INT170516

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 9.40
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
neurons 6
astrocytes 4
neuronal 2
plasma 2
pore 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 294 100.00 Very High Very High Very High
cINOD 298 99.84 Very High Very High Very High
tetrodotoxin 18 99.48 Very High Very High Very High
long-term potentiation 50 99.36 Very High Very High Very High
Hippocampus 62 99.00 Very High Very High Very High
addiction 73 98.80 Very High Very High Very High
antagonist 39 97.48 Very High Very High Very High
ASIC 4 97.48 Very High Very High Very High
Action potential 79 96.84 Very High Very High Very High
withdrawal 1 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 181 99.30 Very High Very High Very High
Drug Induced Neurotoxicity 81 99.20 Very High Very High Very High
Death 310 99.00 Very High Very High Very High
Neurodegenerative Disease 31 98.16 Very High Very High Very High
Arrhythmia Under Development 13 98.08 Very High Very High Very High
Pressure And Volume Under Development 16 96.28 Very High Very High Very High
Alzheimer's Dementia 76 96.08 Very High Very High Very High
Influenza Virus Infection 1 95.92 Very High Very High Very High
Toxicity 72 95.20 Very High Very High Very High
Increased Venous Pressure Under Development 74 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oscillatory rises in Ca2+ were absent or significantly reduced after incubation with the NADH-ubiquinone oxidoreductase (complex I) inhibitor, piericidin A (2 µM) (Figure 2C, n?
Negative_regulation (reduced) of Neg (absent) Gene_expression (rises) of Ca2
1) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0 Pain Relevance 0.29
In the following sections, we will present Ca2+ transients either as relative percentage change of the ratio YFP/CFP (?
Negative_regulation (present) of Gene_expression (transients) of Ca2
2) Confidence 0.28 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0.07 Pain Relevance 0.24
associated with a slight although significant decrease in intracellular Ca2+ rise (?
Negative_regulation (decrease) of Gene_expression (rise) of Ca2
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.17 Pain Relevance 0
Nevertheless, additional mechanisms could also contribute to an abnormal synaptic plasticity in transgenic CA1 hippocampal neurons, e.g. the reduced expression of Na+/Ca2+ exchanger-3 in TgDREAM hippocampus that results in elevated intracellular levels of free Ca2+ [43].
Negative_regulation (reduced) of Gene_expression (expression) of Ca2 in hippocampus associated with targeted disruption and hippocampus
4) Confidence 0.20 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.96 Pain Relevance 0.78
Inactivation of the Ca2+ current produced by a long depolarization was slower and incomplete in ?
Negative_regulation (depolarization) of Gene_expression (produced) of Ca2
5) Confidence 0.19 Published 2001 Journal BMC Physiol Section Abstract Doc Link PMC37314 Disease Relevance 0.09 Pain Relevance 0.04
However, for comparative purposes and to be consistent with previous measurements in Ca2+ channels lacking ?
Negative_regulation (lacking) of Gene_expression (channels) of Ca2
6) Confidence 0.19 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.04
Inactivation of the Ca2+ current produced by a long depolarization was slower and incomplete in ?
Negative_regulation (Inactivation) of Gene_expression (produced) of Ca2
7) Confidence 0.19 Published 2001 Journal BMC Physiol Section Abstract Doc Link PMC37314 Disease Relevance 0.09 Pain Relevance 0.04
Most cells showing a Ca2+ response to A?
Negative_regulation (showing) of Gene_expression (response) of Ca2
8) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0 Pain Relevance 0.07
To learn whether inhibition of mitochondrial Ca2+ uptake by NSAIDs prevents cell death induced by A?
Spec (whether) Negative_regulation (inhibition) of Gene_expression (uptake) of Ca2 associated with cinod and death
9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.40 Pain Relevance 0.51
NSAIDs depolarize mitochondria and inhibit mitochondrial Ca2+ uptake
Negative_regulation (inhibit) of Gene_expression (uptake) of Ca2 associated with cinod
10) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.26 Pain Relevance 0.21
The above findings indicate that mitochondrial Ca2+ overload contributes to the neurotoxicity induced by A?
Negative_regulation (mitochondrial) of Gene_expression (overload) of Ca2 associated with drug induced neurotoxicity
11) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 1.30 Pain Relevance 0.41
Accordingly, any strategy intended to prevent specifically mitochondrial Ca2+ uptake could potentially protect neurons against A?
Negative_regulation (prevent) of Gene_expression (uptake) of Ca2 in neurons
12) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 1.23 Pain Relevance 0.52
The above results open the question on whether drugs preventing mitochondrial Ca2+ overload may or may not protect against A?
Negative_regulation (preventing) of Gene_expression (overload) of Ca2
13) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.26 Pain Relevance 0.21
This effect is not due to inhibition of Ca2+ entry through the plasma membrane since 100 nM FCCP does not prevent at all the increase in [Ca2+]cyt induced by A?
Negative_regulation (inhibition) of Gene_expression (entry) of Ca2 in plasma
14) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.20 Pain Relevance 0
Once that conditions are established for specific inhibition of mitochondrial Ca2+ uptake, we addressed the contribution of mitochondrial Ca2+ overload to the cell death induced by A?
Negative_regulation (inhibition) of Gene_expression (uptake) of Ca2 associated with death
15) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.36 Pain Relevance 0
In Ca2+ imaging, the PLC inhibitor U73122 (5 µM), but not the negative control U73343 (5 µM), strongly suppressed the Ca2+ responses induced by denatonium and lilial (t-test, p?
Negative_regulation (suppressed) of Gene_expression (responses) of Ca2 associated with imagery
16) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.09
In Ca2+ imaging, the PLC inhibitor U73122 (5 µM), but not the negative control U73343 (5 µM), strongly suppressed the Ca2+ responses induced by denatonium and lilial (t-test, p?
Negative_regulation (suppressed) of Gene_expression (imaging) of Ca2 associated with imagery
17) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.09
U-73122, an inhibitor of phospholipase C (21), consistently reduced the carbachol responses without affecting basal Ca2+.
Negative_regulation (reduced) of Gene_expression (affecting) of Ca2
18) Confidence 0.18 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.03
M), a blocker of other Ca2+ channels, including T-type (Fig. 4A), reduced transient amplitude from 2.32 ± 0.4 to 1.26 ± 0.26, P = 0.017, n = 7 and a higher concentration (100 ?
Negative_regulation (blocker) of Gene_expression (channels) of Ca2
19) Confidence 0.18 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0.03
HC-056456 blocks evoked Ca2+and Na+ entry
Negative_regulation (blocks) of Gene_expression (entry) of Ca2
20) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

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