INT170469

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 11
Speculated 0
Reported most in Body
Documents 66
Total Number 71
Disease Relevance 11.90
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (THY1) endoplasmic reticulum (THY1) plasma membrane (THY1)
enzyme binding (THY1) cytoskeleton organization (THY1)
Anatomy Link Frequency
vesicles 5
stem cells 5
synovium 4
ovary 3
hematopoietic cell 3
THY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 677 99.24 Very High Very High Very High
rheumatoid arthritis 69 98.12 Very High Very High Very High
Glutamate 10 87.16 High High
imagery 25 82.80 Quite High
metalloproteinase 8 76.92 Quite High
Inflammation 306 76.80 Quite High
cytokine 239 75.88 Quite High
Arthritis 119 75.76 Quite High
fibrosis 24 75.16 Quite High
tetrodotoxin 50 61.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 198 99.70 Very High Very High Very High
Aging 71 99.20 Very High Very High Very High
Cancer 175 99.00 Very High Very High Very High
Peripheral Arterial Disease 104 98.96 Very High Very High Very High
Ganglion Cysts 48 98.52 Very High Very High Very High
Rheumatoid Arthritis 70 98.12 Very High Very High Very High
Adhesions 81 96.40 Very High Very High Very High
Shock 9 94.36 High High
Osteogenic Sarcomas 8 93.92 High High
Diabetes Mellitus 83 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, T cells were depleted using anti-Thy1 (13.4.6), anti-CD4 (RL172), and anti-CD8 (3.168.8) followed by lysis using rabbit complement (Cedarlane Laboratories Limited; Hornby, Canada).
Gene_expression (using) of anti-Thy1 in T cells
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.12 Pain Relevance 0.04
It is generally accepted that the most primitive and long-term human HSCs are characterized by the expression of CD133, Thy1 (CD90) and VEGFR2 and by a variable expression of CD34 and CD38 [68].
Gene_expression (expression) of CD90
2) Confidence 0.53 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0.08
It is generally accepted that the most primitive and long-term human HSCs are characterized by the expression of CD133, Thy1 (CD90) and VEGFR2 and by a variable expression of CD34 and CD38 [68].
Gene_expression (expression) of Thy1
3) Confidence 0.53 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.24 Pain Relevance 0.08
Here we found that in a group of four PT/ACL pairs the intensity of expression of CD90 was consistently lower in the ACL as compared to the patellar and the expression of D7 FIB was consistently higher, whereas the pattern of response was inconsistent in the other markers.
Gene_expression (expression) of CD90
4) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.13
Tendon cells have been shown to express the human fibroblastic markers D7-FIB [11,12] and CD90 as well as other markers expressed by MSCs (eg.
Gene_expression (express) of CD90 in Tendon cells
5) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.15
However, differences in the intensity of expression of CD90 have been seen in other mesenchymal tissues; e.g. between human bone marrow or synovial-derived MSCs with the expression being higher in cells derived from the synovium [13].
Gene_expression (expression) of CD90 in synovium
6) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.14 Pain Relevance 0
Differences in intensity of expression of CD90 have been seen between MSC's derived from synovial tissue and bone marrow MSCs obtained from humans with the expression being higher in cells derived from the synovium [13].
Gene_expression (expression) of CD90 in synovium
7) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.20 Pain Relevance 0.06
The responses in the PT appear to be similar for both rat and human, both in expression of CD90 and reactivity to dexamethasone, indicating therefore that this pattern of response is not to be species specific.
Gene_expression (expression) of CD90 associated with dexamethasone
8) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.21 Pain Relevance 0.18
In the rat, the intensity of expression of CD90 was also higher in the PT cells as compared to the Achilles and tail cells.
Gene_expression (expression) of CD90 in tail
9) Confidence 0.52 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.12 Pain Relevance 0.09
The hADSCs expressed MSC-specific cell type markers including CD13, CD44, CD90, and CD166, however, did not express CD14, CD34, and CD45 indicating that hADSCs in this study were of mesenchymal origin.
Gene_expression (expressed) of CD90
10) Confidence 0.51 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.31 Pain Relevance 0.05
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD90 in stem cells associated with obesity
11) Confidence 0.51 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.22 Pain Relevance 0.06
As shown in Figure 1b, more than 95% of the adipose tissue-derived hMSCs expressed MSC-specific markers, including CD13, CD44 (endoglin), CD90 (Thy-1), and CD166, but did not express markers for hematopoietic stem cells, including CD14, CD34, and CD45.
Gene_expression (expressed) of CD90 in hematopoietic stem cells associated with obesity
12) Confidence 0.51 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.32 Pain Relevance 0.06
As shown in Figure 1b, more than 95% of the adipose tissue-derived hMSCs expressed MSC-specific markers, including CD13, CD44 (endoglin), CD90 (Thy-1), and CD166, but did not express markers for hematopoietic stem cells, including CD14, CD34, and CD45.
Gene_expression (expressed) of Thy-1 in hematopoietic stem cells associated with obesity
13) Confidence 0.51 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.32 Pain Relevance 0.06
1), CD44 (endoglin), CD49b, CD90 (Thy-1) and CD166, but did not express cell type-specific markers for hematopoietic stem cell (HSC) including CD14, CD34, CD45 and HLA-DR (Figure 2A and Table 1).
Neg (not) Gene_expression (express) of Thy-1 in hematopoietic stem cell
14) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0
The examined stem cell markers, CD44, CD73, CD166, CD105, CD90 and STRO1 showed stable expression level during the whole expansion period proving the results obtained by FACS analyses.
Gene_expression (expression) of CD90 in stem cell
15) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0
Although the literature is limited, tendon cells have been shown to express a number of markers including the human fibroblastic markers D7-FIB [11,12] and CD90 (data not shown) as well as other markers characteristic of mesenchymal cells (CD13 & CD44) (data not shown).
Gene_expression (express) of CD90 in mesenchymal cells
16) Confidence 0.45 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.13 Pain Relevance 0
Cell surface marker expression was also source dependent; CD90 was expressed at higher levels by PT cells and in both humans and rats whereas D7fib was expressed at lower levels by PT cells in humans.


Gene_expression (expressed) of CD90
17) Confidence 0.40 Published 2008 Journal J Orthop Surg Section Abstract Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.15
Tendon cells have been shown to express the human fibroblastic markers D7-FIB [11,12] and CD90 as well as other markers expressed by MSCs (eg.
Gene_expression (expressed) of CD90 in Tendon cells
18) Confidence 0.40 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.15
It was found that in all cases, ACL samples had a higher intensity of expression of the fibroblastic marker D7fib and a reduced CD90 expression compared to the patellar samples in all four pairs tested, however there were no consistent differences in CD13 or CD44.


Gene_expression (expression) of CD90
19) Confidence 0.40 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0.05 Pain Relevance 0.06
RGCs expressing Thy1.2 are shown in Figure 3B.
Gene_expression (expressing) of Thy1
20) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.07 Pain Relevance 0.07

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