INT170547

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 44
Disease Relevance 64.48
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Narf) biological_process (Narf)
Anatomy Link Frequency
eye 5
outflow 3
blood 1
photoreceptors 1
retinal ganglion cells 1
Narf (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 224 99.60 Very High Very High Very High
anesthesia 592 98.66 Very High Very High Very High
alcohol 28 64.88 Quite High
depression 56 55.80 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 5644 100.00 Very High Very High Very High
Sprains And Strains 2468 100.00 Very High Very High Very High
Diabetes Mellitus 560 99.98 Very High Very High Very High
Glaucoma 1340 99.80 Very High Very High Very High
Obesity 476 99.80 Very High Very High Very High
Hydrophthalmos 80 98.72 Very High Very High Very High
Congenital Anomalies 28 98.52 Very High Very High Very High
Optic Disorders 32 98.00 Very High Very High Very High
Syndrome 16 96.84 Very High Very High Very High
Hypopigmentation 112 96.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IOP is increased during the dark period of the day
Positive_regulation (increased) of IOP associated with ocular hypertension
1) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.75 Pain Relevance 0
The molecular mechanisms underlying the diurnal rhythm are not defined but increased aqueous humor production or flow occurs during the period of increased IOP in both rabbits and humans [63-65].
Positive_regulation (increased) of IOP associated with ocular hypertension
2) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.50 Pain Relevance 0
Ketamine usually appears to increase IOP [31-33], but there are reports of ketamine having no effect on IOP or even reducing IOP [31,34].
Positive_regulation (increase) of IOP associated with ketamine and ocular hypertension
3) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.33 Pain Relevance 0.13
Here, we show increased IOP in mice lacking tyrosinase activity compared to otherwise genetically identical pigmented B6 mice.
Positive_regulation (increased) of IOP associated with ocular hypertension
4) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.98 Pain Relevance 0
The IOP increase in the dark is not dependent on functional rod and cone photoreceptors since these cells degenerate in SWR/J mice due to homozygosity for the Pde6brd1 mutation.
Positive_regulation (increase) of IOP in photoreceptors associated with ocular hypertension
5) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.43 Pain Relevance 0
Obesity or higher body mass index have been implicated by some but not other studies as risk factors for increased IOP and glaucoma [51,55-57].
Positive_regulation (increased) of IOP in body associated with obesity, glaucoma and ocular hypertension
6) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.72 Pain Relevance 0
In support of a later effect of anesthesia (since general anesthesia is reported to mask diurnal variation in IOP [21]), we identified increased IOP during the dark compared to the light period of the day in several tested strains (Figure 6).
Positive_regulation (increased) of IOP associated with anesthesia, sprains and strains and ocular hypertension
7) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.73 Pain Relevance 0.42
Tyrosinase deficiency results in increased IOP
Positive_regulation (increased) of IOP associated with ocular hypertension
8) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.03 Pain Relevance 0
The increased IOP in A/J also was reproducible, with the average IOP of mice assessed in the year 2000 being 14.5 ± 0.4 mmHg (n = 16).
Positive_regulation (increased) of IOP associated with ocular hypertension
9) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.72 Pain Relevance 0
While compromise of aqueous humor outflow is the key determinant of elevation in IOP [3], [4], the molecular mechanisms underlying changes in the outflow pathway that lead to elevated IOP remain to be elucidated.
Positive_regulation (elevated) of IOP in outflow associated with ocular hypertension
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.81 Pain Relevance 0
Several aspects of this model of spontaneous glaucoma will require further study and clarification, although we speculated from our histological results and the correlation between elevated IOP and angle status changes that anatomic angle closure is the possible mechanism for elevated IOP in this model.
Spec (possible) Positive_regulation (elevated) of IOP associated with glaucoma and ocular hypertension
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.91 Pain Relevance 0
Each model has advantages and disadvantages, related to factors such as the ease of inducing elevated IOP, the magnitude, duration and variability of elevated IOP, and secondary effects on the eye.
Positive_regulation (inducing) of IOP in eye associated with ocular hypertension
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 1.05 Pain Relevance 0
Each model has advantages and disadvantages, related to factors such as the ease of inducing elevated IOP, the magnitude, duration and variability of elevated IOP, and secondary effects on the eye.
Positive_regulation (elevated) of IOP in eye associated with ocular hypertension
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 1.04 Pain Relevance 0
Each model has advantages and disadvantages, related to factors such as the ease of inducing elevated IOP, the magnitude, duration and variability of elevated IOP, and secondary effects on the eye.
Positive_regulation (elevated) of IOP in eye associated with ocular hypertension
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 1.04 Pain Relevance 0
The mice were analyzed in the same procedure room as was used for IOP measurment.


Positive_regulation (used) of IOP associated with ocular hypertension
15) Confidence 0.05 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.88 Pain Relevance 0.10
Similarly, the effects of various factors including age, gender, blood pressure, obesity and diabetes have been variably associated with elevated IOP.
Positive_regulation (elevated) of IOP in blood associated with diabetes mellitus, obesity and ocular hypertension
16) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.60 Pain Relevance 0.22
Mutations in two of the assessed candidate genes (Lepr and Tyr) result in increased IOP.
Positive_regulation (increased) of IOP associated with ocular hypertension
17) Confidence 0.04 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.82 Pain Relevance 0
Various factors have been variably associated with risk for increased IOP in humans.
Positive_regulation (increased) of IOP associated with ocular hypertension
18) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.53 Pain Relevance 0
Similarly, diabetes or the combination of diabetes and obesity have been variably associated with elevated IOP and glaucoma [46,52,58-62].
Positive_regulation (elevated) of IOP associated with diabetes mellitus, obesity, glaucoma and ocular hypertension
19) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.84 Pain Relevance 0
Thus, epidemiological associations between increased IOP and obesity or diabetes are supported by this work and appear to be functionally relevant.
Positive_regulation (increased) of IOP associated with diabetes mellitus, obesity and ocular hypertension
20) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.84 Pain Relevance 0

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