INT170548

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Context Info
Confidence 0.06
First Reported 2001
Last Reported 2001
Negated 7
Speculated 0
Reported most in Body
Documents 1
Total Number 24
Disease Relevance 34.17
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Narf) biological_process (Narf)
Anatomy Link Frequency
retina 1
optic nerve 1
Narf (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 480 100.00 Very High Very High Very High
ketamine 192 99.78 Very High Very High Very High
depression 48 83.68 Quite High
alcohol 24 35.20 Quite Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 4056 100.00 Very High Very High Very High
Congenital Anomalies 24 99.98 Very High Very High Very High
Sprains And Strains 2088 99.82 Very High Very High Very High
Aging 72 99.80 Very High Very High Very High
Disease 48 99.80 Very High Very High Very High
Glaucoma 408 99.32 Very High Very High Very High
Obesity 408 98.40 Very High Very High Very High
Diabetes Mellitus 480 97.44 Very High Very High Very High
Unconsciousness 24 96.16 Very High Very High Very High
Hypopigmentation 96 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of anesthetic protocol on IOP during a 12 minute measurement window
Neg (No) Regulation (effect) of IOP associated with ocular hypertension
1) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.28 Pain Relevance 0.12
Initial experiments suggested that an almost identical dose (100 mg/kg ketamine and 9 mg/kg xylazine) of anesthesia had no effect on IOP during the experimental period with IOP being measured as soon as possible after the mouse was unconscious, typically minutes. [13].
Neg (no) Regulation (effect) of IOP associated with anesthesia, ketamine, unconsciousness and ocular hypertension
2) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.49 Pain Relevance 0.37
Here, we show that, despite a depressant effect on IOP by 25 minutes, our anesthetic protocol has no detectable effect on IOP during the first 12 minutes after administration.
Regulation (effect) of IOP associated with ocular hypertension
3) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.33 Pain Relevance 0.34
Here, we show that, despite a depressant effect on IOP by 25 minutes, our anesthetic protocol has no detectable effect on IOP during the first 12 minutes after administration.
Neg (no) Regulation (effect) of IOP associated with ocular hypertension
4) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.16 Pain Relevance 0.35
Our experiments show that a genetic deficiency of CAII in mice homozygous for a mutation in the Car2 gene does not alter IOP.
Neg (not) Regulation (alter) of IOP associated with ocular hypertension
5) Confidence 0.06 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.88 Pain Relevance 0
Effect of sex on IOP
Regulation (Effect) of IOP associated with ocular hypertension
6) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.59 Pain Relevance 0
Therefore, to control for potential IOP changes due to measurement time and not age, approximately 3 month old B6 mice were assessed at the same time as each age group.
Regulation (control) of IOP associated with ocular hypertension
7) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.62 Pain Relevance 0.07
Analysis of these mouse strains may increase understanding of the molecular mechanisms controlling diurnal rhythms of IOP and that may be relevant to glaucoma.


Regulation (controlling) of IOP associated with glaucoma, ocular hypertension and sprains and strains
8) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.19 Pain Relevance 0
An anesthetic effect could potentially alter IOP and mask genetically determined differences in IOP.
Regulation (alter) of IOP associated with ocular hypertension
9) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.30 Pain Relevance 0.26
The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP.


Regulation (effects) of IOP associated with ocular hypertension and sprains and strains
10) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.59 Pain Relevance 0
The purpose of this study was to determine the IOPs of genetically distinct mouse strains, assess the effects of factors such as age, sex and time of day on IOP in specific strain backgrounds, and to assess the effects of specific candidate gene mutations on IOP.


Regulation (effects) of IOP associated with ocular hypertension and sprains and strains
11) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.68 Pain Relevance 0
Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) that causes obesity and diabetes results in increased IOP.
Neg (not) Regulation (alter) of IOP associated with diabetes mellitus, obesity and ocular hypertension
12) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 2.11 Pain Relevance 0
These IOP differences are likely due to interstrain genetic differences that create a powerful resource for studying the regulation of IOP.
Regulation (regulation) of IOP associated with ocular hypertension
13) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 2.07 Pain Relevance 0
These studies demonstrate that mice are a practical and powerful experimental system to study the genetics of IOP regulation and disease processes that raise IOP to harmful levels.



Regulation (regulation) of IOP associated with disease and ocular hypertension
14) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.86 Pain Relevance 0
To test if the Y chromosome of strain 129/Ola alters IOP in relation to that of strain B6, we compared the IOPs of pure B6 males and consomic B6 males that had the 129P2/Ola Y chromosome (backcrossed for 11 generations).
Regulation (alters) of IOP associated with ocular hypertension and sprains and strains
15) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.48 Pain Relevance 0.05
Mice have great potential for helping to characterize the molecular mechanisms affecting IOP.


Regulation (affecting) of IOP associated with ocular hypertension
16) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.39 Pain Relevance 0
It is not known if these abnormalities affect mammalian IOP.
Regulation (affect) of IOP associated with congenital anomalies and ocular hypertension
17) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.97 Pain Relevance 0
Thus, to avoid effects of anesthesia on IOP, all measurements should be made within a window of up to 12 minutes after anesthetic administration.
Regulation (effects) of IOP associated with anesthesia and ocular hypertension
18) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.20 Pain Relevance 0.40
Ketamine usually appears to increase IOP [31-33], but there are reports of ketamine having no effect on IOP or even reducing IOP [31,34].
Neg (no) Regulation (effect) of IOP associated with ketamine and ocular hypertension
19) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.37 Pain Relevance 0.14
Gender does not typically affect IOP and aging results in an IOP decrease in some strains.
Neg (not) Regulation (affect) of IOP associated with aging, sprains and strains and ocular hypertension
20) Confidence 0.03 Published 2001 Journal BMC Genet Section Abstract Doc Link PMC48141 Disease Relevance 1.86 Pain Relevance 0

General Comments

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