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
opioid receptor 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 76.56 Quite High
Hypersensitivity 4 75.60 Quite High
Depression 4 74.32 Quite High
Nociception 8 74.28 Quite High
Reprotox - General 2 8 5.00 Very Low Very Low Very Low
Tics 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the SPR expressed in CHO cells results in an elevation in intracellular Ca++ [7].
Positive_regulation (Activation) of SPR
1) Confidence 0.10 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.81
An important determinant of the usefulness of the SP conjugates is their ability to bind to and activate the SPR.
Positive_regulation (activate) of SPR associated with substance p
2) Confidence 0.09 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.72
When transfected into Chinese hamster ovary (CHO) cells, activation of the SPR results in an increase in intracellular Ca++ [5], accumulation of inositol phosphates and cAMP formation [6].
Positive_regulation (activation) of SPR in ovary
3) Confidence 0.06 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.23 Pain Relevance 0.41
The primary biological response following activation of the ganglionic SPR is inhibition of the M-type K+ current, IM.
Positive_regulation (activation) of SPR
4) Confidence 0.06 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.07 Pain Relevance 0.73

General Comments

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