INT170528

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 17.98
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cell 18
blood 4
macrophages 2
GALT 2
precursor cells 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 54 99.72 Very High Very High Very High
cocaine 8 99.38 Very High Very High Very High
cytokine 212 98.48 Very High Very High Very High
spinal inflammation 62 97.44 Very High Very High Very High
withdrawal 37 96.40 Very High Very High Very High
opiate 7 95.96 Very High Very High Very High
Inflammation 208 89.52 High High
headache 14 89.16 High High
Central nervous system 178 87.32 High High
Oxycodone 3 82.80 Quite High
Disease Link Frequency Relevance Heat
Confusion 4 99.82 Very High Very High Very High
Amebic Liver Abscess 62 99.78 Very High Very High Very High
Bacterial Infection 8 99.70 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 811 99.52 Very High Very High Very High
Sarcoidosis 85 99.44 Very High Very High Very High
Mycobacterial Infection 27 99.24 Very High Very High Very High
Pneumocystis Carinii Infection 2 99.08 Very High Very High Very High
Leukocytosis 36 99.06 Very High Very High Very High
Infection 433 98.72 Very High Very High Very High
Rheumatoid Arthritis 59 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Development of CD4+CD25high regulatory T cells
Negative_regulation (Development) of Gene_expression (regulatory T cells) of CD4 in regulatory T cells
1) Confidence 0.41 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.06 Pain Relevance 0.04
In HIV-infected ALA patients, CD4 counts varied greatly from 14 to 798/?
Negative_regulation (varied) of Gene_expression (counts) of CD4 associated with amebic liver abscess and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.39 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2374788 Disease Relevance 2.68 Pain Relevance 0.17
In the leflunomide group, there were significant decreases in frequency of both CD4 (Figure 4A) and CD8 (Figure 4B) T cells expressing CCR5 at Day 15 (CD4: ?
Negative_regulation (were) of Gene_expression (frequency) of CD4 in T cells associated with leflunomide
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 0.09 Pain Relevance 0.16
Besides, the study also has shown the association between LPS and chronic in vivo stimulation of monocytes, an association between raised plasma LPS; and an association between reduction in plasma LPS and CD4+ T-cell reconstitution with HAART [21].
Negative_regulation (reduction) of Gene_expression (reconstitution) of CD4 in monocytes
4) Confidence 0.35 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.99 Pain Relevance 0.23
Absence of CD4+ T-cell depletion in the GALT of Mamu-A*01 macaques
Negative_regulation (Absence) of Gene_expression (depletion) of CD4 in GALT
5) Confidence 0.31 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.22 Pain Relevance 0
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Negative_regulation (sorted) of Gene_expression (populations) of CD4
6) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Negative_regulation (reversed) of Gene_expression (production) of CD4 in T cells
7) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24
blocking treatment on the expression of PRRs on CD4+CD28null T cells in vivo, peripheral CD4+CD28null T cells from AS patients were tested before and after successful treatment with TNF-?
Negative_regulation (blocking) of Gene_expression (expression) of CD4 in T cells associated with spinal inflammation
8) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.26 Pain Relevance 0.18
The predominance of T CD4+ lymphocytes in the muscular biopsy of our patient is not in favour of myositis, however the rest histological, laboratory and clinical features appears to be highly supportive of the diagnosis [2]
Negative_regulation (predominance) of Gene_expression (lymphocytes) of CD4 in lymphocytes associated with myositis
9) Confidence 0.29 Published 2008 Journal Cases J Section Body Doc Link PMC2584084 Disease Relevance 1.18 Pain Relevance 0.08
In the high-dose IM group 100% of vaccine recipients exhibited CD4+ T cells producing IFN?
Negative_regulation (exhibited) of Gene_expression (producing) of CD4 in T cells
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981570 Disease Relevance 0 Pain Relevance 0.08
As a group, the CSF neopterin in the OIs differed from: the HIV negatives (P < 0.001); both treatment groups (P < 0.001); NAs with blood CD4 counts >350 cells/?
Negative_regulation (blood) of Gene_expression (counts) of CD4 in blood associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.26 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 1.03 Pain Relevance 0.11
His CSF neopterin rose steeply during the second year of follow-up at a time when was judged neurologically stable until he presented with increasing confusion and was diagnosed with ADC Stage 1 and a blood CD4+ T cell count of 267 cells per ?
Negative_regulation (diagnosed) of Gene_expression (count) of CD4 in T cell associated with confusion
12) Confidence 0.26 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.76 Pain Relevance 0.10
His CSF neopterin rose steeply during the second year of follow-up at a time when was judged neurologically stable until he presented with increasing confusion and was diagnosed with ADC Stage 1 and a blood CD4+ T cell count of 267 cells per ?
Negative_regulation (blood) of Gene_expression (count) of CD4 in T cell associated with confusion
13) Confidence 0.26 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.75 Pain Relevance 0.10
Furthermore, we found a negative correlation between BALF CD4+ T cell IL-17A expression and BALF CD4/CD8 ratio in sarcoidosis, suggesting that the alveolitis seen in patients is associated with an influx of CD4 T cells with on average merely little production of IL-17.
Negative_regulation (correlation) of Gene_expression (expression) of CD4 in T cell associated with sarcoidosis
14) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.04 Pain Relevance 0.03
Furthermore, we found a negative correlation between BALF CD4+ T cell IL-17A expression and BALF CD4/CD8 ratio in sarcoidosis, suggesting that the alveolitis seen in patients is associated with an influx of CD4 T cells with on average merely little production of IL-17.
Negative_regulation (correlation) of Gene_expression (expression) of CD4 in T cell associated with sarcoidosis
15) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 1.03 Pain Relevance 0.03
His CD4 count was 41 cells/?
Negative_regulation (His) of Gene_expression (count) of CD4
16) Confidence 0.23 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC2253556 Disease Relevance 0.82 Pain Relevance 0
First, pleocytosis related only to HIV is uncommon in those with blood CD4 counts below 50 cells/?
Negative_regulation (blood) of Gene_expression (counts) of CD4 in blood associated with acquired immune deficiency syndrome or hiv infection and leukocytosis
17) Confidence 0.20 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.95 Pain Relevance 0.35
They also suppressed the growth of CD4+ CD25?
Negative_regulation (suppressed) of Gene_expression (growth) of CD4
18) Confidence 0.20 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.03 Pain Relevance 0.06
Cocaine is a known immunotoxic agent, decreasing CD4 production threefold and increasing HIV reproduction up to 20-fold [6].
Negative_regulation (decreasing) of Gene_expression (production) of CD4 associated with acquired immune deficiency syndrome or hiv infection and cocaine
19) Confidence 0.17 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.39 Pain Relevance 1.04
In vitro, high concentrations of theophylline suppress CD4+ expression of both Th1 and Th2, excluding IL-5, cytokines probably via inhibition of phosphodiesterases [33,34].
Negative_regulation (suppress) of Gene_expression (expression) of CD4 associated with cytokine
20) Confidence 0.15 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.26

General Comments

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