INT170447

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Context Info
Confidence 0.01
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.10
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pax3, Spr) cell proliferation (Pax3) mitochondrion (Spr)
DNA binding (Pax3) cytoplasm (Spr)
Pax3 (Mus musculus)
Spr (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 1980 100.00 Very High Very High Very High
Potency 27 97.92 Very High Very High Very High
imagery 9 50.00 Quite Low
Neuropeptide 9 35.68 Quite Low
Opioid 9 13.84 Low Low
agonist 36 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
opioid receptor 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 18 98.32 Very High Very High Very High
Tics 9 5.28 Low Low
Nociception 18 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dose-response curves for the ability of the SP analogs to produce Ca++elevations upon binding to the SPR were obtained as previously described [5].
SP Binding (binding) of SPR associated with substance p
1) Confidence 0.01 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.48
Therefore, an important characteristic of the fluorescent SP analogs is their ability to bind to the SPR and to fluoresce under physiological conditions.
SP Binding (bind) of SPR associated with substance p
2) Confidence 0.01 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.49
Therefore, the ability of each of the fluorescent SP analogs to compete with [125I] SP binding to the SPR was assessed using a heterologous expression system, rSPR-expressing CHO cells.
SP Binding (binding) of SPR associated with substance p
3) Confidence 0.01 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.73
The evidence presented here suggests that four of the analogs, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP and tetramethylrhodamine-SP, are acting specifically at the SPR.
SP Binding (acting) of SPR associated with substance p
4) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.53
The evidence presented here suggests that four of the analogs, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP and tetramethylrhodamine-SP, are acting specifically at the SPR.
SP Binding (acting) of SPR associated with substance p
5) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.52
The evidence presented here suggests that four of the analogs, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP and tetramethylrhodamine-SP, are acting specifically at the SPR.
SP Binding (acting) of SPR associated with substance p
6) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.52
The evidence presented here suggests that four of the analogs, BODIPY Fl-SP, fluorescein-SP, Oregon Green 488-SP and tetramethylrhodamine-SP, are acting specifically at the SPR.
tetramethylrhodamine-SP Binding (acting) of SPR associated with substance p
7) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.52
Therefore, tetramethylrhodamine-SP is capable of binding to the SPR and activating Ca++ responses, but has a decreased potency for inhibiting IM.
tetramethylrhodamine-SP Binding (binding) of SPR associated with reprotox - general 2, potency and substance p
8) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0.10 Pain Relevance 0.80
Therefore, the ability of each of the fluorescent SP analogs to compete with [125I] SP binding to the SPR was assessed using a heterologous expression system, rSPR-expressing CHO cells.
SP Binding (binding) of SPR associated with substance p
9) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.78

General Comments

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