INT17049

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1991
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 57
Total Number 59
Disease Relevance 35.33
Pain Relevance 6.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 21
lymphocytes 3
regulatory T cells 3
Plasma 1
blood 1
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 444 100.00 Very High Very High Very High
rheumatoid arthritis 88 99.76 Very High Very High Very High
spinal inflammation 162 99.68 Very High Very High Very High
Inflammation 398 99.44 Very High Very High Very High
psoriasis 54 99.32 Very High Very High Very High
Pain 41 97.12 Very High Very High Very High
addiction 59 96.92 Very High Very High Very High
agonist 19 96.32 Very High Very High Very High
chemokine 69 93.76 High High
fibrosis 94 92.56 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1679 100.00 Very High Very High Very High
Infection 648 100.00 Very High Very High Very High
Influenza Virus Infection 196 100.00 Very High Very High Very High
Chronic Fatigue Syndrome 78 99.84 Very High Very High Very High
Rheumatoid Arthritis 92 99.76 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 250 99.72 Very High Very High Very High
Low Back Pain 172 99.68 Very High Very High Very High
INFLAMMATION 434 99.44 Very High Very High Very High
Psoriasis 66 99.32 Very High Very High Very High
Mycobacterial Infection 113 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Until recently, the level of CD4 indicating ART differed between developed and developing countries.
Localization (indicating) of CD4
1) Confidence 0.75 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.85 Pain Relevance 0.03
Possibly this is caused by the cellular reaction to rapid internalization of CD4, which is induced by antibody binding but not by DARPin binding [8], [23].
Localization (internalization) of CD4
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.34 Pain Relevance 0
Although still not completely understood, emerging data indicate that the generation of CD4(+) and CD8(+) T cells are important for the clearance of HCV.
Localization (generation) of CD4 in T cells associated with hepatitis c virus infection
3) Confidence 0.73 Published 2009 Journal Human vaccines Section Abstract Doc Link 19246990 Disease Relevance 0.90 Pain Relevance 0
Cells were then surface stained with anti-CD4 QD605, anti-CD8 pacific orange (Invitrogen, Carlsbad, CA), anti-CD27 FITC (Beckton Dickinson, Franklin Lakes, NJ), and anti-CD45RO (Beckman Coulter, Fullerton, CA) for 20 minutes at room temperature, washed twice in PBS, then fixed and permeabilized by incubating in BD Cytofix Cytoperm solution for 20 minutes at 4°C.
Localization (orange) of anti-CD4
4) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799527 Disease Relevance 0 Pain Relevance 0.03
[Therapeutic use of a monoclonal, anti-CD4 antibody in refractory rheumatoid polyarthritis.
Localization (use) of CD4 associated with arthritis
5) Confidence 0.73 Published 1991 Journal Rev Rhum Mal Osteoartic Section Title Doc Link 1871515 Disease Relevance 0.18 Pain Relevance 0.08
Numbers of circulating CD4+CD25high regulatory T cells decrease in patients with active SLE [125-127] while clinical remission is associated with elevated or normal CD4+CD25high regulatory T cell frequency [128-131].
Localization (decrease) of CD4 in regulatory T cell associated with systemic lupus erythematosus
6) Confidence 0.72 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.18 Pain Relevance 0.21
Thus, CD4+CD25high regulatory T cells may be actively recruited or be generated de novo at sites of inflammation (or both).
Localization (recruited) of CD4 in regulatory T cells associated with inflammation
7) Confidence 0.72 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.88 Pain Relevance 0.41
CD4+CD25high regulatory T cells from RA subjects are capable of suppressing the production of IFN-?
Localization (regulatory T cells) of CD4 in regulatory T cells associated with rheumatoid arthritis
8) Confidence 0.72 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.80 Pain Relevance 0.41
A case is presented of a 34-year-old man with a 10-year history of HIV infection (CD4 counts 750-1100/mm3) who initially presented with upper right quadrant pain that was crampy, achy and periumbilical, not affected by food, and was indicative of early-stage acalculous cholecystitis.
Localization (presented) of CD4 in upper associated with pain, acquired immune deficiency syndrome or hiv infection, acalculous cholecystitis and infection
9) Confidence 0.71 Published 1995 Journal AIDS Clin Care Section Abstract Doc Link 11362836 Disease Relevance 0.90 Pain Relevance 0.40
Treg [19], and CD4+CD25?
Localization (Treg) of CD4+
10) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.22 Pain Relevance 0
Many accessory molecules involved in the so-called immunologic synapse, have been targeted by biologic therapies (alefacept and efalizumab) which showed a significant efficacy in psoriasis by interfering with the effector CD4+ and CD8+ T lymphocyte activation and secretion of the cytokines (eg, IFN-?
Localization (secretion) of CD4 in T lymphocyte associated with psoriasis and cytokine
11) Confidence 0.65 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721342 Disease Relevance 0.93 Pain Relevance 0.42
CD4+ T-cells may react against cell or tissue antigens and secrete cytokines that induce local inflammation and activate macrophages.
Localization (secrete) of CD4 in T-cells associated with inflammation and cytokine
12) Confidence 0.62 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.20 Pain Relevance 0.31
Because our patients were on an effective HAART for a long period of time, the release of virus from latently infected reactivated CD4 cells, rather than an ongoing viral replication, could be a likely explanation of these findings.34 This possible explanation is supported by the adherence rates reported by patients presenting viral blips, which did not differ and were even higher than those of patients with complete control of viral replication, and by the observation that 100% of patients on HAART presented a viral load <400 copies/mL.
Localization (release) of CD4
13) Confidence 0.62 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875721 Disease Relevance 0.09 Pain Relevance 0
Patients who have an adequate CD4 response to HAART may have antimycobacterial treatment safely withdrawn following resolution of focal involvement.
Localization (response) of CD4
14) Confidence 0.61 Published 2007 Journal J Transl Med Section Body Doc Link PMC2213635 Disease Relevance 0.77 Pain Relevance 0.08
Clinical relevance of CD4+CD28- T cells in ankylosing spondylitis
Localization (relevance) of CD4+ in T cells associated with spinal inflammation
15) Confidence 0.58 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0.85 Pain Relevance 0.43
in AS, but the rapid release of this T-helper-1 type cytokine by CD4+CD28- T cells may be important in sustaining synovitis, which is comparable to its role in rheumatoid synovitis [35].
Localization (release) of CD4+ in T cells associated with spinal inflammation, synovitis and cytokine
16) Confidence 0.58 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.23 Pain Relevance 0.65
We separated CD4+CD25?
Localization (separated) of CD4
17) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.17 Pain Relevance 0.09
treated resting memory CD4+ T cells (Fig 3A), it is not totally unexpected that addition of IL-2 to cultures of resting memory CD4+CD25?
Localization (cultures) of CD4 in T cells
18) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.22 Pain Relevance 0.13
Analysis of T-lymphocyte subsets in BAL fluid indicates that, in patients with bronchiectasis due to mustard gas exposed, both the percentage and total numbers of CD4 T cells increase and the percentage of CD8 T cells decreases (See Table 4).
Localization (increase) of CD4 in T cells associated with bronchiectasis
19) Confidence 0.56 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 1.59 Pain Relevance 0.39
Multiparametric flow cytometry assays were performed to determine the relative importance of the subpopulations of influenza-specific CD3+CD4+ and CD3+CD8+ T cells that produce IL-2, IFN-?
Spec (determine) Localization (importance) of CD4 in T cells associated with influenza virus infection
20) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.75 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox