INT170513

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Context Info
Confidence 0.65
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.06
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacng2) neurological system process (Cacng2)
Anatomy Link Frequency
neurons 1
synapse 1
Cacng2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal sensitization 1 93.84 High High
central sensitization 9 86.76 High High
nMDA receptor 5 80.40 Quite High
addiction 17 52.88 Quite High
Kinase C 18 50.08 Quite High
Hyperalgesia 4 27.04 Quite Low
Inflammation 9 26.52 Quite Low
spinal dorsal horn 7 19.40 Low Low
Glutamate 34 10.08 Low Low
Glutamate receptor 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 58.64 Quite High
Nociception 26 31.68 Quite Low
Hyperalgesia 5 27.04 Quite Low
INFLAMMATION 9 26.52 Quite Low
Inflammatory Pain 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the synapse, the C-termini of stargazin/TARP and CKAMP44 interact with the synaptic scaffold proteins such as PSD-95 that belongs to the membrane associated guanylate kinase (MAGUK) family
Gene_expression (/) of stargazin in synapse
1) Confidence 0.65 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0
2 or stargazin, which is expressed in neurons and is responsible for the stargazer mutation in mice [17].
Gene_expression (expressed) of stargazin in neurons
2) Confidence 0.41 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0.06 Pain Relevance 0.03
It has been showed that an over-expression of Stargazin increases the number of extra-synaptic AMPA receptors without affecting AMPA receptor-mediated synaptic transmission.
Gene_expression (expression) of Stargazin
3) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.16

General Comments

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