INT170514

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.56
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1) plasma membrane (Ryr1) cytoplasm (Ryr1)
Anatomy Link Frequency
myotubes 1
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 34 96.54 Very High Very High Very High
agonist 5 61.16 Quite High
Neurotransmitter 14 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 31 98.44 Very High Very High Very High
Channelopathies 34 74.64 Quite High
Disease 29 70.80 Quite High
Syndrome 12 44.08 Quite Low
Targeted Disruption 10 31.44 Quite Low
Hypokalemic Periodic Paralysis 58 11.52 Low Low
Dystonia 20 5.00 Very Low Very Low Very Low
Night Blindness 18 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for Hom R163C myotubes, hyperpolarizing shifts in the voltage dependence of Ca2+ release have also been reported for myotubes harvested from Y522S Hom mice (Chelu et al., 2006) or R615C Hom swine (Dietze et al., 2000), and for dyspedic myotubes expressing RYR1 constructs carrying several different MH mutations (Avila and Dirksen, 2001; Dirksen and Avila, 2004; Lyfenko et al., 2004).
Gene_expression (expressing) of RYR1 in myotubes associated with addiction and malignant hyperthermia
1) Confidence 0.49 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888063 Disease Relevance 0.10 Pain Relevance 0.12
Further, the interactions between DHPR subunits and RyR1 also are incompletely understood.
Gene_expression (subunits) of RyR1
2) Confidence 0.48 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0
Notably, a lower activation threshold for Ca2+ release was also found for RyR1 mutations, including a heterozygous RyR1 mutation in a MHS mouse model.
Gene_expression (mutation) of RyR1
3) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.24 Pain Relevance 0
Notably, a lower activation threshold for Ca2+ release was also found for RyR1 mutations, including a heterozygous RyR1 mutation in a MHS mouse model.
Gene_expression (mutations) of RyR1
4) Confidence 0.42 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.23 Pain Relevance 0

General Comments

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