INT170482

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.73
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) Golgi apparatus (Mapk1)
protein complex (Mapk1) microtubule organizing center (Mapk1) cytoplasm (Mapk1)
Anatomy Link Frequency
thoracic aorta 4
hepatocytes 2
spinal cord dorsal horn 2
medulla 1
kidney cortex 1
Mapk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 35 99.64 Very High Very High Very High
Dorsal horn 8 99.16 Very High Very High Very High
Hippocampus 25 98.16 Very High Very High Very High
medulla 60 98.04 Very High Very High Very High
painful pain 4 97.24 Very High Very High Very High
Pain 60 96.04 Very High Very High Very High
Lasting pain 17 94.88 High High
Hyperalgesia 8 90.40 High High
Neuropathic pain 1 75.28 Quite High
Inflammation 7 74.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 396 100.00 Very High Very High Very High
Pain 82 96.68 Very High Very High Very High
Nervous System Injury 2 95.48 Very High Very High Very High
Hyperalgesia 9 90.40 High High
Bordatella Infection 7 81.44 Quite High
Neuropathic Pain 1 75.28 Quite High
INFLAMMATION 7 74.44 Quite High
Injury 4 71.20 Quite High
Ganglion Cysts 2 66.76 Quite High
Hepatocellular Cancer 1 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since cyclic AMP was found to exert a negative control of ERK1/2 activation in hepatocytes [35], it can be speculated that the decreases in ERK1/2 responses observed subsequent to inhibition of Gi function might be caused by an elevation of intracellular levels of cyclic AMP.
Regulation (control) of Gene_expression (activation) of ERK1/2 in hepatocytes
1) Confidence 0.43 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.14 Pain Relevance 0
Therefore, the aim of the present series of experiments is to assess the spatial- and temporal-related changes in phosphorylation (activation) and protein expression of ERKs, mainly ERK1 and ERK2, in the spinal cord dorsal horn, SI area and hippocampus under both physiological pain (transient pain) and pathological pain (persistent pain) states.
Regulation (changes) of Gene_expression (expression) of ERK2 in spinal cord dorsal horn associated with pain, lasting pain, dorsal horn, painful pain, hippocampus and spinal cord
2) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 1.64 Pain Relevance 1.61
Effect of STZ-induced diabetes on the expression of total and phosphorylated p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and medulla
Regulation (Effect) of Gene_expression (expression) of p38-MAPK in thoracic aorta associated with medulla and diabetes mellitus
3) Confidence 0.10 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.32 Pain Relevance 0.16
Effect of STZ-induced diabetes on the expression of total and phosphorylated p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and medulla
Regulation (Effect) of in medulla Gene_expression (expression) of p38-MAPK in thoracic aorta associated with medulla and diabetes mellitus
4) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.32 Pain Relevance 0.16
Effect of STZ-induced diabetes on the expression of total and phosphorylated p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and medulla
Regulation (Effect) of in kidney cortex Gene_expression (expression) of p38-MAPK in thoracic aorta associated with medulla and diabetes mellitus
5) Confidence 0.03 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.32 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox