INT170546

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 14.33
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
hearts 2
finger 1
extracellular matrix 1
neutrophil 1
Renbp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 217 99.28 Very High Very High Very High
cytokine 99 88.36 High High
anesthesia 82 75.60 Quite High
imagery 51 51.16 Quite High
Transcranial magnetic stimulation 2 48.00 Quite Low
Kinase C 36 31.76 Quite Low
chemokine 19 12.48 Low Low
diabetic neuropathy 7 5.12 Low Low
ketamine 34 5.00 Very Low Very Low Very Low
Central nervous system 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 62 99.92 Very High Very High Very High
Ocular Hypertension 676 99.90 Very High Very High Very High
Diabetes Mellitus 501 99.84 Very High Very High Very High
Vasculitis 2 99.64 Very High Very High Very High
Sprains And Strains 349 99.28 Very High Very High Very High
Atherosclerosis 339 98.56 Very High Very High Very High
Atherosclerotic Plaque 140 98.48 Very High Very High Very High
Adhesions 55 98.48 Very High Very High Very High
Shock 24 97.20 Very High Very High Very High
Thrombosis 4 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note that this difference in RT is not due to a difference in the movement speed of the hands since SRT for the left and right hand were equivalent within each age group (young: left?
Gene_expression (group) of age
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0.13 Pain Relevance 0.03
For example, Mitrushina et al. [42] found that, whereas the left-right difference in performance did not vary with the age of the participants in a finger tapping test, the superiority of the dominant hand increased with age in the Pin test, a highly demanding task in terms of visuomotor coordination, attention, and precision of movement.
Neg (not) Gene_expression (vary) of age in finger
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2726952 Disease Relevance 0 Pain Relevance 0
Therefore, to control for potential IOP changes due to measurement time and not age, approximately 3 month old B6 mice were assessed at the same time as each age group.
Gene_expression (group) of age associated with ocular hypertension
3) Confidence 0.12 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.64 Pain Relevance 0.08
Average IOP for age matched mice of the same strain assessed at different times typically differed by no more than 1.5 mmHg, and the differences were usually smaller.
Gene_expression (matched) of age associated with sprains and strains and ocular hypertension
4) Confidence 0.12 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.05 Pain Relevance 0
Although the decrease was of a similar level to the variation observed in 3 month old mice (see Figure 3), the IOPs of control young mice (see Methods) analyzed at the same times as the various B6 age groups did not decrease.
Gene_expression (groups) of age
5) Confidence 0.12 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.02 Pain Relevance 0
For example, control mice analyzed at the same time as the 3 month, 12 month and 18 month B6 age groups had IOPs of 13.0 ± 0.2 mmHg (n = 14), 13.3 ± 0.2 mmHg (n = 14), 13.7 ± 0.4 mmHg (n = 12), respectively.
Gene_expression (groups) of age
6) Confidence 0.12 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.08 Pain Relevance 0
Furthermore, AGE products promote vascular inflammation and induce ROS accumulation, and both of these processes contribute to endothelial dysfunction via inhibition of NO production.
Gene_expression (products) of AGE associated with inflammation and vasculitis
7) Confidence 0.06 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.31 Pain Relevance 0.21
The accumulation of AGE products in diabetes impairs EC function in animal models.
Gene_expression (products) of AGE associated with diabetes mellitus
8) Confidence 0.06 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.19 Pain Relevance 0.21
After 14 days of diabetes, we examined levels of specific AGE species, CML, CEL, furosine (glycated lysine), and pentosidine in BALB/c mouse hearts (Table 1).
Gene_expression (species) of AGE in hearts associated with myeloid leukemia and diabetes mellitus
9) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.26 Pain Relevance 0
Consistent with increased AGE ligand levels in the diabetic heart, a significant increase in RAGE antigen by Western blotting was observed in diabetic compared with nondiabetic hearts (P < 0.05; Fig. 4A).
Gene_expression (levels) of AGE in hearts associated with diabetes mellitus
10) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 1.28 Pain Relevance 0
Collagen will normally accumulate some degree of glycation in vivo, but collagen with synthetic AGE-modification will enhance neutrophil adhesion and spreading [173].
Gene_expression (synthetic) of AGE in neutrophil associated with adhesions
11) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.60 Pain Relevance 0
have confirmed the expression of AGE, as well as AGE receptors within
Gene_expression (expression) of AGE
12) Confidence 0.04 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.72 Pain Relevance 0.04
have confirmed the expression of AGE, as well as AGE receptors within
Gene_expression (expression) of AGE
13) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.77 Pain Relevance 0.04
AGE products stimulate the upregulation of
Gene_expression (products) of AGE
14) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.53 Pain Relevance 0.04
end (AGE) products
Gene_expression (products) of AGE
15) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.60 Pain Relevance 0.04
2GP1), lipoprotein a (LP(a)), heat shock proteins (HSPs), and protein components of the extracellular matrix such as collagen and fibrinogen in the form of advanced glycation-end (AGE) products.
Gene_expression (products) of AGE in extracellular matrix associated with shock
16) Confidence 0.03 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2423423 Disease Relevance 1.14 Pain Relevance 0.03

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