INT170550

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Context Info
Confidence 0.04
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 14.89
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Narf) biological_process (Narf)
Anatomy Link Frequency
blood 2
optic 1
Narf (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 162 99.66 Very High Very High Very High
ketamine 64 91.44 High High
depression 16 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 1409 100.00 Very High Very High Very High
Optic Disorders 2 100.00 Very High Very High Very High
Glaucoma 190 99.80 Very High Very High Very High
Obesity 136 99.80 Very High Very High Very High
Diabetes Mellitus 160 99.36 Very High Very High Very High
Sprains And Strains 698 99.16 Very High Very High Very High
Targeted Disruption 3 79.60 Quite High
Unconsciousness 8 69.12 Quite High
Disease 18 50.00 Quite Low
Adhesions 1 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some but not all human studies have reported a positive association between IOP and blood pressure [48,52].
IOP Binding (association) of in blood associated with ocular hypertension
1) Confidence 0.04 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.88 Pain Relevance 0
Anesthesia protocol avoids IOP alteration and allows detection of diurnal differences
IOP Binding (alteration) of associated with anesthesia and ocular hypertension
2) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.46 Pain Relevance 0.33
Average IOP for age matched mice of the same strain assessed at different times typically differed by no more than 1.5 mmHg, and the differences were usually smaller.
IOP Binding (Average) of associated with sprains and strains and ocular hypertension
3) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.06 Pain Relevance 0
Blood pressure does not correlate with IOP
IOP Neg (not) Binding (correlate) of in Blood associated with ocular hypertension
4) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.68 Pain Relevance 0.35
Myoc alleles do not associate with the magnitude of IOP
IOP Binding (magnitude) of associated with ocular hypertension
5) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.50 Pain Relevance 0.32
The presence or absence of this allele does not associate with IOP as it is present in strains with a range of IOPs (Figure 8).


IOP Binding (associate) of associated with sprains and strains and ocular hypertension
6) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.46 Pain Relevance 0.11
Thus, epidemiological associations between increased IOP and obesity or diabetes are supported by this work and appear to be functionally relevant.
IOP Binding (associations) of associated with diabetes mellitus, obesity and ocular hypertension
7) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 2.91 Pain Relevance 0
These are important approaches as they may allow the association of genes with IOP and glaucoma whose currently known functions do not suggest that they affect aqueous humor dynamics or do not immediately identify them as likely glaucoma candidates.


IOP Binding (association) of associated with glaucoma and ocular hypertension
8) Confidence 0.03 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.21 Pain Relevance 0.07
The critical importance of elevated intraocular pressure (IOP) in the pathogenesis of glaucomatous optic neuropathy is widely recognized [1], [2].
IOP Binding (recognized) of in optic associated with ocular hypertension and optic disorders
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816215 Disease Relevance 0.73 Pain Relevance 0

General Comments

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