INT170470

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 14.89
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
epithelial cells 3
T cells 3
Kupffer cells 2
monocytes 2
macrophages 1
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 75 100.00 Very High Very High Very High
Bile 20 100.00 Very High Very High Very High
Inflammation 534 98.76 Very High Very High Very High
cytokine 444 98.72 Very High Very High Very High
rheumatoid arthritis 319 98.60 Very High Very High Very High
medulla 5 96.36 Very High Very High Very High
Inflammatory mediators 15 95.64 Very High Very High Very High
agonist 132 93.76 High High
metalloproteinase 30 89.84 High High
chemokine 60 87.40 High High
Disease Link Frequency Relevance Heat
Injury 186 100.00 Very High Very High Very High
Fibrosis 123 100.00 Very High Very High Very High
Liver Disease 100 99.92 Very High Very High Very High
INFLAMMATION 590 98.76 Very High Very High Very High
Rheumatoid Arthritis 322 98.60 Very High Very High Very High
Gallstones 6 97.94 Very High Very High Very High
Obesity 102 97.80 Very High Very High Very High
Cirrhosis 214 97.72 Very High Very High Very High
Ovarian Cancer 3 97.12 Very High Very High Very High
Atherosclerotic Plaque 56 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that there is no in vivo neutralization of endotoxin-induced cytokine production, and consequently that there is no interaction with binding to LBP or the CD14 receptor.
CD14 Binding (binding) of associated with cytokine
1) Confidence 0.35 Published 2004 Journal Crit Care Section Body Doc Link PMC420063 Disease Relevance 0 Pain Relevance 0.10
In fact, there was a tendency for the endotoxin concentration in animals treated with tobramycin to be higher, which might be consistent with reduced binding to the CD14 receptor.
CD14 Spec (might) Binding (binding) of
2) Confidence 0.35 Published 2004 Journal Crit Care Section Body Doc Link PMC420063 Disease Relevance 0.20 Pain Relevance 0.08
This conclusion was reached after examining the relation between MHCII+CD16+ and CD14+CD16+ using the following approach.
CD14+ Spec (examining) Binding (relation) of
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.27 Pain Relevance 0.03
Positive selection was performed with the CD14 MicroBeads (Miltenyi Biotec, Auburn, CA, USA) that bind to CD14 on the surface of monocytes.
CD14 Binding (bind) of in monocytes
4) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.32 Pain Relevance 0.23
Positive selection was performed with the CD14 MicroBeads (Miltenyi Biotec, Auburn, CA, USA) that bind to CD14 on the surface of monocytes.
CD14 Binding (bind) of in monocytes
5) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.31 Pain Relevance 0.22
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
CD14 Binding (interacting) of in endometrium
6) Confidence 0.30 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.30 Pain Relevance 0.08
The use of anti-CD14 antibody confirms that the presence of CD14 is essential to TLR4 signalling.
CD14 Binding (presence) of
7) Confidence 0.26 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.29 Pain Relevance 0.03
MSC have been defined as the cells having plastic-adherence when maintained under standard culture conditions, must have the ability of osteogenic, adipogenic and chondrogenic differentiation, must express CD73, CD90, and CD105, and must lack expression of hematopoietic lineage markers c-kit, CD14, CD34, CD 45, CD 11b, CD 29, CD79?
CD14 Neg (lack) Binding (lineage) of
8) Confidence 0.26 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.35 Pain Relevance 0
The incubations with CD14 (10 ?
CD14 Binding (incubations) of
9) Confidence 0.23 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0
TLR4, which interacts with LPS-bound CD14, is constitutively expressed in circumventricular organs but also in the hypothalamus and medulla; in contrast to CD14, however, there is a downregulation of TLR4 mRNA in the brains of rats challenged by LPS [59].
CD14 Binding (bound) of in brains associated with medulla
10) Confidence 0.22 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.31 Pain Relevance 0.08
This antibody is capable of binding both sCD14 and mCD14.
sCD14 Binding (binding) of
11) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.25 Pain Relevance 0.25
This antibody is capable of binding both sCD14 and mCD14.
mCD14 Binding (binding) of
12) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.25 Pain Relevance 0.25
Similar association of CD14 primitive MDC with proliferating Ki67 epithelial cells was detected in ovarian cancers (unpublished data).
CD14 Binding (association) of in epithelial cells associated with ovarian cancer
13) Confidence 0.20 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.25 Pain Relevance 0
Detail, Fig. 1B, shows association of CD14 cells with the basement membrane and extension among basal epithelial cells.
CD14 Binding (association) of in epithelial cells
14) Confidence 0.19 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.26 Pain Relevance 0
Perivascular CD14 primitive MDC associated with basal (stem) epithelial cells.
CD14 Binding (associated) of in epithelial cells
15) Confidence 0.19 Published 2001 Journal BMC Dev Biol Section Abstract Doc Link PMC34117 Disease Relevance 0 Pain Relevance 0
Before quantifying the different populations, we tested whether tissue digestion might influence the detection of immune cell markers, by exposing PBMCs to the procedure or its components and subsequently staining for CD3, CD14, CD163, and CD20 (see Table 2 for experiment set-up).
CD14 Spec (might) Binding (staining) of in immune cell
16) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.11 Pain Relevance 0
Within hematopoietic cells, populations representing T-lymphocytes (CD3+), B-lymphocytes (CD20+) and monocytes (CD14+) could be recognized (Figure 2d).
CD14 Binding (recognized) of in B-lymphocytes
17) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.12 Pain Relevance 0.03
For sorting, PB or SF DC-enriched non-T cells stained with the same four markers were sorted using the Moflo flow cytometer (DAKO), gating on CD14-HLA-DR+ and either CD123+CD11c- or CD11c+CD123- cells, respectively.
CD14 Binding (gating) of in T cells
18) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.08 Pain Relevance 0.04
To address PRR surface expression on T cells, PBMCs from patients as well as from healthy controls were incubated with mAbs against CD4, CD14, CD28, TLR4 and TLR2, and were analysed by flow cytometry.
CD14 Spec (analysed) Binding (mAbs) of in T cells
19) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.51 Pain Relevance 0.31
Lipopolysaccharide, for example, binds to macrophages through the CD14 receptor and, in vitro, stimulates the production of IL-1?
CD14 Binding (binds) of in macrophages
20) Confidence 0.18 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.59 Pain Relevance 0.38

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