INT170504

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 60
Total Number 60
Disease Relevance 19.10
Pain Relevance 8.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
neurons 10
myocytes 4
glial cells 4
urinary bladder 2
BSM 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 335 100.00 Very High Very High Very High
Hippocampus 184 100.00 Very High Very High Very High
Morphine 78 100.00 Very High Very High Very High
Glutamate 326 99.98 Very High Very High Very High
depression 108 99.64 Very High Very High Very High
Neurotransmitter 63 97.80 Very High Very High Very High
Glutamate receptor 16 97.60 Very High Very High Very High
nMDA receptor 128 97.36 Very High Very High Very High
excitatory amino acid 3 96.60 Very High Very High Very High
agonist 96 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 264 99.68 Very High Very High Very High
Drug Induced Neurotoxicity 97 99.68 Very High Very High Very High
Depression 108 99.64 Very High Very High Very High
Pressure And Volume Under Development 73 99.36 Very High Very High Very High
Targeted Disruption 480 99.14 Very High Very High Very High
Alzheimer's Dementia 80 99.12 Very High Very High Very High
Hypertrophy 10 99.06 Very High Very High Very High
Myocardial Infarction 10 98.72 Very High Very High Very High
Coronary Artery Disease 3 98.42 Very High Very High Very High
Death 472 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, using bioluminescence for imaging over long periods can also reveal other interesting phenomena, such as Ca2+ waves occurring across the entire animal, which were observed after kainate induced seizures (Figure 7D (n?
Positive_regulation (occurring) of Gene_expression (waves) of Ca2 associated with convulsion and imagery
1) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.28 Pain Relevance 0.08
However, other investigators have reported that the inactivation of Ca2+-ATPase is closely related with ischemic heart disease, heart failure, and hypertrophy of cardiac muscle; thus, as the intracellular Ca2+ concentration increases, the concentration of ryanodine receptor decreases, and in some cases, down regulation has been found to be associated with the decreased expression of its mRNA.23,24
Positive_regulation (increases) of Gene_expression (concentration) of Ca2 in heart associated with hypertrophy, coronary artery disease and myocardial infarction
2) Confidence 0.36 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.30 Pain Relevance 0
Increased Ca2+ signalling, Ca2+ extrusion from cells, and Glu transport into glial cells
Positive_regulation (Increased) of Gene_expression (extrusion) of Ca2 in glial cells associated with glutamate
3) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.18 Pain Relevance 0.16
Increased Ca2+ signalling, Ca2+ extrusion from cells, and Glu transport into glial cells
Positive_regulation (Increased) of Gene_expression (extrusion) of Ca2 in glial cells associated with glutamate
4) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.18 Pain Relevance 0.16
Superfusion of myocytes with Ang II (10 nM) induced acute increases of free systolic Ca2+i levels in both genotypes.
Positive_regulation (increases) of Gene_expression (levels) of Ca2 in myocytes
5) Confidence 0.25 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Focal Ca2+ transients are concurrent with sEJPs in mouse urinary bladder SMCs
Positive_regulation (transients) of Gene_expression (transients) of Ca2 in urinary bladder
6) Confidence 0.25 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.05
A participation of RhoA-mediated Ca2+ sensitization in the augmented ACh-induced contraction of BSM was demonstrated in this animal model of AHR.


Positive_regulation (mediated) of Gene_expression (sensitization) of Ca2 in BSM
7) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.39 Pain Relevance 0.07
The concentration of nicardipine used in the present study completely blocked high K+ (10–90 mM)-induced BSM contraction in Ca2+ (2.5 mM) containing normal Krebs-Henseleit solution (data not shown), indicating that voltage-dependent Ca2+ channels were completely blocked in this condition.
Positive_regulation (induced) of Gene_expression (contraction) of Ca2
8) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Moreover, it has also been reported that there is no difference between normal and antigen-induced AHR animals in ACh-induced increase in intracellular Ca2+ concentration in BSMs, irrespective of a great difference in ACh-induced BSM contraction [29,30].
Positive_regulation (increase) of Gene_expression (concentration) of Ca2
9) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0.08
Likewise, the ACh-induced, C3-sensitive Ca2+ sensitization of BSM contraction was significantly augmented in ?
Positive_regulation (augmented) of Gene_expression (sensitization) of Ca2
10) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.17 Pain Relevance 0
Addition of Ca2+ induced a concentration-dependent BSM contraction in both the sensitized control and OA-challenged groups.
Positive_regulation (induced) of Gene_expression (contraction) of Ca2
11) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
One of the important findings in the present study is that the C3-sensitive, RhoA-mediated Ca2+ sensitization in ACh-induced contraction was significantly augmented in BSMs of the repeatedly OA-challenged AHR mice (Figs. 2 and 3).
Positive_regulation (augmented) of Gene_expression (sensitization) of Ca2
12) Confidence 0.24 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.24 Pain Relevance 0.12
However, for comparative purposes and to be consistent with previous measurements in Ca2+ channels lacking ?
Positive_regulation (measurements) of Gene_expression (channels) of Ca2
13) Confidence 0.23 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.04
Thus the higher Ca2+ conductance of ?
Positive_regulation (higher) of Gene_expression (conductance) of Ca2
14) Confidence 0.23 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.03
Since control cells had a more negative half inactivation potential, the higher Ca2+ conductance of ?
Positive_regulation (higher) of Gene_expression (conductance) of Ca2
15) Confidence 0.23 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.04
In any case, the massive entry of Ca2+ induced by A?
Positive_regulation (entry) of Gene_expression (entry) of Ca2
16) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.32 Pain Relevance 0.18
The above findings indicate that mitochondrial Ca2+ overload contributes to the neurotoxicity induced by A?
Positive_regulation (contributes) of Gene_expression (overload) of Ca2 associated with drug induced neurotoxicity
17) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 1.30 Pain Relevance 0.42
Mitochondrial Ca2+ overload contributes to A?
Positive_regulation (overload) of Gene_expression (overload) of Ca2
18) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.90 Pain Relevance 0
We asked next for the contribution of mitochondrial Ca2+ overload to the apoptosis induced by A?
Positive_regulation (overload) of Gene_expression (overload) of Ca2 associated with apoptosis
19) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.83 Pain Relevance 0
Neurons but not glia undergo increases in [Ca2+]cyt after presentation of A?
Positive_regulation (increases) of Gene_expression (undergo) of Ca2 in Neurons
20) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox