INT170455

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 66
Total Number 68
Disease Relevance 24.63
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
T cell 4
B cells 3
macrophages 2
skeletal muscle 2
dendritic cells 2
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 116 99.58 Very High Very High Very High
Spinal cord 24 98.96 Very High Very High Very High
Osteoarthritis 144 97.84 Very High Very High Very High
Inflammation 749 96.80 Very High Very High Very High
rheumatoid arthritis 737 96.80 Very High Very High Very High
cytokine 296 95.96 Very High Very High Very High
chemokine 4 94.44 High High
Inflammatory response 20 80.76 Quite High
Hippocampus 6 79.08 Quite High
Analgesic 1 75.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 879 99.96 Very High Very High Very High
Systemic Lupus Erythematosus 91 99.68 Very High Very High Very High
Stress 126 99.34 Very High Very High Very High
Autoimmune Disease 233 99.24 Very High Very High Very High
Targeted Disruption 138 99.06 Very High Very High Very High
Stomach Cancer 37 99.00 Very High Very High Very High
Eclampsia 54 98.60 Very High Very High Very High
Skin Cancer 29 98.58 Very High Very High Very High
Shock 159 97.92 Very High Very High Very High
Frailty 161 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for CTA, DNA methylation participates in regulation of the expression of the three classes of human leukocyte antigen class I antigens: HLA-A; HLA-B, and HLA-C, which are CpG-rich at their gene promoters.
Gene_expression (expression) of class I in leukocyte
1) Confidence 0.75 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.55 Pain Relevance 0
For quantification of MHC class I and nNOS expressions, 3-mm portions of lumbar spinal cord (L4-L6 segments) were cut from the right (contralateral) and left (ipsilateral to the axotomy) sides.
Gene_expression (expressions) of class I in spinal cord associated with spinal cord
2) Confidence 0.75 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0 Pain Relevance 0.10
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Gene_expression (expressed) of class I in B cells
3) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Half of the responses were found in patients not expressing the predicted restricting HLA class I allele.
Neg (not) Gene_expression (expressing) of class I
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.16 Pain Relevance 0
Unlike the results of our recent study identifying WNV CD8+ T cell epitopes, where reactivity to four dominating epitopes were found in almost all patients expressing the restricting HLA class I allele [10], the CD8+ T cell epitopes identified in the present study maximally induced response in about 25% of patients bearing the appropriate HLA.
Gene_expression (expressing) of class I in T cell
5) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
In accordance with this, the fraction of explainable epitope responses improved to 58% (21 out of 36), when also considering HLA class I supertype matches between HLA class I alleles expressed by the patients and the HLA class I alleles used for selecting the epitopes.
Gene_expression (expressed) of class I
6) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0
The ERAP2 genetic diversity identified here has biological implications in terms of influencing the levels of MHC class I on the cell surface and likely downstream antigen presentation.
Gene_expression (levels) of class I
7) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.39 Pain Relevance 0
Further studies that correlate ERAP2 genotype with levels of MHC class I expression in other tissues, and with the presentation and recognition of specific antigens, are needed to more clearly define the influence of ERAP2 deficiency on immune response.
Gene_expression (expression) of class I
8) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.29 Pain Relevance 0.07
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Gene_expression (expression) of class I
9) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.08 Pain Relevance 0.44
The complex epitope recognition pattern in the WNV infected patients showed that not all peptides that induce a CTL response in one patient do so in all patients expressing the restricting HLA class I allele.
Gene_expression (expressing) of class I
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
Recently, the expression of the class I major histocompatibility complex (MHC I) was related to synaptic plasticity and to astrogliosis after peripheral nerve transection [22-26].
Gene_expression (expression) of class I in peripheral nerve
11) Confidence 0.75 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2885347 Disease Relevance 0.36 Pain Relevance 0.17
Knocking out MHC class I expression in the SLE prone mouse suggested an important role for CD8+ T cells in autoimmunity as it failed to develop SLE [62].
Gene_expression (expression) of class I in T cells associated with autoimmune disease and systemic lupus erythematosus
12) Confidence 0.75 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.76 Pain Relevance 0.24
In rats, the administration of nerve growth factor (NGF) has been shown to enhance the expression of the class I major histocompatibility complex (MHC) in neurons, but not in glial cells, and decrease the expression of the class II MHC in glias [4].
Gene_expression (expression) of class I in glial cells associated with nerve growth factor
13) Confidence 0.75 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936305 Disease Relevance 0.43 Pain Relevance 0.28
Fig. 2B) expressing MHC class I (Fig. 1E), toward the pb/im interface (dashed line).
Gene_expression (expressing) of class I
14) Confidence 0.75 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0 Pain Relevance 0
Fig. 1E, and detail 1F, show that major histocompatibility complex (MHC) class I molecules are not expressed by basal epithelial cells, but they are strongly expressed throughout the parabasal layer, including lower parabasal cells.
Neg (not) Gene_expression (expressed) of class I in epithelial cells
15) Confidence 0.75 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.16 Pain Relevance 0
None of the identified epitopes induced a response in all patients expressing the predicted restricting HLA class I allele.
Gene_expression (expressing) of class I
16) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0
An additional advantage of including TAP as an adjuvant is its ability to increase peptide transport of a number of immunogenic peptides simultaneously, thereby aiding in the delivery of diverse peptides for binding to most HLA (human major histocompatibility complex) class I alleles expressed in the immunized population.
Gene_expression (expressed) of class I
17) Confidence 0.75 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey

Background

Gene_expression (expression) of class I in primary visual cortex
18) Confidence 0.75 Published 2011 Journal Behav Brain Funct Section Title Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
In general, expression of class I HDACs tended to be higher in tumor samples compared to the corresponding normal tissue.
Gene_expression (expression) of class I associated with cancer
19) Confidence 0.75 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 1.07 Pain Relevance 0
The presence of functional ERAP2 and the resulting high levels of MHC class I may be beneficial in some situations (e.g., in response to tumors or pathogens) yet detrimental in others (e.g., in the case of auto-immunity).
Gene_expression (presence) of class I associated with cancer
20) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.77 Pain Relevance 0

General Comments

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