INT170511

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Context Info
Confidence 0.21
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 2.18
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
myotubes 6
plasma 2
muscle 2
skeletal muscle 2
astrocytes 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 71 100.00 Very High Very High Very High
Neurotransmitter 12 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
Catecholamine 10 98.88 Very High Very High Very High
agonist 67 91.68 High High
Glutamate receptor 7 87.08 High High
Substantia nigra 7 82.48 Quite High
imagery 33 77.44 Quite High
long-term potentiation 101 76.84 Quite High
Glutamate 14 54.16 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 16 99.80 Very High Very High Very High
Brain Hemorrhage 18 91.32 High High
Ganglion Cysts 1 91.28 High High
Cv General 4 Under Development 6 90.88 High High
Death 46 89.92 High High
Thrombosis 28 89.52 High High
Vasculitis 1 87.76 High High
Pressure Volume 2 Under Development 2 86.64 High High
Apoptosis 21 81.04 Quite High
Body Weight 3 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the change in Ca2+ sensitization of BSM contraction, permeabilized BSMs were prepared as described previously [21] with minor modification.
Spec (determine) Regulation (change) of Localization (sensitization) of Ca2
1) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
In summary, the voltage-dependence of Ca2+ transients and the maximum cytosolic Ca2+ concentration during the transient were not significantly affected by partial or total absence of the ?
Neg (not) Spec (partial) Regulation (affected) of Localization (concentration) of Ca2 associated with addiction
2) Confidence 0.20 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.09
Taken together, our results suggest that the large and sustained entry of Ca2+ induced by A?
Regulation (large) of Localization (entry) of Ca2
3) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.77 Pain Relevance 0.05
A major pathway for Ca2+ entry in nonexcitable cells involves receptor-mediated release of intracellular Ca2+ stores, followed by activation of store-operated calcium (SOC) channels in the plasma membrane.
Regulation (followed) of Localization (release) of Ca2 in plasma
4) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442636 Disease Relevance 0.60 Pain Relevance 0.05
Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle

Background

Regulation (Modulation) of Localization (release) of Ca2 in skeletal muscle
5) Confidence 0.12 Published 2001 Journal BMC Physiol Section Title Doc Link PMC37314 Disease Relevance 0.08 Pain Relevance 0.03
Additionally, SK channels are potential targets for the action of neurotransmitters (i.e., serotonin, [170]) and peptides (i.e., endothelin, [171]) acting through the mobilization of intracellular Ca2+ in cultured striatal and cortical astrocytes.
Regulation (targets) of Localization (mobilization) of Ca2 in astrocytes associated with neurotransmitter and serotonin
6) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.06 Pain Relevance 0.14
1 subunits (also termed dihydropyridine receptors, DHPRs, in muscle) mechanically activate RyR1 and elicit SR Ca2+ release.
Regulation (elicit) of Localization (release) of Ca2 in muscle
7) Confidence 0.11 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.14 Pain Relevance 0
M) did not affect the increase of intracellular Ca2+ induced by applying KCl (50 mM).
Neg (not) Regulation (affect) of Localization (increase) of Ca2
8) Confidence 0.10 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
Modest effects on vesicular release and intracellular Ca2+ in PC12 cells were seen following acute exposure to 20 ?
Regulation (effects) of Localization (release) of Ca2 associated with pheochromocytoma
9) Confidence 0.06 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC1892123 Disease Relevance 0.32 Pain Relevance 0.23
Our data support the view that PKC activation is necessary for the inhibition of SK channels, but we cannot rule out an additional role for Ca2+ release and/or PIP2 depletion.
Regulation (role) of Localization (release) of Ca2
10) Confidence 0.05 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.09 Pain Relevance 0.10
In R163C Het myotubes, there was a small hyperpolarizing shift in SR Ca2+ release and a slight reduction in maximal release ([?
Regulation (shift) of Localization (release) of Ca2 in myotubes
11) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.05 Pain Relevance 0.18
In R163C Hom myotubes, the voltage dependence of SR Ca2+ release shifted to a greater extent and maximal release was substantially reduced (Fig. 1 and Table I).
Regulation (dependence) of Localization (release) of Ca2 in myotubes associated with addiction
12) Confidence 0.04 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.07 Pain Relevance 0.19
To assess directly the effects of the R163C mutation on voltage-triggered Ca2+ release, without complications from RYR1 tetramers having variable WT/mutant monomer stoichiometry, we initially compared Ca2+ transients of myotubes Hom for the R163C mutation with those of WT myotubes.
Regulation (effects) of Localization (release) of Ca2 in myotubes
13) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0 Pain Relevance 0

General Comments

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